Results 1 to 10 of about 102,839 (113)

A pairwise distance distribution correction (DDC) algorithm to eliminate blinking-caused artifacts in SMLM. [PDF]

Nat Methods, 2021
Bohrer CH, Yang X, Thakur S, Weng X, Tenner B, McQuillen R, Ross B, Wooten M, Chen X, Zhang J, Roberts E, Lakadamyali M, Xiao J.   +12 more
europepmc   +2 more sources

Melanin Synthesis Pathway Interruption: CRISPR/Cas9-mediated Knockout of dopa decarboxylase (DDC) in Harmonia axyridis (Coleoptera: Coccinellidae)

Journal of Insect Science, 2022
CRISPR/Cas9 technology is a very powerful genome editing tool and has been used in many insect species for functional genomics studies through targeted gene mutagenesis.
Meng-meng Wu, Xu Chen, Qingbiao Xu, L. Zang, Su Wang, Ming Li, D. Xiao   +6 more
semanticscholar   +1 more source

Multi-omics profiles refine L-dopa decarboxylase (DDC) as a reliable biomarker for prognosis and immune microenvironment of clear cell renal cell carcinoma

Frontiers in Oncology, 2022
Background Increasing evidence indicates that L-dopa decarboxylase (DDC), which mediates aberrant amino acid metabolism, is significantly associated with tumor progression.
Kun Chang, Jia-Qi Su, Chuanyu Li, Aihetaimujiang Anwaier, Wangrui Liu, Wenhao Xu, Y. Qu, Hailiang Zhang, Dingwei Ye   +8 more
semanticscholar   +1 more source

In Arabidopsis thaliana Cd differentially impacts on hormone genetic pathways in the methylation defective ddc mutant compared to wild type

Scientific Reports, 2021
DNA methylation plays an important role in modulating plant growth plasticity in response to stress, but mechanisms involved in such control need further investigation.
M. Pacenza, A. Muto, A. Chiappetta, L. Mariotti, E. Talarico, P. Picciarelli, E. Picardi, L. Bruno, M. B. Bitonti   +8 more
semanticscholar   +1 more source

Preclinical In Vitro Studies with 3D Spheroids to Evaluate Cu(DDC)2 Containing Liposomes for the Treatment of Neuroblastoma

Pharmaceutics, 2021
Preclinical in vitro studies of drug candidates for anticancer therapy are generally conducted on well-established 2D cell models. Unfortunately, these models are unable to mimic the properties of in vivo tumors.
F. Hartwig, Monika Köll-Weber, R. Süss
semanticscholar   +1 more source

MicroRNA miR-330-3p suppresses the progression of ovarian cancer by targeting RIPK4

Bioengineered, 2021
Previous studies reported that miR-330-3p was involved in the progression of several cancers, but the potential roles of miR-330-3p in ovarian cancer (OC) were unclear. In the current study, we aimed to explore the expression pattern and functions of miR-
Li Cai, Lu Ye, Xiaoqing Hu, Wen-feng He, Debao Zhuang, Qi Guo, Kuanyong Shu, Youkun Jie   +7 more
semanticscholar   +1 more source

The Tumor-Suppressive Human Circular RNA CircITCH Sponges miR-330-5p to Ameliorate Doxorubicin-Induced Cardiotoxicity Through Upregulating SIRT6, Survivin, and SERCA2a

Circulation Research, 2020
Supplemental Digital Content is available in the text. Rationale: Doxorubicin is one of the most potent antitumor agents available; however, its clinical use is restricted because it poses a risk of severe cardiotoxicity.
Dong Han, Yongjun Wang, Yabin Wang, Xinchun Dai, Tingwen Zhou, Jiangwei Chen, B. Tao, Jibin Zhang, F. Cao   +8 more
semanticscholar   +1 more source

CircHIPK3 Promotes Gemcitabine (GEM) Resistance in Pancreatic Cancer Cells by Sponging miR-330-5p and Targets RASSF1

Cancer Management and Research, 2020
Background Pancreatic cancer is one of the most common malignant diseases in the world. Gemcitabine chemotherapy remains the most important clinical treatment.
Yunfei Liu, L. Xia, Luo Dong, Jiale Wang, Qiangsheng Xiao, Xiao Yu, Hongwei Zhu   +6 more
semanticscholar   +1 more source

CircGCN1L1 promotes synoviocyte proliferation and chondrocyte apoptosis by targeting miR-330-3p and TNF-α in TMJ osteoarthritis

Cell Death and Disease, 2020
Altered expression of circular RNAs (circRNAs) has been identified in various human diseases. In this study, we investigated whether circRNAs function as competing endogenous RNAs to regulate the pathological process of temporomandibular joint ...
Huimin Zhu, Yihui Hu, Chuandong Wang, Xiaoling Zhang, D. He   +4 more
semanticscholar   +1 more source

circPTN sponges miR-145-5p/miR-330-5p to promote proliferation and stemness in glioma

Journal of experimental & clinical cancer research : CR, 2019
Growing evidences indicate that circular RNAs (circRNAs) play an important role in the regulation of biological behavior of tumor. We aim to explore the role of circRNA in glioma and elucidate how circRNA acts.
Jiansheng Chen, Taoliang Chen, Yubo Zhu, Yan Li, Yuxuan Zhang, Yun Wang, Xiao Li, X. Xie, Jihui Wang, Min Huang, Xinlin Sun, Yiquan Ke   +11 more
semanticscholar   +1 more source