Results 11 to 20 of about 102,839 (113)

Circ_0008532 promotes bladder cancer progression by regulation of the miR-155-5p/miR-330-5p/MTGR1 axis

Journal of experimental & clinical cancer research : CR, 2020
Background Circular RNAs (circRNAs) have been associated with bladder cancer (BC), but the specific underlying molecular mechanism of their association with BC development has not been fully explored.
Liang Chen, Xiong Yang, Jun Zhao, M. Xiong, Raya Almaraihah, Zhaohui Chen, Teng Hou   +6 more
semanticscholar   +1 more source

Dihydrosterculic acid induces hepatic PPARα target gene expression in mice. [PDF]

J Physiol
Abstract figure legend Proposed mechanisms for the lipid‐reducing phenotype of cottonseed oil (CSO). Increase in PPARα and PPARα target gene expression (A), decrease in SCD1 desaturase activity (B) and increase in energy expenditure in CSO‐fed mice (C). PPARα, peroxisome proliferator‐activated receptor alpha; ACOX1, acyl‐CoA oxidase 1; CPT1A, carnitine
Halls LS, Son Y, Lorenz WW, Shockey J, Heo J, Call JA, Paton CM.   +6 more
europepmc   +2 more sources

Revised Exon Structure of l-DOPA Decarboxylase (DDC) Reveals Novel Splice Variants Associated with Colorectal Cancer Progression

International Journal of Molecular Sciences, 2020
Colorectal cancer (CRC) is a highly heterogenous malignancy with an increased mortality rate. Aberrant splicing is a typical characteristic of CRC, and several studies support the prognostic value of particular transcripts in this malignancy.
P. Artemaki, Maria Papatsirou, Michaela A. Boti, P. Adamopoulos, S. Christodoulou, D. Vassilacopoulou, A. Scorilas, C. Kontos   +7 more
semanticscholar   +1 more source

Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson’s disease

Acta Neuropathologica
Parkinson’s disease (PD) starts at the molecular and cellular level long before motor symptoms appear, yet there are no early-stage molecular biomarkers for diagnosis, prognosis prediction, or monitoring therapeutic response.
J. Rutledge, B. Lehallier, Pardis Zarifkar, P. M. Losada, M. Shahid-Besanti, D. Western, P. Gorijala, S. Ryman, M. Yutsis, Gayle K. Deutsch, E. Mormino, A. Trelle, Anthony D. Wagner, G. Kerchner, Lu Tian, C. Cruchaga, Victor W. Henderson, T. Montine, P. Borghammer, Tony Wyss-Coray, K. Poston   +20 more
semanticscholar   +1 more source

L-Dopa-Decarboxylase (DDC) Is a Positive Prognosticator for Breast Cancer Patients and Epinephrine Regulates Breast Cancer Cell (MCF7 and T47D) Growth In Vitro According to Their Different Expression of Gi- Protein- Coupled Receptors

International Journal of Molecular Sciences, 2020
A coherence between thyroid dysfunction and breast cancer incidence exists. Thyroid hormone metabolites bind to TAAR1 (trace amine-associated receptor 1) and through that modulate the serotonergic and dopaminergic system.
E. Tremmel, C. Kuhn, T. Kaltofen, T. Vilsmaier, D. Mayr, S. Mahner, N. Ditsch, U. Jeschke, A. Vattai   +8 more
semanticscholar   +1 more source

Circ-ZKSCAN1 regulates FAM83A expression and inactivates MAPK signaling by targeting miR-330-5p to promote non-small cell lung cancer progression.

Translational Lung Cancer Research, 2019
Background Circular RNAs (circRNAs) belong to a new type of endogenous non-coding RNA and plays a key role in carcinogenesis. Circ-ZKSCAN1 (hsa_circ_0001727) has been proven to be a tumor-dependent circRNA. However, its role in non-small cell lung cancer
Yuanyong Wang, Rongjian Xu, Dongyang Zhang, T. Lu, Wanpeng Yu, Yang Wo, Ao Liu, Tianyi Sui, Jian Cui, Yi Qin, Yanting Dong, X. Leng, Dezhi Kong, Wenxing Du, Zhangfeng Huang, Wenhao Su, Tianxiang Yuan, Xiao Sun, Jianxun Wang, W. Jiao   +19 more
semanticscholar   +1 more source

Holding a wing horizontal: Roles for muscles of the pectoral girdle other than the main two flight muscles

Journal of Anatomy, EarlyView.
This report explores which muscles of the pectoral girdle are employed to allow birds to hold their wings horizontally with a level aerofoil surface during a glide. Abstract Whilst many birds glide briefly with wings held horizontally, some species maintain this posture for extended periods during soaring.
D. Charles Deeming, María Clelia Mosto
wiley   +1 more source

Nrf2 Ameliorates DDC-Induced Sclerosing Cholangitis and Biliary Fibrosis and Improves the Regenerative Capacity of the Liver.

Toxicological Sciences, 2019
The Nrf2 pathway protects against oxidative stress and induces regeneration of various tissues. Here, we investigated whether Nrf2 protects from sclerosing cholangitis and biliary fibrosis and simultaneously induces liver regeneration.
A. Fragoulis, J. Schenkel, M. Herzog, Tim Schellenberg, H. Jahr, T. Pufe, C. Trautwein, T. Kensler, K. Streetz, C. Wruck   +9 more
semanticscholar   +1 more source

miR-330 Regulates Colorectal Cancer Oncogenesis by Targeting BACH1

Advanced Pharmaceutical Bulletin, 2020
Purpose: Based on WHO report, colorectal cancer (CRC) is the second cause of death among patients with cancer worldwide. Dysregulation of miRNAs expressions has been demonstrated in different human cancers, especially CRC. Studies have shown that miR-330
Solmaz Shirjang, B. Mansoori, A. Mohammadi, Neda Shajari, Pascal H G Duijf, S. Najafi, Fereydoon Abedi Gaballu, K. Nofouzi, B. Baradaran   +8 more
semanticscholar   +1 more source

Ribcage Morphology in Native South American Populations From Different Altitudes: Insights From a Global Comparative Framework

American Journal of Human Biology, Volume 38, Issue 2, February 2026.
ABSTRACT Objectives Altitude shapes human morphology as highland populations must cope with cold and hypoxic environments. Although Andean highlanders have been proposed to exhibit larger and deeper ribcages, this idea is mainly based on research using disarticulated skeletal elements or non‐South American controls. The objective of this research is to
J. M. López‐Rey, M. D. D’Angelo del Campo, G. Bettera Marcat, M. Arrieta, M. Fabra, S. Salega, P. Mercolli, V. Seldes, D. García‐Martínez, M. Bastir   +9 more
wiley   +1 more source