Results 21 to 30 of about 79,876 (114)

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

Analysis of Expression and Functional Activity of Aromatic L-Amino Acid Decarboxylase (DDC) and Serotonin Transporter (SERT) as Potential Sources of Serotonin in Mouse Ovary

International Journal of Molecular Sciences, 2019
The origin of serotonin in the ovary is the key question for understanding mechanisms of serotonergic regulation of reproductive function. We performed a study of the expression and functional activity of the serotonin transporter (SERT) and the enzyme ...
D. A. Nikishin, N. M. Alyoshina, M. Semenova, Y. B. Shmukler   +3 more
semanticscholar   +1 more source

Metformin and insulin exacerbate one‐carbon metabolism deficits in pregnant growth restricted rats and impacts the placenta, fetal liver and pancreas

The Journal of Physiology, Volume 603, Issue 19, Page 5751-5775, October 1, 2025.
Abstract figure legend Uteroplacental insufficiency (growth restricted) or sham (Control) surgery was performed on embryonic day (E)18 in Wistar–Kyoto rats. Female F1 offspring were mated and restricted dams received daily metformin, insulin or vehicle from E13.
Dayna A. Zimmerman, Jessica F. Briffa, Dewei Kong, Sogand Gravina, Dara Daygon, Vinod Kumar, Karen M. Moritz, Lillian Y. Lim, Adrian K. K. Teo, Shiao‐Yng Chan, Mary E. Wlodek, James S. M. Cuffe   +11 more
wiley   +1 more source

Ferroptosis in Cancer and Inflammatory Diseases: Mechanisms and Therapeutic Implications

MedComm, Volume 6, Issue 9, September 2025.
Ferroptosis, a form of cell death driven by iron and lipid peroxidation, serves as a bridge between cancer and inflammatory diseases. Microenvironmental factors such as oxidative stress collectively regulate this process. In cancer, ferroptosis exhibits dual roles: while it eliminates drug‐resistant cells, it may also promote tumor metastasis.
Guangyi Shen, Jiachen Liu, Yinhuai Wang, Zebin Deng, Fei Deng   +4 more
wiley   +1 more source

The Antistaphylococcal Lysin, CF-301, Activates Key Host Factors in Human Blood To Potentiate Methicillin-Resistant Staphylococcus aureus Bacteriolysis

Antimicrobial Agents and Chemotherapy, 2019
Bacteriophage-derived lysins are cell-wall-hydrolytic enzymes that represent a potential new class of antibacterial therapeutics in development to address burgeoning antimicrobial resistance.
C. Indiani, K. Sauvé, Assaf Raz, W. Abdelhady, Y. Xiong, C. Cassino, A. Bayer, R. Schuch   +7 more
semanticscholar   +1 more source

Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure

Cell Proliferation, Volume 58, Issue 9, September 2025.
This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan, Zhou Chen, Yuhua Zhang, Wenjie Sun, Lifei Li, Xia Huang   +5 more
wiley   +1 more source

The pivotal role of mass spectrometry in transition metal‐based photocatalyst research for solar‐driven energy conversion and water purification advancements

Bulletin of the Korean Chemical Society, Volume 46, Issue 4, Page 381-412, April 2025.
This review explores recent advancements in the integration of solar energy conversion and water remediation with mass spectrometry as an analytical technique. We examine Ti‐based photocatalysts for their roles in energy conversion and water purification, utilizing mass spectrometric analysis to evaluate the efficiency of these mechanisms.
Haheun Yoo, Hyojin Hwang, Hyojin Kang, Jeongkwon Kim, Jaebeom Lee   +4 more
wiley   +1 more source

Orally inhaled levodopa (CVT-301) for early morning OFF periods in Parkinson's disease.

