Results 11 to 20 of about 889 (66)

Chronic Low-Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification. [PDF]

J Appl Toxicol
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Liu F, Liu B, Wang K, Wang X, Sun Z, Pan X, Zhao Z.   +6 more
europepmc   +2 more sources

The CRISPR-Cas9 knockout DDC SH-SY5Y in vitro model for AADC deficiency provides insight into the pathogenicity of R347Q and L353P variants: a cross-sectional structural and functional analysis. [PDF]

FEBS J
Here, we generated a DDC‐KO cellular model for studying aromatic amino acid decarboxylase (AADC) deficiency. This model was created using CRISPR‐Cas9 in the SH‐SY5Y neuroblastoma cell line and was validated through the absence of the dopamine product and an altered l‐dopa metabolite profile.
Carmona-Carmona CA, Bisello G, Franchini R, Lunardi G, Galavotti R, Perduca M, Ribeiro RP, Belviso BD, Giorgetti A, Caliandro R, Lievens PM, Bertoldi M.   +11 more
europepmc   +2 more sources

Cannabinoid CB₂ receptor-mediated analgesia: mechanism-based insights and therapeutic potential. [PDF]

Br J Pharmacol
Agonists of the cannabinoid 2 (CB2) receptor have shown promise for the treatment of pain in a variety of animal models. However, despite current preclinical evidence supporting the use of CB2 agonists for pain, successful translation of findings from preclinical models to human patients is lacking.
Guenther KG, Hohmann AG.
europepmc   +2 more sources

Single‐Cell RNA Sequencing Informs Precision Targeting of Monogenic Lupus Associated With IKZF1 Haploinsufficiency

Arthritis &Rheumatology, Volume 78, Issue 6, Page 1231-1244, June 2026.
Objective This study aimed to investigate the mechanisms of immune dysregulation in a pediatric patient with monogenic lupus driven by IKZF1 haploinsufficiency. Methods Peripheral immune cells from a patient with IKZF1 haploinsufficiency, patients with lupus with no currently known genetic mutations, and healthy controls were analyzed using single‐cell
Qi Zheng, Yejun Tan, Zhaoling Wang, Yanjie Qian, Qian Ma, Danping Shen, Meiping Lu   +6 more
wiley   +1 more source

Deep Learning Reconstruction for 129Xe Diffusion‐Weighted MRI Enables Use of Natural Abundant Xenon and Improved Image Acceleration

Magnetic Resonance in Medicine, Volume 95, Issue 4, Page 2214-2222, April 2026.
ABSTRACT Purpose (i) To assess whether 129Xe apparent diffusion coefficient (ADC) and diffusive length scale (LmD) metrics are quantitatively preserved with deep learning (DL) accelerated acquisition and reconstruction and (ii) to evaluate the feasibility of 129Xe diffusion weighted imaging with natural‐abundance xenon at increased acceleration factors.
Rajagopalan Sundaresan, Guilhem J. Collier, Neil J. Stewart, Sudhanya Chatterjee, Ramesh Venkatesan, Jan Wolber, Jim M. Wild   +6 more
wiley   +1 more source

NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease

Advanced Science, Volume 13, Issue 14, 9 March 2026.
NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim, Seung Eun Lee, Wonwoong Lee, Yoon Ha, Sungho Park, Jieun Kim, Won‐Young Cho, Woong Sun, Jong‐Seo Kim, Junsang Yoo   +18 more
wiley   +1 more source

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

Allelopathy as a Strategy for Biological Invasion: Calotropis procera and Its Impact on Plant Succession

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
Stages of the study on the allelopathic potential of Calotropis procera (Aiton) W. T. Aiton. The image shows the collection of plant material, the decomposition of organic matter, the identification of bioactive compounds, and the effects on the germination of Handroanthus impetiginosus (Mart. ex DC.) Mattos.
Bruno Melo de Alcântara, Paulo Henrique Calixto Santana, Felipe Rufino dos Santos, José Weverton Almeida‐Bezerra, José Galberto Martins da Costa, Delmira da Costa Silva, Cláudia Maria Furlan, Maria Arlene Pessoa da Silva   +7 more
wiley   +1 more source

Efficiency‐Core Volume Optimal Design of Variable Inductor Integrated LLC Resonant Converter

IET Power Electronics, Volume 19, Issue 1, January/December 2026.
This paper proposes a two‐step optimisation methodology for variable inductor integrated LLC (VI‐LLC) resonant converters to maximise efficiency and minimise magnetic core volume. The approach first uses time‐domain modelling and operational constraints to identify feasible design candidates, which are subsequently evaluated for power loss and optimal ...
Sinan Tang, Guiping Du, Mingtao Wu
wiley   +1 more source

Bone metastases from neuroendocrine neoplasms: Results of an Italian nationwide survey of natural history and management

Journal of Neuroendocrinology, Volume 38, Issue 1, January 2026.
Abstract Bone metastases (BMs) were reported in <15% of cases of neuroendocrine neoplasms (NENs). Their clinical behavior is various and clinical management is still undefined. This study aimed to describe the clinical practical management and survival outcome of neuroendocrine neoplasm patients with BMs.
Nicola Fazio, Patrick Maisonneuve, Anna Maria Frezza, Nicoletta Ranallo, Toni Ibrahim, Anna La Salvia, Maria Pia Brizzi, Chiara De Divitiis, Salvatore Tafuto, Sara Pusceddu, Riccardo Marconcini, Mauro Cives, Cristina Ferrari, Davide Campana, Delia De Lisi, Daniele Santini, Antongiulio Faggiano, Roberta Modica, Sara Massironi, Antonio Bianchi, Francesco Panzuto, Lorenzo Antonuzzo, Elisa Pellegrini, Vito Amoroso, Ivana Puliafito, Elettra Merola, Nicola Silvestris, Chiara Maria Grana, Francesca Spada   +28 more
wiley   +1 more source