Results 11 to 20 of about 590 (68)

Cannabinoid CB₂ receptor-mediated analgesia: mechanism-based insights and therapeutic potential. [PDF]

Br J Pharmacol
Agonists of the cannabinoid 2 (CB2) receptor have shown promise for the treatment of pain in a variety of animal models. However, despite current preclinical evidence supporting the use of CB2 agonists for pain, successful translation of findings from preclinical models to human patients is lacking.
Guenther KG, Hohmann AG.
europepmc   +2 more sources

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

MARPLE: A Proximity‐Triggered CRISPR‐Cas13 Platform for Ultrasensitive Antibody Detection

Advanced Science, Volume 13, Issue 13, 3 March 2026.
MARPLE is a modular CRISPR‐Cas13 immunoassay that uses antibody‐induced proximity to trigger a toehold‐exchange reaction, releasing an RNA activator for Cas13. This one‐pot, isothermal architecture enables ultrasensitive (femtomolar) and highly specific detection of diverse antibodies, including therapeutic, pathogen‐specific, and cancer‐associated ...
Elena Spezzani, Luca Capelli, Denise Di Lena, Alejandro Chamorro‐Garcia, Rudy Ippodrino, Alessandro Porchetta, Alessandro Bertucci   +6 more
wiley   +1 more source

Ribcage Morphology in Native South American Populations From Different Altitudes: Insights From a Global Comparative Framework

American Journal of Human Biology, Volume 38, Issue 2, February 2026.
ABSTRACT Objectives Altitude shapes human morphology as highland populations must cope with cold and hypoxic environments. Although Andean highlanders have been proposed to exhibit larger and deeper ribcages, this idea is mainly based on research using disarticulated skeletal elements or non‐South American controls. The objective of this research is to
J. M. López‐Rey, M. D. D’Angelo del Campo, G. Bettera Marcat, M. Arrieta, M. Fabra, S. Salega, P. Mercolli, V. Seldes, D. García‐Martínez, M. Bastir   +9 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

Power source, data retrieval method, and attachment type affect success of dorsally mounted tracking tag deployments in 37 species of shorebirds

Journal of Avian Biology, Volume 2025, Issue 6, November 2025.
Animal‐borne trackers are commonly used to study bird movements, including in long‐distance migrants such as shorebirds. Selecting a tracker and attachment method can be daunting, and methodological advancements often have been made by trial and error and conveyed by word of mouth.
Emily L. Weiser, Richard B. Lanctot, Daniel R. Ruthrauff, Sarah T. Saalfeld, T. Lee Tibbitts, José M. Abad‐Gómez, Joaquin Aldabe, Juliana Bosi de Almeida, José A. Alves, Guy Q.A. Anderson, Phil F. Battley, Heinrich Belting, Joël Bêty, Kristin Bianchini, Mary Anne Bishop, Roeland A. Bom, Katharine Bowgen, Glen S. Brown, Stephen C. Brown, Leandro Bugoni, Niall H.K. Burton, David R. Bybee, Camilo Carneiro, Gabriel Castresana, Ying‐Chi Chan, Chi‐Yeung Choi, Katherine S. Christie, Nigel A. Clark, Jesse R. Conklin, Medardo Cruz‐López, Stephen J. Dinsmore, Steve G. Dodd, David C. Douglas, Luke J. Eberhart‐Hertel, Willow B. English, Harry T. Ewing, Fernando A. Faria, Samantha E. Franks, Richard A. Fuller, Robert E. Gill Jr, Marie‐Andrée Giroux, Cheri L. Gratto‐Trevor, David J. Green, Rhys E. Green, Ros M.W. Green, Tómas G. Gunnarsson, Jorge S. Gutiérrez, Autumn‐Lynn Harrison, C. Alex Hartman, Chris J. Hassell, Sarah A. Hoepfner, Jos C. E. W. Hooijmeijer, James A. Johnson, Oscar W. Johnson, Bart Kempenaers, Marcel Klaassen, Eva M.A. Kok, Johannes Krietsch, Clemens Küpper, Andy Y. Kwarteng, Eunbi Kwon, Jean‐Francois Lamarre, Christopher J. Latty, Nicolas Lecomte, A.H. Jelle Loonstra, Zhijun Ma, Lucas Mander, Christopher Marlow, Peter P. Marra, Jose A. Masero, Laura A. McDuffie, Rebecca L. McGuire, Johannes Melter, David S. Melville, Verónica Méndez, Tyler J. Michels, Christy A. Morrissey, Tong Mu, David J. Newstead, Gary W. Page, Allison K. Pierce, Theunis Piersma, Márcio Repenning, Brian H. Robinson, Afonso D. Rocha, Danny I. Rogers, Amy L. Scarpignato, Shiloh Schulte, Emily S. Scragg, Nathan R. Senner, Paul A. Smith, Audrey R. Taylor, Rachel C. Taylor, Böðvar Þórisson, Mihai Valcu, Mo A. Verhoeven, Lena Ware, Nils Warnock, Michael F. Weber, Lucy J. Wright, Michael B. Wunder   +100 more
wiley   +1 more source

