Results 11 to 20 of about 683 (66)

The CRISPR-Cas9 knockout DDC SH-SY5Y in vitro model for AADC deficiency provides insight into the pathogenicity of R347Q and L353P variants: a cross-sectional structural and functional analysis. [PDF]

FEBS J
Here, we generated a DDC‐KO cellular model for studying aromatic amino acid decarboxylase (AADC) deficiency. This model was created using CRISPR‐Cas9 in the SH‐SY5Y neuroblastoma cell line and was validated through the absence of the dopamine product and an altered l‐dopa metabolite profile.
Carmona-Carmona CA, Bisello G, Franchini R, Lunardi G, Galavotti R, Perduca M, Ribeiro RP, Belviso BD, Giorgetti A, Caliandro R, Lievens PM, Bertoldi M.   +11 more
europepmc   +2 more sources

Neurotransmitters and Immunity: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets. [PDF]

MedComm (2020)
Role of neurotransmitters in multiple pathological processes. Various neurotransmitters, including ACh, EPI, NE, 5‐HT, histamine, DA, glutamate, GABA, and neuropeptides participate in regulating key pathological events, including tumor proliferation, tumor migration, remodeling of the immune microenvironment, and the development of NDDs and ...
Li G, Li F, Tang Y, Guo S, Yao Y, Fang Y, Zhang B, Jiang Y, Wang J, Wu D, Cheng J, Huang Z, Xin Z, Zhang T.   +13 more
europepmc   +2 more sources

Endothelial NAD+ depletion drives vascular senescence and neuroinflammation via mtDNA‐cGAS/STING‐CD38 signaling in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract BACKGROUND Endothelial dysfunction has emerged as early and pivotal event in Alzheimer's disease (AD), yet the molecular mechanisms linking vascular aging to neuroinflammation remain elusive. METHODS We used APP/PS1 mice and amyloid beta (Aβ)–challenged brain endothelial cells (BECs) to understand the mechanisms of nicotinamide adenine ...
Qing‐Hua Luo, Fang Li, Li Yang, Han‐Qing Pan, Wen‐Ping Zhu, Ping Hu, Chu‐Ming Tao, Min Yin, Si Zhang, Qiu‐Ye Liao, Zhi‐Hao Chen, Hong‐Xin Shu, Xin‐Yi Zhu, Teng‐Feng Yan, Xu Liu, Jiang‐Long Tu, Xin‐Gen Zhu   +16 more
wiley   +1 more source

Navigating the Ethereal Tightrope: The Nanogenerator Manipulates Neurons for Immune Equilibrium

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review explores how nanogenerators modulate neuroimmune responses, offering innovative strategies for treating neurological disorders. By interfacing with neural pathways, they enable precise control of immune activity, especially via vagus nerve stimulation.
Jia Du, Rui Deng, Ya Wu, Hong‐Xia Ren, Zong‐Hong Lin, Yang‐Bao Miao   +5 more
wiley   +1 more source

Isolation, RP‐UHPLC‐ESI‐LIT‐Orbitrap‐MS/MS‐Based Metabolic Profiling and Anticandidal Activity of the Root and Leaf Secondary Metabolites of Monotes Kerstingii Gilg (Dipterocarpaceae)

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
This paper describes the isolation and antifungal activity of secondary metabolites from the leaves and roots of Monotes kerstingii. The distribution of these metabolites in the roots and leaves was achieved through comprehensive RP‐UHPLC‐Orbitrap‐MS and MS/MS analysis.
Sorelle Kache Fotsing, Dominique Ngnintedo, Yanick Kevin Dongmo Melogmo, Alena Soboleva, Kevine Dongmo Jumeta, Bruno Ndjakou Lenta, Fabrice Fekam Boyom, Andrej Frolov, Norbert Arnold, Ludger A. Wessjohann, Norbert Sewald, Bonaventure Tchaleu Ngadjui, Ghislain Wabo Fotso   +12 more
wiley   +1 more source

