Results 21 to 30 of about 99,300 (97)

miR-330-5p targets SPRY2 to promote hepatocellular carcinoma progression via MAPK/ERK signaling

Oncogenesis, 2018
MicroRNAs (miRNAs) have been identified as critical modulators of cell proliferation and growth, which are the major causes of cancer progression including hepatocellular carcinoma (HCC).
S. Xiao, Meng-yuan Yang, Hao Yang, R. Chang, F. Fang, Lian-yue Yang   +5 more
semanticscholar   +1 more source

HuR counteracts miR-330 to promote STAT3 translation during inflammation-induced muscle wasting

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Proinflammatory diseases, such as cancer, AIDS, and chronic obstructive pulmonary diseases, are often associated with a progressive loss of skeletal muscle tissue, a syndrome also known as cachexia.
Souad Mubaid, Jennifer F Ma, A. Omer, Kholoud Ashour, X. J. Lian, B. J. Sánchez, Samantha J. Robinson, A. Cammas, V. Dormoy-Raclet, S. Di Marco, S. Chittur, S. Tenenbaum, I. Gallouzi   +12 more
semanticscholar   +1 more source

Protective effects of microRNA‐330 on amyloid β‐protein production, oxidative stress, and mitochondrial dysfunction in Alzheimer's disease by targeting VAV1 via the MAPK signaling pathway

Journal of Cellular Biochemistry, 2018
This study aims to explore the effect of miR‐330 targeting VAV1 on amyloid β‐protein (Aβ) production, oxidative stress (OS), and mitochondrial dysfunction in Alzheimer's disease (AD) mice through the MAPK signaling pathway.
Ying Zhou, Zhouling Wang, Wei Li, Hui-ling Hong, Juan Chen, Yi-Li Tian, Zhao Liu   +6 more
semanticscholar   +1 more source

Pivotal roles of Kupffer cells in the progression and regression of DDC-induced chronic cholangiopathy

Scientific Reports, 2018
Kupffer cells (KCs) are key players in maintaining tissue homeostasis and are involved in various liver diseases. However, the roles of KCs in the pathogenesis of cholangiopathy are largely unknown.
Leila Jemail, Masashi Miyao, H. Kotani, C. Kawai, Hirozo Minami, H. Abiru, Keiji Tamaki   +6 more
semanticscholar   +1 more source

HAND2-AS1 inhibits invasion and metastasis of cervical cancer cells via microRNA-330-5p-mediated LDOC1

Cancer Cell International, 2019
Cervical cancer is a serious disease with complicated pathogenesis and thus there is an urgent need to find novel targets for the treatment. Recently, long non-coding RNAs (lncRNAs) have emerged as critical factors in tumorigenesis.
Shengcai Chen, Jing Wang
semanticscholar   +1 more source

Protective effect of green perilla-derived chalcone derivative DDC on amyloid β protein-induced neurotoxicity in primary cortical neurons.

Biological and Pharmaceutical Bulletin, 2019
Amyloid β protein (Aβ) causes neurotoxicity and cognitive impairment in Alzheimer's disease (AD). Oxidative stress is closely related to the pathogenesis of AD.
M. Iwasaki, Naotaka Izuo, Yasuhiko Izumi, Yuki Takada‐Takatori, A. Akaike, T. Kume   +5 more
semanticscholar   +1 more source

miR-330-3p suppresses liver cancer cell migration by targeting MAP2K1.

Oncology Letters, 2019
MicroRNAs, considered as a promising focus for the treatment of tumors, are key regulators of a large number of genes. The aim of the present study was to investigate the biological functions of microRNA (miR)-330-3p in liver cancer as it had been ...
Z. Jin, Baoxing Jia, Ludong Tan, Yahui Liu   +3 more
semanticscholar   +1 more source

lncRNA PCAT6 promotes non-small cell lung cancer cell proliferation, migration and invasion through regulating miR-330-5p

OncoTargets and Therapy, 2018
Background Investigating the roles of lncRNA prostate cancer-associated transcript 6 (PCAT6) in modulating the growth and aggressiveness of non-small-cell lung carcinoma (NSCLC) cell.
L. Cui, Haisheng Xu, Wu Yang, L. Yu
semanticscholar   +1 more source

Targeting of CCBE1 by miR-330-3p in human breast cancer promotes metastasis

British Journal of Cancer, 2017
Background:MicroRNAs (miRs) are involved in the regulation of many processes that contribute to malignancy, including cell proliferation, radiation resistance, invasion and metastasis.
A. Mesci, Xiaoyong Huang, Samira Taeb, S. Jahangiri, Yohan Kim, E. Fokas, J. Bruce, H. Leong, Stanley K. Liu   +8 more
semanticscholar   +1 more source

miR-330-5p suppresses glioblastoma cell proliferation and invasiveness through targeting ITGA5

Bioscience Reports, 2017
The present study intended to investigate the biological effects of miR-330-5p on glioblastoma (GBM) cell proliferation and invasiveness by targeting integrin α5 (ITGA5). The expressions of miR-330-5p and ITGA5 mRNA in GBM cell lines (U87, U251, and U373)
Linsen Feng, Jianhua Ma, Haiming Ji, Yichun Liu, Weixing Hu   +4 more
semanticscholar   +1 more source