Parkinsonism & Related Disorders, 2019
BACKGROUND CVT-301 (Inbrija) is a self-administered orally inhaled levodopa approved for the intermittent treatment of OFF episodes in patients with Parkinson's disease (PD) treated with carbidopa/levodopa.
R. Hauser, S. Isaacson, A. Ellenbogen, B. Safirstein, D. Truong, S. Komjathy, D. Kegler-Ebo, Ping Zhao, Charles Oh   +8 more
semanticscholar   +1 more source

Opinion and report of the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) relating to an analysis of the health risks associated with exposure to caterpillars with stinging hairs and the development of management recommendations

Food Risk Assess Europe, Volume 3, Issue 2, April 2025.
Abstract Several species of Lepidoptera with caterpillars bearing urticating hairs are increasing their range in metropolitan France from year to year, such as the pine processionary (Thaumetopoea pityocampa Denis et Schiffermüller 1775) whose presence was historically limited to the south of France, and which is gradually being observed in the north ...
Nicolas Desneux, Andrea Battisti, Anne‐Sophie Brinquin, Rudy Caparros‐Megido, Gilbert Gault, Carole Kerdelhué, Stéphane Krebs, Myriam Mérad, Catherine Pecquet, Tina Rambonilaza, Thomas Le Bourgeois, Philippe Castagnone, Thierry Candresse, Nicolas Desneux, Sandrine Eveillard, Florence Fontaine, Pascal Gentit, Martin Godefroidd, Lucia Guerin, Bruno Hostachy, Hervé Jactel, Eleni Kazakou, Christophe Le May, Eric Lombaert, David Markowski, Charles Manceau, Arnaud Monty, Maria Navajas, Céline Robin, Aurélien Sallé, Frédéric Suffert, Stéphan Steyer, Pierre‐Yves Teycheney, Eric Verdin, François Verheggen, Gilles Meyer, Xavier Bailly, Catherine Belloc, Stéphane Bertagnoli, Alain Boissy, Séverine Boullier, Henri‐Jean Boulouis, Eric Cardinale, Aurélie Courcoul, Alice De Boyer Des Roches, Barbara Dufour, Veasna Duong, Emmanuelle Gilot‐Fromont, Etienne Giraud, Lionel Grisot, Claire Guinat, Nadia Haddad, Elsa Jourdain, Hervé Juin, Sophie Le Bouquin‐Le Neveu, Caroline Le Maréchal, Sophie Le Poder, Yves Millemann, Pierre Mormède, Carole Peroz, Claire Ponsart, Céline Richomme, Claude Saegerman, Jean‐François Valarcher, Isabelle Vallée, Agnès Waret‐Szkuta, Natacha Woronoff‐Rehn, Georges De Sousa, Olivier Adam, Alain Aymard, Jean‐Christophe Cahuzac, Pierre Greve, Philippe Hartemann, Claire Hellio, Dominique Pessel, Vincent Richard, Christophe Soumet, Laura Maxim, Louis‐Georges Soler, Bénédicte Apouey, Luc Baumstark, Céline Bonnet, Thierry Brunelle, France Caillavet, Alain Carpentier, Thomas Coutrot, Cécile Detang‐Dessendre, Serge Garcia, Julien Gauthey, Emmanuelle Lavaine, Christine Le Clainche, Marc Leandri, Youenn Loheac, Sélim Louafi, Eric Plottu, Elodie Rouviere, Maïder Saint‐Jean, Denis Salles, Léa Tardieu, Jean‐Christophe Vergnaud, Jens Abildtrup, Catherine Collignon, Karine Fiore, Emeline Hily, Sandra Sinno‐Tellier, Emmanuel Gachet   +105 more
wiley   +1 more source

Gene therapy for genetic diseases: challenges and future directions

MedComm, Volume 6, Issue 2, February 2025.
The graphical abstract provides an overview of gene therapy approaches, detailing the components of the therapy and the various delivery routes. Both in vivo and ex vivo strategies facilitate the implementation of gene replacement, gene suppression, gene supplementation, and gene editing.
Beibei Qie, Jianghua Tuo, Feilong Chen, Haili Ding, Lei Lyu   +4 more
wiley   +1 more source