Antitrust for the fintech era

American Business Law Journal, Volume 63, Issue 1, Page 57-78, Spring 2026.
Abstract The emerging relationship between fintechs and banks has revealed antitrust's antiquation. At one time, scholars predicted that fintechs could democratize banking while providing a critical source of competition. But then banks began to acquire their digital rivals: about 900 acquisitions of fintechs have taken place since 2021.
Gregory Day, Lindsay Sain Jones
wiley   +1 more source

Identification and Distribution of Potentially Azole‐Resistant Airborne Fungi in Outdoor Environments of the Basque Country

Environmental Microbiology Reports, Volume 17, Issue 6, December 2025.
Air samples collected at three areas in each province of the Basque Country (Spain) were incubated at 25°C and 37°C for Sabouraud plates (SAB) and at 37°C for plates supplemented with voriconazol (SAB‐VCZ). The potentially resistant isolates from SAB‐VCZ plates were identified and their abundance and diversity were determined.
Saioa Cendon‐Sanchez, Eduardo Pelegri‐Martinez, Uxue Perez‐Cuesta, Xabier Guruceaga, Andoni Ramirez‐Garcia, Ana Abad‐Diaz‐de‐Cerio, Aitor Rementeria   +6 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +28 more
wiley   +1 more source

Power source, data retrieval method, and attachment type affect success of dorsally mounted tracking tag deployments in 37 species of shorebirds

Journal of Avian Biology, Volume 2025, Issue 6, November 2025.
Animal‐borne trackers are commonly used to study bird movements, including in long‐distance migrants such as shorebirds. Selecting a tracker and attachment method can be daunting, and methodological advancements often have been made by trial and error and conveyed by word of mouth.
Emily L. Weiser, Richard B. Lanctot, Daniel R. Ruthrauff, Sarah T. Saalfeld, T. Lee Tibbitts, José M. Abad‐Gómez, Joaquin Aldabe, Juliana Bosi de Almeida, José A. Alves, Guy Q.A. Anderson, Phil F. Battley, Heinrich Belting, Joël Bêty, Kristin Bianchini, Mary Anne Bishop, Roeland A. Bom, Katharine Bowgen, Glen S. Brown, Stephen C. Brown, Leandro Bugoni, Niall H.K. Burton, David R. Bybee, Camilo Carneiro, Gabriel Castresana, Ying‐Chi Chan, Chi‐Yeung Choi, Katherine S. Christie, Nigel A. Clark, Jesse R. Conklin, Medardo Cruz‐López, Stephen J. Dinsmore, Steve G. Dodd, David C. Douglas, Luke J. Eberhart‐Hertel, Willow B. English, Harry T. Ewing, Fernando A. Faria, Samantha E. Franks, Richard A. Fuller, Robert E. Gill Jr, Marie‐Andrée Giroux, Cheri L. Gratto‐Trevor, David J. Green, Rhys E. Green, Ros M.W. Green, Tómas G. Gunnarsson, Jorge S. Gutiérrez, Autumn‐Lynn Harrison, C. Alex Hartman, Chris J. Hassell, Sarah A. Hoepfner, Jos C. E. W. Hooijmeijer, James A. Johnson, Oscar W. Johnson, Bart Kempenaers, Marcel Klaassen, Eva M.A. Kok, Johannes Krietsch, Clemens Küpper, Andy Y. Kwarteng, Eunbi Kwon, Jean‐Francois Lamarre, Christopher J. Latty, Nicolas Lecomte, A.H. Jelle Loonstra, Zhijun Ma, Lucas Mander, Christopher Marlow, Peter P. Marra, Jose A. Masero, Laura A. McDuffie, Rebecca L. McGuire, Johannes Melter, David S. Melville, Verónica Méndez, Tyler J. Michels, Christy A. Morrissey, Tong Mu, David J. Newstead, Gary W. Page, Allison K. Pierce, Theunis Piersma, Márcio Repenning, Brian H. Robinson, Afonso D. Rocha, Danny I. Rogers, Amy L. Scarpignato, Shiloh Schulte, Emily S. Scragg, Nathan R. Senner, Paul A. Smith, Audrey R. Taylor, Rachel C. Taylor, Böðvar Þórisson, Mihai Valcu, Mo A. Verhoeven, Lena Ware, Nils Warnock, Michael F. Weber, Lucy J. Wright, Michael B. Wunder   +100 more
wiley   +1 more source