Results 1 to 10 of about 72,479 (112)

EV-301 long-term outcomes: 24-month findings from the phase III trial of enfortumab vedotin vs chemotherapy in patients with previously treated advanced urothelial carcinoma.

Annals of Oncology, 2023
INTRODUCTION This exploratory analysis evaluated efficacy and safety data for enfortumab vedotin versus chemotherapy over median follow-up of approximately 2 years from EV-301.
J. Rosenberg, T. Powles, G. Sonpavde, Y. Loriot, I. Durán, J.L. Lee, N. Matsubara, C. Vulsteke, D. Castellano, R. Mamtani, C. Wu, M. Matsangou, M. Campbell, D. Petrylak   +13 more
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Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension

Journal of Clinical Investigation, 2022
Development of the vascular disease pulmonary hypertension (PH) involves disparate molecular pathways that span multiple cell types. MicroRNAs (miRNAs) may coordinately regulate PH progression, but the integrative functions of miRNAs in this process have
T. Bertero, Yu Lu, S. Annis, Andrew E Hale, B. Bhat, R. Saggar, R. Saggar, W. Wallace, D. Ross, S. Vargas, B. Graham, Rahul Kumar, S. Black, S. Fratz, J. Fineman, J. West, K. Haley, A. Waxman, B. Chau, K. A. Cottrill, S. Y. Chan   +20 more
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Melanin Synthesis Pathway Interruption: CRISPR/Cas9-mediated Knockout of dopa decarboxylase (DDC) in Harmonia axyridis (Coleoptera: Coccinellidae)

Journal of Insect Science, 2022
CRISPR/Cas9 technology is a very powerful genome editing tool and has been used in many insect species for functional genomics studies through targeted gene mutagenesis.
Meng-meng Wu, Xu Chen, Qingbiao Xu, L. Zang, Su Wang, Ming Li, D. Xiao   +6 more
semanticscholar   +1 more source

Multi-omics profiles refine L-dopa decarboxylase (DDC) as a reliable biomarker for prognosis and immune microenvironment of clear cell renal cell carcinoma

Frontiers in Oncology, 2022
Background Increasing evidence indicates that L-dopa decarboxylase (DDC), which mediates aberrant amino acid metabolism, is significantly associated with tumor progression.
Kun Chang, Jia-Qi Su, Chuanyu Li, Aihetaimujiang Anwaier, Wangrui Liu, Wenhao Xu, Y. Qu, Hailiang Zhang, Dingwei Ye   +8 more
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In Arabidopsis thaliana Cd differentially impacts on hormone genetic pathways in the methylation defective ddc mutant compared to wild type

Scientific Reports, 2021
DNA methylation plays an important role in modulating plant growth plasticity in response to stress, but mechanisms involved in such control need further investigation.
M. Pacenza, A. Muto, A. Chiappetta, L. Mariotti, E. Talarico, P. Picciarelli, E. Picardi, L. Bruno, M. B. Bitonti   +8 more
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Preclinical In Vitro Studies with 3D Spheroids to Evaluate Cu(DDC)2 Containing Liposomes for the Treatment of Neuroblastoma

Pharmaceutics, 2021
Preclinical in vitro studies of drug candidates for anticancer therapy are generally conducted on well-established 2D cell models. Unfortunately, these models are unable to mimic the properties of in vivo tumors.
F. Hartwig, Monika Köll-Weber, R. Süss
semanticscholar   +1 more source

KSI-301: antibody biopolymer conjugate in retinal disorders

Therapeutic Advances in Ophthalmology, 2021
KSI-301 is a new intravitreal anti-vascular endothelial growth factor (VEGF) antibody biopolymer conjugate under investigation for the treatment of age-related macular degeneration (AMD), diabetic macular oedema (DME) and retinal vein occlusion (RVO ...
P. Chandrasekaran, V. Madanagopalan
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A phase 2, randomized, double-blind, placebo-controlled trial of AMG 301, a pituitary adenylate cyclase-activating polypeptide PAC1 receptor monoclonal antibody for migraine prevention

Cephalalgia, 2020
Objective To assess the safety and efficacy of AMG 301, an inhibitor of the pituitary adenylate cyclase-activating polypeptide (PACAP)-1 (PAC1) receptor, for prevention of migraine.
M. Ashina, D. Doležil, J. Bonner, Lifen Zhou, J. Klatt, H. Picard, D. Mikol   +6 more
semanticscholar   +1 more source

Review on the Comparison of the Chemical Reactivity of Cyanex 272, Cyanex 301 and Cyanex 302 for Their Application to Metal Separation from Acid Media

Metals, 2020
Cyanex extractants, such as Cyanex 272, Cyanex 301, and Cyanex 302 have been commercialized and widely used in the extraction and separation of metal ions in hydrometallurgy.
Viet Nhan Hoa Nguyen, Thi Hong Nguyen, Man-Seung Lee   +2 more
semanticscholar   +1 more source

Revised Exon Structure of l-DOPA Decarboxylase (DDC) Reveals Novel Splice Variants Associated with Colorectal Cancer Progression

International Journal of Molecular Sciences, 2020
Colorectal cancer (CRC) is a highly heterogenous malignancy with an increased mortality rate. Aberrant splicing is a typical characteristic of CRC, and several studies support the prognostic value of particular transcripts in this malignancy.
P. Artemaki, Maria Papatsirou, Michaela A. Boti, P. Adamopoulos, S. Christodoulou, D. Vassilacopoulou, A. Scorilas, C. Kontos   +7 more
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