Results 11 to 20 of about 4,285 (67)

Molecular Mechanisms of Age‐Related Taste Dysfunction Deciphered by Spatiotemporal Transcriptomics

Aging Cell, Volume 25, Issue 9, September 2026.
Multi‐omics profiling reveals that aging impairs stem/progenitor cell differentiation and taste bud regeneration in the posterior tongue. Age‐related macrophage polarization remodeling, marked by the accumulation of pro‐inflammatory M1 macrophages, contributes to a Thbs1‐enriched inhibitory niche that limits taste cell growth and differentiation ...
Wandong Zhao, Xudong Cha, Yingqi Xie, Enhao Wang, Wenlu Xing, Zengyi Xu, Langchao Liang, Changhai Xiong, Morong Zhou, Penghui Fu, Zhe Wang, Xin Liu, Yiqun Yu, Huanhai Liu, Hanbo Li, Wenwen Ren   +15 more
wiley   +1 more source

Temporal shifts in antiretroviral therapy regimens and metabolic outcomes in people living with HIV: A systematic review and meta‐analysis

HIV Medicine, Volume 27, Issue 9, Page 1399-1420, September 2026.
Abstract Introduction Antiretroviral therapy (ART) for people living with HIV has led to dramatically reduced mortality and improved life expectancy. This achievement is accompanied by a higher risk for metabolic and other non‐communicable diseases. The role and contribution of various ART regimens to adverse metabolic outcomes are not fully understood.
Melani Ratih Mahanani, Myo Chit, Sophie Mohr, Elisenda Cama i Gibernau, Svetlana Hetjens, Volker Winkler, Hans‐Michael Steffen, Florian Neuhann   +7 more
wiley   +1 more source

Quantifying Daily Vertical Heat Flux in the Loop Current System: A Quasi‐Lagrangian Assessment of Frontal Hotspots

Geophysical Research Letters, Volume 53, Issue 15, 16 August 2026.
Abstract Vertical heat exchange within the upper ocean critically influences regional climate but remains difficult to observe directly. In the Gulf of Mexico, the Loop Current and its associated eddies significantly enhance this exchange. High‐resolution glider observations reveal that this transport is dominated by sub‐daily variability an order of ...
Sakib Mahmud, Xiao Ge, Uchenna Nwankwo, Anthony Knap, Steven F. DiMarco   +4 more
wiley   +1 more source

Tuning Mechanoreceptor Signaling Enhances the Adjuvant Effect of Biomaterial Vaccines

Advanced Functional Materials, Volume 36, Issue 66, 17 August 2026.
Matrix stiffness serves as an independent immunological signal in biomaterial vaccines. Stiffer microporous hydrogel vaccines enhance dendritic cell maturation and migration to draining lymph nodes, promote T follicular helper cell expansion through Yap/Taz signaling, and increase antigen‐specific antibody production.
Lily Shang, Daniel P. Mayer, Prabhat K. Purbey, Yingzi Liu, Kindra Kelly‐Scumpia, Clara Kang, Natalie Tsubamoto, Dhriti Bolangadi, Iqra Arshad, Charisse Ng, Maksim V. Plikus, Dino Di Carlo, Jason S. Weinstein, Philip O. Scumpia   +13 more
wiley   +1 more source

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, Volume 13, Issue 44, 7 August 2026.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils

Advanced Science, Volume 13, Issue 47, 24 August 2026.
We show that immune cells (neutrophils) synthesize, uptake, and store catecholamine neurotransmitters such as dopamine or adrenaline. They also release them in response to specific stimuli (serotonin), which we directly visualize using fluorescent nanosensors. We further demonstrate that catecholamines affect neutrophil functions (NETosis) and platelet
Jennifer Mohr, Anne Schmitz, Meshkat Dinarvand, Franziska Wulfert, Sangeetha Shankar, Bjoern F. Hill, Michael Wojak, Juliana Gretz, Marie Britz, Elsa Neubert, Magdalena Shumanska, Sofia Kaushik, Linda Kartaschew, Ivan Bogeski, James Daniel, Sebastian Jung, Johannes Eble, Guido Wabnitz, Luise Erpenbeck, Sebastian Kruss   +19 more
wiley   +1 more source

Engineering Neuronal Network Connectivity Through Precise and Scalable Electrical Modulation

Advanced Science, Volume 13, Issue 43, 3 August 2026.
This study presents a scalable all‐electrical method for precise neuronal‐circuit reconfiguration based on high‐density microelectrode arrays. By employing biologically inspired plasticity rules, targeted connectivity changes were successfully induced and quantified across diverse neuronal preparations.
Sreedhar S. Kumar, Yannaël Bossard, Rachel Sava, Tobias Gänswein, Lorenca Sadiraj, Jean‐Samuel Dupré, Manuel Schröter, J. Gray Camp, Fernando Cardes, Julian Bartram, Andreas Hierlemann   +10 more
wiley   +1 more source

Disulfiram Exhibits Potent Copper-Dependent Antimicrobial Activity Against <i>Mycoplasma genitalium</i>. [PDF]

Open Forum Infect Dis
Xiao L, Gimblet GR, Lapi SE, Geisler WM, Daubenspeck J, Atkinson TP.   +5 more
europepmc   +1 more source

Coordination electrochemistry taming reversible hypervalent bromine redox for energetic six-electron-transfer lithium-bromine battery. [PDF]

Nat Commun
Feng R, Xu W, Wang H, Wang B, Li J, Chang Z, Huang Z, Chen Z, Li X.   +8 more
europepmc   +1 more source

Noradrenaline Regulation of Tyrosine Hydroxylase Expression in Arcuate Nucleus Neurons in Young and Adult Rats. [PDF]

Int J Mol Sci
Pronina TS, Troshev DV, Ugrumov MV.
europepmc   +1 more source