Results 11 to 19 of about 19 (19)
The Concise Guide to PHARMACOLOGY 2025/26: Transporters
British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,Stephen P. H. Alexander, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri +28 morewiley +1 more sourcePower source, data retrieval method, and attachment type affect success of dorsally mounted tracking tag deployments in 37 species of shorebirds
Journal of Avian Biology, Volume 2025, Issue 6, November 2025.Animal‐borne trackers are commonly used to study bird movements, including in long‐distance migrants such as shorebirds. Selecting a tracker and attachment method can be daunting, and methodological advancements often have been made by trial and error and conveyed by word of mouth.Emily L. Weiser, Richard B. Lanctot, Daniel R. Ruthrauff, Sarah T. Saalfeld, T. Lee Tibbitts, José M. Abad‐Gómez, Joaquin Aldabe, Juliana Bosi de Almeida, José A. Alves, Guy Q.A. Anderson, Phil F. Battley, Heinrich Belting, Joël Bêty, Kristin Bianchini, Mary Anne Bishop, Roeland A. Bom, Katharine Bowgen, Glen S. Brown, Stephen C. Brown, Leandro Bugoni, Niall H.K. Burton, David R. Bybee, Camilo Carneiro, Gabriel Castresana, Ying‐Chi Chan, Chi‐Yeung Choi, Katherine S. Christie, Nigel A. Clark, Jesse R. Conklin, Medardo Cruz‐López, Stephen J. Dinsmore, Steve G. Dodd, David C. Douglas, Luke J. Eberhart‐Hertel, Willow B. English, Harry T. Ewing, Fernando A. Faria, Samantha E. Franks, Richard A. Fuller, Robert E. Gill Jr, Marie‐Andrée Giroux, Cheri L. Gratto‐Trevor, David J. Green, Rhys E. Green, Ros M.W. Green, Tómas G. Gunnarsson, Jorge S. Gutiérrez, Autumn‐Lynn Harrison, C. Alex Hartman, Chris J. Hassell, Sarah A. Hoepfner, Jos C. E. W. Hooijmeijer, James A. Johnson, Oscar W. Johnson, Bart Kempenaers, Marcel Klaassen, Eva M.A. Kok, Johannes Krietsch, Clemens Küpper, Andy Y. Kwarteng, Eunbi Kwon, Jean‐Francois Lamarre, Christopher J. Latty, Nicolas Lecomte, A.H. Jelle Loonstra, Zhijun Ma, Lucas Mander, Christopher Marlow, Peter P. Marra, Jose A. Masero, Laura A. McDuffie, Rebecca L. McGuire, Johannes Melter, David S. Melville, Verónica Méndez, Tyler J. Michels, Christy A. Morrissey, Tong Mu, David J. Newstead, Gary W. Page, Allison K. Pierce, Theunis Piersma, Márcio Repenning, Brian H. Robinson, Afonso D. Rocha, Danny I. Rogers, Amy L. Scarpignato, Shiloh Schulte, Emily S. Scragg, Nathan R. Senner, Paul A. Smith, Audrey R. Taylor, Rachel C. Taylor, Böðvar Þórisson, Mihai Valcu, Mo A. Verhoeven, Lena Ware, Nils Warnock, Michael F. Weber, Lucy J. Wright, Michael B. Wunder +100 morewiley +1 more sourceFerroptosis in Cancer and Inflammatory Diseases: Mechanisms and Therapeutic Implications
MedComm, Volume 6, Issue 9, September 2025.Ferroptosis, a form of cell death driven by iron and lipid peroxidation, serves as a bridge between cancer and inflammatory diseases. Microenvironmental factors such as oxidative stress collectively regulate this process. In cancer, ferroptosis exhibits dual roles: while it eliminates drug‐resistant cells, it may also promote tumor metastasis.Guangyi Shen, Jiachen Liu, Yinhuai Wang, Zebin Deng, Fei Deng +4 morewiley +1 more sourceDual Role of Natural Killer Cells in Early Pregnancy: Immunopathological Implications and Therapeutic Potential in Recurrent Spontaneous Abortion and Recurrent Implantation Failure
Cell Proliferation, Volume 58, Issue 9, September 2025.This article elaborates on the role of NK cells in early pregnancy from multiple perspectives, including molecular mechanisms and therapeutic interventions. It also discusses how NK cell dysfunction contributes to RSA and RIF, aiming to provide insights for future research on NK cell mechanisms and clinical treatment of RSA and RIF.Defeng Guan, Zhou Chen, Yuhua Zhang, Wenjie Sun, Lifei Li, Xia Huang +5 morewiley +1 more sourceThe CRISPR‐Cas9 knockout DDC SH‐SY5Y in vitro model for AADC deficiency provides insight into the pathogenicity of R347Q and L353P variants: a cross‐sectional structural and functional analysis
The FEBS Journal, Volume 292, Issue 18, Page 4833-4853, September 2025.Here, we generated a DDC‐KO cellular model for studying aromatic amino acid decarboxylase (AADC) deficiency. This model was created using CRISPR‐Cas9 in the SH‐SY5Y neuroblastoma cell line and was validated through the absence of the dopamine product and an altered l‐dopa metabolite profile.Cristian Andres Carmona‐Carmona, Giovanni Bisello, Rossella Franchini, Gianluigi Lunardi, Roberta Galavotti, Massimiliano Perduca, Rui P. Ribeiro, Benny Danilo Belviso, Alejandro Giorgetti, Rocco Caliandro, Patricia M.‐J. Lievens, Mariarita Bertoldi +11 morewiley +1 more sourceBiomolecular Affinities and Cytotoxicity of Copper(I) and Silver(I) Phosphine–Pyridinyl Complexes Against CACO‐2 and CASKI Cell Lines
European Journal of Inorganic Chemistry, Volume 28, Issue 15, May 28, 2025.This study reports Copper(I) and Silver(I) complexes with pyridinyl Schiff base ligands and triphenylphosphine. Their DNA/protein binding and in vitro cytotoxicity were evaluated. All complexes intercalated with calf thymus DNA, bound strongly to proteins, and showed notable cytotoxicity against Caco‐2 and Caski cancer cells, highlighting their promise Adesola A. Adeleke, Miche D. Meyer, Nicole R. S. Sibuyi, Martin O. Onani, Bernard Omondi +4 morewiley +1 more source