Leukocyte count and new‐onset diabetes mellitus in people with HIV: A longitudinal study

HIV Medicine, Volume 26, Issue 10, Page 1585-1599, October 2025.
Abstract Objectives The risk of diabetes mellitus (DM) is increased in people with HIV. Chronic inflammation contributes to DM risk. High leukocytes are associated with DM in the general population, but in people with HIV, evidence of a leukocyte–DM association is limited. Methods We included participants of the Swiss HIV Cohort Study with new‐onset DM
Sophia C. Meyer, Zoe Klein, Isabella C. Schoepf, Christian W. Thorball, Marco Labarile, Neeltje A. Kootstra, Peter Reiss, Lene Ryom, Dominique L. Braun, Maria C. Thurnheer, Catia Marzolini, Christian R. Kahlert, Enos Bernasconi, Matthias Cavassini, Annalisa Marinosci, Jacques Fellay, Huldrych F. Günthard, Roger D. Kouyos, Bruno Ledergerber, Philip E. Tarr, the Swiss HIV Cohort Study, I Abela, K Aebi‐Popp, A Anagnostopoulos, M Battegay, E Bernasconi, DL Braun, HC Bucher, A Calmy, M Cavassini, A Ciuffi, G Dollenmaier, M Egger, L Elzi, J Fehr, J Fellay, H Furrer, CA Fux, HF Günthard, A Hachfeld, D Haerry, B Hasse, HH Hirsch, M Hoffmann, I Hösli, M Huber, D Jackson‐Perry, patient representatives, CR Kahlert, O Keiser, T Klimkait, RD Kouyos, H Kovari, K Kusejko, N Labhardt, K Leuzinger, B Martinez de Tejada, C Marzolini, KJ Metzner, N Müller, J Nemeth, D Nicca, J Notter, P Paioni, G Pantaleo, M Perreau, A Rauch, L Salazar‐Vizcaya, P Schmid, R Speck, M Stöckle, P Tarr, A Trkola, G Wandeler, M Weisser, S. Yerly   +75 more
wiley   +1 more source

Dihydrosterculic acid induces hepatic PPARα target gene expression in mice

The Journal of Physiology, Volume 603, Issue 19, Page 5415-5435, October 1, 2025.
Abstract figure legend Proposed mechanisms for the lipid‐reducing phenotype of cottonseed oil (CSO). Increase in PPARα and PPARα target gene expression (A), decrease in SCD1 desaturase activity (B) and increase in energy expenditure in CSO‐fed mice (C). PPARα, peroxisome proliferator‐activated receptor alpha; ACOX1, acyl‐CoA oxidase 1; CPT1A, carnitine
Leah S. Halls, Yura Son, W. Walter Lorenz, Jay Shockey, Junwon Heo, Jarrod A. Call, Chad M. Paton   +6 more
wiley   +1 more source

Ferroptosis in Cancer and Inflammatory Diseases: Mechanisms and Therapeutic Implications

MedComm, Volume 6, Issue 9, September 2025.
Ferroptosis, a form of cell death driven by iron and lipid peroxidation, serves as a bridge between cancer and inflammatory diseases. Microenvironmental factors such as oxidative stress collectively regulate this process. In cancer, ferroptosis exhibits dual roles: while it eliminates drug‐resistant cells, it may also promote tumor metastasis.
Guangyi Shen, Jiachen Liu, Yinhuai Wang, Zebin Deng, Fei Deng   +4 more
wiley   +1 more source