Results 1 to 10 of about 540 (68)
Accumulation of Damaging Lipids in the Arf1-Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia. [PDF]
Adv Sci (Weinh)Arf1 defects activate the AKT‐mTORC1‐SREBP1‐FASN pathway to increase lipid synthesis and disrupt ER‐mitochondrial‐lysosomal homeostasis in neurons. Impaired mitochondria secrete damaged mtDNA via mitochondria‐derived extracellular vesicles, which is phagocytosed by the microglia and activated inflammation signaling.
Li X +10 more
europepmc +2 more sources
Interleukin‐7 improves the fitness of regulatory T cells for adoptive transfer
Immunology, Volume 170, Issue 4, Page 540-552, December 2023., 2023 Regulatory T cell (Treg) expanded in the presence of interleukin‐7 (IL‐7, IL‐7M) display a CD45RA+CD62L+CD95+ phenotype and are less suppressive that Treg expanded with the standard method (StM). Once infused in vivo IL‐7M‐Treg persist longer and showed similar suppressive activity compared to StM‐Treg.
Ilaria Cosorich +8 more
wiley +1 more source
The Concise Guide to PHARMACOLOGY 2023/24: Enzymes
British Journal of Pharmacology, Volume 180, Issue S2, Page S289-S373, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander +28 more
wiley +1 more source
The Concise Guide to PHARMACOLOGY 2023/24: Transporters
British Journal of Pharmacology, Volume 180, Issue S2, Page S374-S469, October 2023., 2023 The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander +27 more
wiley +1 more source
Liver International, Volume 43, Issue 7, Page 1427-1439, July 2023., 2023 Abstract Background and Aims People living with HIV (PLWH) are at high risk for advanced chronic liver disease and related adverse outcomes. We aimed to validate the prognostic value of non‐invasive scores based on liver stiffness measurement (LSM) and on markers of portal hypertension (PH), namely platelets and spleen diameter, in PLWH.
Amine Benmassaoud +27 more
wiley +1 more source
Food Science &Nutrition, Volume 11, Issue 6, Page 3558-3574, June 2023., 2023 Long‐horned grasshoppers are consumed in over 21 African countries. Crude protein (28%–45%), crude fat (41%–54%), and energy (582–644 Kj/100 g) of grasshoppers are comparable to that of plant and animal origins. Grasshopper meal could be considered as functional food ingredients capable of supplying adequate essential macro‐ and micronutrients ...
Margaret Kababu +4 more
wiley +1 more source
Sanctions, National Security, and Free Speech
Global Policy, EarlyView.ABSTRACT A fundamental, but largely overlooked, aspect of the New Washington Consensus is the use of national security arguments to restrict speech and punish disfavored speakers. Although the United States has a longer history of using sanctions to restrict speech in the terrorism context, it has recently applied sanctions to restrict political speech,
Joshua Andresen
wiley +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Enzymes
British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +31 more
wiley +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: Transporters
British Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +28 more
wiley +1 more source
UEG Week 2023 Moderated Posters
, 2023 United European Gastroenterology Journal, Volume 11, Issue S8, Page 201-534, October 2023.
wiley +1 more source