Results 11 to 20 of about 99,300 (97)

L-Dopa-Decarboxylase (DDC) Is a Positive Prognosticator for Breast Cancer Patients and Epinephrine Regulates Breast Cancer Cell (MCF7 and T47D) Growth In Vitro According to Their Different Expression of Gi- Protein- Coupled Receptors

International Journal of Molecular Sciences, 2020
A coherence between thyroid dysfunction and breast cancer incidence exists. Thyroid hormone metabolites bind to TAAR1 (trace amine-associated receptor 1) and through that modulate the serotonergic and dopaminergic system.
E. Tremmel, C. Kuhn, T. Kaltofen, T. Vilsmaier, D. Mayr, S. Mahner, N. Ditsch, U. Jeschke, A. Vattai   +8 more
semanticscholar   +1 more source

Circ-ZKSCAN1 regulates FAM83A expression and inactivates MAPK signaling by targeting miR-330-5p to promote non-small cell lung cancer progression.

Translational Lung Cancer Research, 2019
Background Circular RNAs (circRNAs) belong to a new type of endogenous non-coding RNA and plays a key role in carcinogenesis. Circ-ZKSCAN1 (hsa_circ_0001727) has been proven to be a tumor-dependent circRNA. However, its role in non-small cell lung cancer
Yuanyong Wang, Rongjian Xu, Dongyang Zhang, T. Lu, Wanpeng Yu, Yang Wo, Ao Liu, Tianyi Sui, Jian Cui, Yi Qin, Yanting Dong, X. Leng, Dezhi Kong, Wenxing Du, Zhangfeng Huang, Wenhao Su, Tianxiang Yuan, Xiao Sun, Jianxun Wang, W. Jiao   +19 more
semanticscholar   +1 more source

miR-330 Regulates Colorectal Cancer Oncogenesis by Targeting BACH1

Advanced Pharmaceutical Bulletin, 2020
Purpose: Based on WHO report, colorectal cancer (CRC) is the second cause of death among patients with cancer worldwide. Dysregulation of miRNAs expressions has been demonstrated in different human cancers, especially CRC. Studies have shown that miR-330
Solmaz Shirjang, B. Mansoori, A. Mohammadi, Neda Shajari, Pascal H G Duijf, Souzan Najafi, Fereydoon Abedi Gaballu, K. Nofouzi, B. Baradaran   +8 more
semanticscholar   +1 more source

Nrf2 Ameliorates DDC-Induced Sclerosing Cholangitis and Biliary Fibrosis and Improves the Regenerative Capacity of the Liver.

Toxicological Sciences, 2019
The Nrf2 pathway protects against oxidative stress and induces regeneration of various tissues. Here, we investigated whether Nrf2 protects from sclerosing cholangitis and biliary fibrosis and simultaneously induces liver regeneration.
A. Fragoulis, J. Schenkel, M. Herzog, Tim Schellenberg, H. Jahr, T. Pufe, C. Trautwein, T. Kensler, K. Streetz, C. Wruck   +9 more
semanticscholar   +1 more source

miR‐330 suppresses EMT and induces apoptosis by downregulating HMGA2 in human colorectal cancer

Journal of Cellular Physiology, 2019
MicroRNAs (miRNAs) are important molecular regulatorsof cellular signaling and behavior. They alter gene expression by targeting messenger RNAs, including those encoding transcriptional regulators, such as HMGA2.
B. Mansoori, A. Mohammadi, Sanaz Naghizadeh, M. Gjerstorff, D. Shanehbandi, Solmaz Shirjang, Souzan Najafi, U. Holmskov, V. Khaze, Pascal H. G. Duijf, B. Baradaran   +10 more
semanticscholar   +1 more source

Analysis of Expression and Functional Activity of Aromatic L-Amino Acid Decarboxylase (DDC) and Serotonin Transporter (SERT) as Potential Sources of Serotonin in Mouse Ovary

International Journal of Molecular Sciences, 2019
The origin of serotonin in the ovary is the key question for understanding mechanisms of serotonergic regulation of reproductive function. We performed a study of the expression and functional activity of the serotonin transporter (SERT) and the enzyme ...
D. A. Nikishin, N. M. Alyoshina, M. Semenova, Y. B. Shmukler   +3 more
semanticscholar   +1 more source

MicroRNA-330-3p promotes brain metastasis and epithelial-mesenchymal transition via GRIA3 in non-small cell lung cancer

Aging, 2019
Brain metastasis (BM) is associated with poor prognosis in patients with non-small cell lung cancer (NSCLC). We sought to identify microRNAs (miRNAs) that could serve as biomarkers to differentiate NSCLC patients with and without BM.
C. Wei, Rui-guang Zhang, Q. Cai, Xican Gao, F. Tong, Ji-hua Dong, Yu Hu, Gang Wu, Xiaorong Dong   +8 more
semanticscholar   +1 more source

Circ_0078767 suppresses non‐small‐cell lung cancer by protecting RASSF1A expression via sponging miR‐330‐3p

Cell Proliferation, 2018
This study was designed to investigate the role of circ_0078767/miR‐330‐3p/RASSF1A in non‐small‐cell lung cancer (NSCLC). Bioinformatic analysis was performed to screen for the differentially expressed genes in NSCLC tissues from adjacent lung tissues.
Ting Chen, Zuozhang Yang, Chao Liu, Li Wang, Jun Yang, Long-Jie Chen, Wenhui Li   +6 more
semanticscholar   +1 more source

Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor

Scientific Reports, 2018
Exportin-1 (XPO1) controls the nucleo-cytoplasmic trafficking of several key growth regulatory and tumor suppressor proteins. Nuclear export blockade through XPO1 inhibition is a target for therapeutic inhibition in many cancers.
V. V. Subhash, V. V. Subhash, M. Yeo, Lingzhi Wang, S. Tan, Foong Ying Wong, W. Thuya, W. Tan, Praveen C. Peethala, M. Soe, D. Tan, Nisha T. Padmanabhan, E. Baloglu, S. Shacham, P. Tan, H. Koeffler, W. Yong   +16 more
semanticscholar   +1 more source

Bone morphogenetic protein 9 as a key regulator of liver progenitor cells in DDC‐induced cholestatic liver injury

Liver international (Print), 2018
Bone morphogenetic protein 9 (BMP9) interferes with liver regeneration upon acute injury, while promoting fibrosis upon carbon tetrachloride‐induced chronic injury. We have now addressed the role of BMP9 in 3,5 diethoxicarbonyl‐1,4 dihydrocollidine (DDC)‐
A. Addante, C. Roncero, L. Almalé, Nerea Lazcanoiturburu, M. García-Álvaro, Margarita Fernández, Julián Sanz, S. Hammad, Z. Nwosu, Se-Jin Lee, I. Fabregat, S. Dooley, P. ten Dijke, B. Herrera, Aránzazu Sánchez   +14 more
semanticscholar   +1 more source