Results 81 to 90 of about 99,300 (97)

A spatially-resolved transcriptional atlas of the murine dorsal pons at single-cell resolution. [PDF]

Nat Commun
Nardone S, De Luca R, Zito A, Klymko N, Nicoloutsopoulos D, Amsalem O, Brannigan C, Resch JM, Jacobs CL, Pant D, Veregge M, Srinivasan H, Grippo RM, Yang Z, Zeidel ML, Andermann ML, Harris KD, Tsai LT, Arrigoni E, Verstegen AMJ, Saper CB, Lowell BB.   +21 more
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Lack of EGFR catalytic activity in hepatocytes improves liver regeneration following DDC‐induced cholestatic injury by promoting a pro‐restorative inflammatory response

Journal of Pathology, 2022
Despite the well‐known hepatoprotective role of the epidermal growth factor receptor (EGFR) pathway upon acute damage, its specific actions during chronic liver disease, particularly cholestatic injury, remain ambiguous and unresolved.
Nerea Lazcanoiturburu, Juan García-Sáez, Carlos González-Corralejo, C. Roncero, Julián Sanz, Carlos Martín‐Rodríguez, M. P. Valdecantos, A. Martínez‐Palacián, L. Almalé, P. Bragado, Silvia Calero-Pérez, Almudena Fernández, M. García-Bravo, C. Guerra, L. Montoliu, J. Segovia, Á. Valverde, I. Fabregat, B. Herrera, Aránzazu Sánchez   +19 more
semanticscholar   +1 more source

Geniposide suppresses liver injury in a mouse model of DDC‐induced sclerosing cholangitis

Phytotherapy Research, 2021
Sclerosing cholangitis, characterized by biliary inflammation, fibrosis, and stricturing, remains one of the most challenging conditions of clinical hepatology. Geniposide (GE) has anti‐inflammatory, hepatoprotective, and cholagogic effects.
Min Wen, Yubei Liu, Ruiying Chen, P. He, Feihua Wu, Rui Li, Yining Lin   +6 more
semanticscholar   +1 more source

Purification of L-dopa decarboxylase from rat liver and production of polyclonal and monoclonal antibodies against it.

Journal of Biochemistry (Tokyo), 1987
L-DOPA decarboxylase [DDC, aromatic-L-amino acid carboxyl-lyase, EC 4.1.1.28] was purified 800-fold from rat liver by several column chromatographic steps.
M. Ando-Yamamoto, H. Hayashi, T. Sugiyama, H. Fukui, T. Watanabe, H. Wada   +5 more
semanticscholar   +1 more source

Updated results from phase I dose-escalation study of AMG 330, a bispecific T-cell engager molecule, in patients with relapsed/refractory acute myeloid leukemia (R/R AML).

, 2020
7508Background: In this open label phase 1 dose escalation study, safety, tolerability, pharmacokinetics, pharmacodynamics and preliminary efficacy of AMG 330 were evaluated in patients (pts) with ...
F. Ravandi, R. Walter, M. Subklewe, Veit L. Buecklein, M. Jongen‐Lavrencic, P. Paschka, G. Ossenkoppele, H. Kantarjian, A. Hindoyan, S. Agarwal, T. Dai, S. Khaldoyanidi, A. Stein   +12 more
semanticscholar   +1 more source

DDC-Outlier: Preventing Medication Errors Using Unsupervised Learning

IEEE journal of biomedical and health informatics, 2019
Electronic health records have brought valuable improvements to hospital practices by integrating patient information. In fact, the understanding of these data can prevent mistakes that may put patients’ lives at risk.
H. D. P. D. Santos, A. Ulbrich, Vinicius Woloszyn, Renata Vieira   +3 more
semanticscholar   +1 more source

Long noncoding RNA LEF1‐AS1 silencing suppresses the initiation and development of prostate cancer by acting as a molecular sponge of miR‐330‐5p via LEF1 repression

Journal of Cellular Physiology, 2019
Prostate cancer (PCa) is one of the major cancers affecting males with high mortality around the world. Recent studies have found that some long noncoding RNAs play a critical part in the cellular processes of PCa.
Da-Chuang Liu, Lin-lin Song, Q. Liang, Lin Hao, Zhi-guo Zhang, Conghui Han   +5 more
semanticscholar   +1 more source

LncRNA DGCR5 contributes to CSC‐like properties via modulating miR‐330‐5p/CD44 in NSCLC

Journal of Cellular Physiology, 2018
Non‐coding RNAs can exert significant roles various cancers, including NSCLC. Previously, we indicated that lncRNA DGCR5 can promote lung cancer progression through inhibiting hsa‐mir‐22‐3p.
Ren Wang, H. Dong, Jian Zeng, Jing Pan, Xiao-yan Jin   +4 more
semanticscholar   +1 more source

A 0.3V VDDmin 4+2T SRAM for searching and in-memory computing using 55nm DDC technology

Symposium on VLSI Circuits, 2017
A 4+2T SRAM is proposed that offers searching and logic functions. The cell uses the N-well as the write wordline (WL) and eliminates the access transistors. Decoupled read paths enable reliable multi-word activation for in-memory Boolean logic functions.
Qing Dong, Supreet Jeloka, Mehdi Saligane, Yejoong Kim, Masaru Kawaminami, A. Harada, Satoru Miyoshi, D. Blaauw, D. Sylvester   +8 more
semanticscholar   +1 more source

Revitalizing the Frens Method To Synthesize Uniform, Quasi-Spherical Gold Nanoparticles with Deliberately Regulated Sizes from 2 to 330 nm.

Langmuir, 2016
In this work, we have successfully developed a new and consistent model to describe the growth of gold nanoparticles (Au NPs) via citrate reduction of auric acid (HAuCl4) by carefully assessing the temporal evolution of the NP sizes and surface charges ...
Haibing Xia, Yujiao Xiahou, Peina Zhang, Wenchao Ding, Dayang Wang   +4 more
semanticscholar   +1 more source