Results 31 to 40 of about 72,479 (112)

Protective effect of green perilla-derived chalcone derivative DDC on amyloid β protein-induced neurotoxicity in primary cortical neurons.

open access: yesBiological and Pharmaceutical Bulletin, 2019
Amyloid β protein (Aβ) causes neurotoxicity and cognitive impairment in Alzheimer's disease (AD). Oxidative stress is closely related to the pathogenesis of AD.
M. Iwasaki   +5 more
semanticscholar   +1 more source

Pivotal roles of Kupffer cells in the progression and regression of DDC-induced chronic cholangiopathy

open access: yesScientific Reports, 2018
Kupffer cells (KCs) are key players in maintaining tissue homeostasis and are involved in various liver diseases. However, the roles of KCs in the pathogenesis of cholangiopathy are largely unknown.
Leila Jemail   +6 more
semanticscholar   +1 more source

Assessing intrinsic capacity for person‐centred HIV care: a cross‐sectional study in ageing populations in Malaysia and Hong Kong

open access: yesJournal of the International AIDS Society, Volume 28, Issue 1, January 2025.
Abstract Introduction WHO's Integrated Care for Older People (ICOPE) proposes we measure the functional construct of intrinsic capacity (IC) to monitor and identify individuals with age‐associated vulnerabilities. Assessments of IC may be useful to address the evolving, non‐HV care needs of ageing people with HIV (PWH).
Reena Rajasuriar   +16 more
wiley   +1 more source

A randomized trial of inhaled levodopa (CVT‐301) for motor fluctuations in Parkinson's disease

open access: yesMovement Disorders, 2016
Although levodopa is the most effective oral PD therapy, many patients experience motor fluctuations, including sudden loss of dose effect and delayed benefit. CVT‐301 is a levodopa inhalation powder with the potential for rapid onset of action.
P. LeWitt   +10 more
semanticscholar   +1 more source

Integrase inhibitor drugs during pregnancy and congenital anomalies: A case/non‐case study from the global pharmacovigilance database VigiBase®

open access: yesPharmacology Research &Perspectives, Volume 12, Issue 4, August 2024.
Abstract In 2018, a significant neural tube defects (NTD) signal was reported after pre‐conceptional exposure to dolutegravir, but was not confirmed in further analysis. Since 2019, dolutegravir‐based regimen, an integrase inhibitor (INI), is recommended by WHO as the most‐effective first‐line therapy in all patients living with HIV.
Laura Saint‐Lary   +3 more
wiley   +1 more source

Advancements of non‐invasive imaging technologies for the diagnosis and staging of liver fibrosis: Present and future

open access: yesVIEW, Volume 5, Issue 4, August 2024.
The authors provide an in‐depth exploration of recent advancements in ultrasound imaging, computed tomography imaging, magnetic resonance imaging, nuclear medicine imaging, radiomics, and artificial intelligence within the field of liver fibrosis research.
Wenpeng Huang, Yushuo Peng, Lei Kang
wiley   +1 more source

Luteolin inhibited proliferation and induced apoptosis of prostate cancer cells through miR-301

open access: yesOncoTargets and Therapy, 2016
Luteolin is a falvonoid compound derived from Lonicera japonica Thunb. Numerous reports have demonstrated that luteolin has anticancer effects on many kinds of tumors.
Kun Han   +9 more
semanticscholar   +1 more source

The Sins of the Fathers: Targeted Sanctions against Family Members of Primary Targets

open access: yesThe Modern Law Review, Volume 87, Issue 4, Page 926-966, July 2024.
Targeted sanctions, such as asset freezes and travel bans, are an increasingly popular response to a wide array of wrongdoing. This article considers an especially problematic aspect of contemporary sanctions law and practice that has received little attention so far, namely the imposition of sanctions on the family members of the primary target.
Anton Moiseienko
wiley   +1 more source

Pulmonary Safety and Tolerability of Inhaled Levodopa (CVT-301) Administered to Patients with Parkinson's Disease

open access: yesJournal of Aerosol Medicine, 2017
Background: CVT-301, an inhaled levodopa (LD) formulation, is under development for relief of OFF periods in Parkinson's disease (PD). Previously, we reported that CVT-301 improved OFF symptoms relative to placebo.
P. LeWitt   +5 more
semanticscholar   +1 more source

A pairwise distance distribution correction (DDC) algorithm to eliminate blinking-caused artifacts in SMLM

open access: yesNature Methods, 2021
C. Bohrer   +12 more
semanticscholar   +1 more source

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