Results 11 to 20 of about 101,997 (112)

Construction and Identification of Inflammation-Related TF-mRNA-miRNA Coexpression Network and Immune Infiltration in Parkinson's Disease. [PDF]

Parkinsons Dis
Background: Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide. Inflammation, marked by the infiltration of inflammatory mediators and the proliferation of inflammatory cells, is closely linked to PD. This study aims to identify and validate inflammation‐related biomarkers in PD and construct a TF–mRNA–miRNA ...
Shen Z, Zhang J, Jing X, Tao E.
europepmc   +2 more sources

Atopic dermatitis: pathogenesis and therapeutic intervention. [PDF]

MedComm (2020)
Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease, and its complex pathogenesis is closely linked to genetic and environmental factors, skin barrier dysfunction as well as immune dysfunction, which imposes a significant socioeconomic burden in all countries. The compromised function of the skin barrier leads to the release of alarm
Yue C, Zhou H, Wang X, Yu J, Hu Y, Zhou P, Zhao F, Zeng F, Li G, Li Y, Feng Y, Sun X, Huang S, He M, Wu W, Huang N, Li J.   +16 more
europepmc   +2 more sources

Dihydrosterculic acid induces hepatic PPARα target gene expression in mice. [PDF]

J Physiol
Abstract figure legend Proposed mechanisms for the lipid‐reducing phenotype of cottonseed oil (CSO). Increase in PPARα and PPARα target gene expression (A), decrease in SCD1 desaturase activity (B) and increase in energy expenditure in CSO‐fed mice (C). PPARα, peroxisome proliferator‐activated receptor alpha; ACOX1, acyl‐CoA oxidase 1; CPT1A, carnitine
Halls LS, Son Y, Lorenz WW, Shockey J, Heo J, Call JA, Paton CM.   +6 more
europepmc   +2 more sources

A pairwise distance distribution correction (DDC) algorithm to eliminate blinking-caused artifacts in SMLM. [PDF]

Nat Methods, 2021
Bohrer CH, Yang X, Thakur S, Weng X, Tenner B, McQuillen R, Ross B, Wooten M, Chen X, Zhang J, Roberts E, Lakadamyali M, Xiao J.   +12 more
europepmc   +2 more sources

Melanin Synthesis Pathway Interruption: CRISPR/Cas9-mediated Knockout of dopa decarboxylase (DDC) in Harmonia axyridis (Coleoptera: Coccinellidae)

Journal of Insect Science, 2022
CRISPR/Cas9 technology is a very powerful genome editing tool and has been used in many insect species for functional genomics studies through targeted gene mutagenesis.
Meng-meng Wu, Xu Chen, Qingbiao Xu, L. Zang, Su Wang, Ming Li, D. Xiao   +6 more
semanticscholar   +1 more source

In Arabidopsis thaliana Cd differentially impacts on hormone genetic pathways in the methylation defective ddc mutant compared to wild type

Scientific Reports, 2021
DNA methylation plays an important role in modulating plant growth plasticity in response to stress, but mechanisms involved in such control need further investigation.
M. Pacenza, A. Muto, A. Chiappetta, L. Mariotti, E. Talarico, P. Picciarelli, E. Picardi, L. Bruno, M. B. Bitonti   +8 more
semanticscholar   +1 more source

Preclinical In Vitro Studies with 3D Spheroids to Evaluate Cu(DDC)2 Containing Liposomes for the Treatment of Neuroblastoma

Pharmaceutics, 2021
Preclinical in vitro studies of drug candidates for anticancer therapy are generally conducted on well-established 2D cell models. Unfortunately, these models are unable to mimic the properties of in vivo tumors.
F. Hartwig, Monika Köll-Weber, R. Süss
semanticscholar   +1 more source

MicroRNA miR-330-3p suppresses the progression of ovarian cancer by targeting RIPK4

Bioengineered, 2021
Previous studies reported that miR-330-3p was involved in the progression of several cancers, but the potential roles of miR-330-3p in ovarian cancer (OC) were unclear. In the current study, we aimed to explore the expression pattern and functions of miR-
Li Cai, Lu Ye, Xiaoqing Hu, Wen-feng He, Debao Zhuang, Qi Guo, Kuanyong Shu, Youkun Jie   +7 more
semanticscholar   +1 more source

CircHIPK3 Promotes Gemcitabine (GEM) Resistance in Pancreatic Cancer Cells by Sponging miR-330-5p and Targets RASSF1

Cancer Management and Research, 2020
Background Pancreatic cancer is one of the most common malignant diseases in the world. Gemcitabine chemotherapy remains the most important clinical treatment.
Yunfei Liu, L. Xia, Luo Dong, Jiale Wang, Qiangsheng Xiao, Xiao Yu, Hongwei Zhu   +6 more
semanticscholar   +1 more source

CircGCN1L1 promotes synoviocyte proliferation and chondrocyte apoptosis by targeting miR-330-3p and TNF-α in TMJ osteoarthritis

Cell Death and Disease, 2020
Altered expression of circular RNAs (circRNAs) has been identified in various human diseases. In this study, we investigated whether circRNAs function as competing endogenous RNAs to regulate the pathological process of temporomandibular joint ...
Huimin Zhu, Yihui Hu, Chuandong Wang, Xiaoling Zhang, D. He   +4 more
semanticscholar   +1 more source