Results 11 to 20 of about 49,613 (116)
Neurotransmitters and Immunity: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets. [PDF]
MedComm (2020)Role of neurotransmitters in multiple pathological processes. Various neurotransmitters, including ACh, EPI, NE, 5‐HT, histamine, DA, glutamate, GABA, and neuropeptides participate in regulating key pathological events, including tumor proliferation, tumor migration, remodeling of the immune microenvironment, and the development of NDDs and ...
Li G +13 more
europepmc +2 more sources
Atopic dermatitis: pathogenesis and therapeutic intervention. [PDF]
MedComm (2020)Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease, and its complex pathogenesis is closely linked to genetic and environmental factors, skin barrier dysfunction as well as immune dysfunction, which imposes a significant socioeconomic burden in all countries. The compromised function of the skin barrier leads to the release of alarm
Yue C +16 more
europepmc +2 more sources
TNF-alpha-induced microglia activation requires miR-342: impact on NF-kB signaling and neurotoxicity
Cell Death and Disease, 2020 Growing evidences suggest that sustained neuroinflammation, caused by microglia overactivation, is implicated in the development and aggravation of several neurological and psychiatric disorders.
J. P. Brás +6 more
semanticscholar +1 more source
MiR‐342 controls Mycobacterium tuberculosis susceptibility by modulating inflammation and cell death
EMBO Reports, 2021 Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (Mtb) that places a heavy strain on public health. Host susceptibility to Mtb is modulated by macrophages, which regulate the balance between cell apoptosis and necrosis ...
Beibei Fu +16 more
semanticscholar +1 more source
Cell Death and Disease, 2021 Chronic myeloid leukemia (CML) is a myeloproliferative disorder associated with the Philadelphia chromosome, and the current standard of care is the use of tyrosine kinase inhibitors (TKI). However, some patients will not achieve a molecular response and
Yi-Ying Wu +13 more
semanticscholar +1 more source
MicroRNA-342-3p is a potent tumour suppressor in hepatocellular carcinoma.
Journal of Hepatology, 2020 BACKGROUND & AIMS Hepatocellular carcinoma (HCC) is a cancer with multiple etiologies, and widespread prevalence. Largely refractory to current treatments, HCC is the fourth leading cause of cancer related deaths, world-wide.
Ronja-Melinda Komoll +13 more
semanticscholar +1 more source
Tumor Suppressive Role of miR-342-5p in Human Chondrosarcoma Cells and 3D Organoids
International Journal of Molecular Sciences, 2021 Chondrosarcomas are malignant bone tumors. Their abundant cartilage-like extracellular matrix and their hypoxic microenvironment contribute to their resistance to chemotherapy and radiotherapy, and no effective therapy is currently available.
C. Veys +11 more
semanticscholar +1 more source
The U2AF2 /circRNA ARF1/miR-342–3p/ISL2 feedback loop regulates angiogenesis in glioma stem cells
Journal of experimental & clinical cancer research : CR, 2020 Glioma is the most common and lethal primary brain tumor in adults, and angiogenesis is one of the key factors contributing to its proliferation, aggressiveness, and malignant transformation. However, the discovery of novel oncogenes and the study of its
Yang Jiang +9 more
semanticscholar +1 more source
Aging, 2020 Exosomes are reported to mediate several disease-related microRNAs (miRNAs) to affect the progression of diseases, including atherosclerosis. Here, we aimed to screen the atherosclerosis-associated miRNAs and preliminarily investigate the potential ...
Xiaohui Xing +9 more
semanticscholar +1 more source
Acta NeuropathologicaParkinson’s disease (PD) starts at the molecular and cellular level long before motor symptoms appear, yet there are no early-stage molecular biomarkers for diagnosis, prognosis prediction, or monitoring therapeutic response.
J. Rutledge +20 more
semanticscholar +1 more source