Results 11 to 20 of about 567 (66)

Atopic dermatitis: pathogenesis and therapeutic intervention. [PDF]

MedComm (2020)
Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease, and its complex pathogenesis is closely linked to genetic and environmental factors, skin barrier dysfunction as well as immune dysfunction, which imposes a significant socioeconomic burden in all countries. The compromised function of the skin barrier leads to the release of alarm
Yue C, Zhou H, Wang X, Yu J, Hu Y, Zhou P, Zhao F, Zeng F, Li G, Li Y, Feng Y, Sun X, Huang S, He M, Wu W, Huang N, Li J.   +16 more
europepmc   +2 more sources

Dihydrosterculic acid induces hepatic PPARα target gene expression in mice. [PDF]

J Physiol
Abstract figure legend Proposed mechanisms for the lipid‐reducing phenotype of cottonseed oil (CSO). Increase in PPARα and PPARα target gene expression (A), decrease in SCD1 desaturase activity (B) and increase in energy expenditure in CSO‐fed mice (C). PPARα, peroxisome proliferator‐activated receptor alpha; ACOX1, acyl‐CoA oxidase 1; CPT1A, carnitine
Halls LS, Son Y, Lorenz WW, Shockey J, Heo J, Call JA, Paton CM.   +6 more
europepmc   +2 more sources

Cannabinoid CB2 receptor‐mediated analgesia: mechanism‐based insights and therapeutic potential

British Journal of Pharmacology, Volume 182, Issue 21, Page 5090-5118, November 2025.
Agonists of the cannabinoid 2 (CB2) receptor have shown promise for the treatment of pain in a variety of animal models. However, despite current preclinical evidence supporting the use of CB2 agonists for pain, successful translation of findings from preclinical models to human patients is lacking.
Kelsey G. Guenther, Andrea G. Hohmann
wiley   +1 more source

Leukocyte count and new‐onset diabetes mellitus in people with HIV: A longitudinal study

HIV Medicine, Volume 26, Issue 10, Page 1585-1599, October 2025.
Abstract Objectives The risk of diabetes mellitus (DM) is increased in people with HIV. Chronic inflammation contributes to DM risk. High leukocytes are associated with DM in the general population, but in people with HIV, evidence of a leukocyte–DM association is limited. Methods We included participants of the Swiss HIV Cohort Study with new‐onset DM
Sophia C. Meyer, Zoe Klein, Isabella C. Schoepf, Christian W. Thorball, Marco Labarile, Neeltje A. Kootstra, Peter Reiss, Lene Ryom, Dominique L. Braun, Maria C. Thurnheer, Catia Marzolini, Christian R. Kahlert, Enos Bernasconi, Matthias Cavassini, Annalisa Marinosci, Jacques Fellay, Huldrych F. Günthard, Roger D. Kouyos, Bruno Ledergerber, Philip E. Tarr, the Swiss HIV Cohort Study, I Abela, K Aebi‐Popp, A Anagnostopoulos, M Battegay, E Bernasconi, DL Braun, HC Bucher, A Calmy, M Cavassini, A Ciuffi, G Dollenmaier, M Egger, L Elzi, J Fehr, J Fellay, H Furrer, CA Fux, HF Günthard, A Hachfeld, D Haerry, B Hasse, HH Hirsch, M Hoffmann, I Hösli, M Huber, D Jackson‐Perry, patient representatives, CR Kahlert, O Keiser, T Klimkait, RD Kouyos, H Kovari, K Kusejko, N Labhardt, K Leuzinger, B Martinez de Tejada, C Marzolini, KJ Metzner, N Müller, J Nemeth, D Nicca, J Notter, P Paioni, G Pantaleo, M Perreau, A Rauch, L Salazar‐Vizcaya, P Schmid, R Speck, M Stöckle, P Tarr, A Trkola, G Wandeler, M Weisser, S. Yerly   +75 more
wiley   +1 more source

Ferroptosis in Cancer and Inflammatory Diseases: Mechanisms and Therapeutic Implications

MedComm, Volume 6, Issue 9, September 2025.
Ferroptosis, a form of cell death driven by iron and lipid peroxidation, serves as a bridge between cancer and inflammatory diseases. Microenvironmental factors such as oxidative stress collectively regulate this process. In cancer, ferroptosis exhibits dual roles: while it eliminates drug‐resistant cells, it may also promote tumor metastasis.
Guangyi Shen, Jiachen Liu, Yinhuai Wang, Zebin Deng, Fei Deng   +4 more
wiley   +1 more source

Dual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure

Cell Proliferation, Volume 58, Issue 9, September 2025.
This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.
Defeng Guan, Zhou Chen, Yuhua Zhang, Wenjie Sun, Lifei Li, Xia Huang   +5 more
wiley   +1 more source

Exposing the crumbling justification for absolute prosecutorial discretion in youth filing decisions

Family Court Review, Volume 63, Issue 3, Page 401-414, July 2025.
Abstract Can absolute prosecutorial discretion in youth charging decisions—like that allowed under Title 16 in the District of Columbia—continue to withstand legal, scientific, and policy‐based scrutiny? The recently‐approved Restatement of Children and the Law adds to the weight of authorities casting further doubt on the wisdom of such discretion ...
Nina A. Herth, Chinh Q. Le
wiley   +1 more source

Biomolecular Affinities and Cytotoxicity of Copper(I) and Silver(I) Phosphine–Pyridinyl Complexes Against CACO‐2 and CASKI Cell Lines

European Journal of Inorganic Chemistry, Volume 28, Issue 15, May 28, 2025.
This study reports Copper(I) and Silver(I) complexes with pyridinyl Schiff base ligands and triphenylphosphine. Their DNA/protein binding and in vitro cytotoxicity were evaluated. All complexes intercalated with calf thymus DNA, bound strongly to proteins, and showed notable cytotoxicity against Caco‐2 and Caski cancer cells, highlighting their promise
Adesola A. Adeleke, Miche D. Meyer, Nicole R. S. Sibuyi, Martin O. Onani, Bernard Omondi   +4 more
wiley   +1 more source

Fluorene‐Arylamine Copolymers: Separable Control of Hole Transport and Light Emission Through Composition and Conformation

Journal of Polymer Science, Volume 63, Issue 9, Page 2113-2121, 1 May 2025.
Copolymerization with arylamine initially reduces the mobility of the fluorene homopolymer due to trapping but increases with higher arylamine content, demonstrating that mobility in these copolymers is governed by chemical composition. While fluorene β‐phase conformation plays a minor role in transport, it strongly influences emission.
Nikol T. Lambeva, Saurav Limbu, Ji‐Seon Kim, Donal D. C. Bradley   +3 more
wiley   +1 more source

The pivotal role of mass spectrometry in transition metal‐based photocatalyst research for solar‐driven energy conversion and water purification advancements

Bulletin of the Korean Chemical Society, Volume 46, Issue 4, Page 381-412, April 2025.
This review explores recent advancements in the integration of solar energy conversion and water remediation with mass spectrometry as an analytical technique. We examine Ti‐based photocatalysts for their roles in energy conversion and water purification, utilizing mass spectrometric analysis to evaluate the efficiency of these mechanisms.
Haheun Yoo, Hyojin Hwang, Hyojin Kang, Jeongkwon Kim, Jaebeom Lee   +4 more
wiley   +1 more source