Results 1 to 10 of about 483 (69)

Guidelines for mouse and human DC functional assays

open access: yesEuropean Journal of Immunology, Volume 53, Issue 12, December 2023., 2023
Conventional DC (cDC) represent a heterogenous family of professional antigen‐presenting cells. Basic functions common to all tissue‐resident cDC include antigen uptake, lymph node migration, and naive T cell priming to induce appropriate effector and regulatory T cell responses.
Björn E. Clausen   +45 more
wiley   +1 more source

Prodromal Parkinson's disease and the catecholaldehyde hypothesis: Insight from olfactory bulb organotypic cultures

open access: yesThe FASEB Journal, Volume 37, Issue 12, December 2023., 2023
Olfactory dysfunction is one of the most prevalent symptoms of Parkinson's disease preceding clinical onset by up to a decade. However, PD models focus mainly on motor symptoms and nigrostriatal degeneration. Here, we characterize cultured olfactory bulb organotypic slices and cells and explore the effect of DOPAL, a metabolite of dopamine.
Enrico Bagnoli   +6 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2023/24: Enzymes

open access: yesBritish Journal of Pharmacology, Volume 180, Issue S2, Page S289-S373, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander   +28 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2023/24: Transporters

open access: yesBritish Journal of Pharmacology, Volume 180, Issue S2, Page S374-S469, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander   +27 more
wiley   +1 more source

Sexually dimorphic oxytocin receptor‐expressing (OXTR) neurons in the anteroventral periventricular nucleus (AVPV) in the postpartum female mouse are involved in maternal behavior

open access: yesJournal of Neuroendocrinology, Volume 35, Issue 10, October 2023., 2023
The purpose of the present study was to understand the function of sexually dimorphic OXTR neurons. The study revealed that the activity of the sexually dimorphic OXTR neurons is necessary for maternal behavior in female mice. Abstract Maternal care is crucial for the survival and development of offspring.
Kaustubh Sharma   +5 more
wiley   +1 more source

Generative adversarial networks applied to gene expression analysis: An interdisciplinary perspective

open access: yesComputational and Systems Oncology, Volume 3, Issue 3, September 2023., 2023
Abstract The remarkable flexibility and adaptability of generative adversarial networks (GANs) have led to the proliferation of its models in bioinformatics research. Proteomic and transcriptomic profiles have been shown to be promising methods for discovering and identifying disease biomarkers.
Xusheng Ai   +2 more
wiley   +1 more source

Thermal extraction and characterization of pectin from semi‐solid by‐products of the olive oil industry

open access: yesJournal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND The valorization of agro‐industrial by‐products is crucial for promoting sustainability and circular economy. Olive mill semi‐solid by‐products (OMSbP), also known as alperujo, contain valuable bioactive compounds, including pectin, which can be extracted and used in food applications.
Africa Fernandez‐Prior   +6 more
wiley   +1 more source

Evaluating the Therapeutic Potential of Superoxide Dismutase in a Rat Model of Wet Age‐Related Macular Degeneration

open access: yesFASEB BioAdvances, Volume 7, Issue 6, June 2025.
Oral Superoxide Dismutase Therapy Mitigates Choroidal Neovascularization in a Laser‐Induced Rat Model of Wet Age‐Related Macular Degeneration. Oral Administration of GF103, a Superoxide Dismutase From Bacillus amyloliquefaciens, Reduces Choroidal Neovascularization (CNV) in a Laser‐Induced CNV Rat Model.
Hyun Chul Jeong   +4 more
wiley   +1 more source

Deep Learning‐Enhanced Chemiluminescence Vertical Flow Assay for High‐Sensitivity Cardiac Troponin I Testing

open access: yesSmall, Volume 21, Issue 11, March 19, 2025.
This study presents a chemiluminescence vertical flow assay (CL‐VFA) for high‐sensitivity detection of cardiac troponin I (cTnI), a critical biomarker for assessing myocardial infarction. By integrating innovations in CL‐based sensing, portable reader‐based imaging, and deep learning analysis, the CL‐VFA achieves rapid, cost‐effective, and precise ...
Gyeo‐Re Han   +13 more
wiley   +1 more source

Allopolyploidization events and immense paleogenome reshuffling underlying the diversification of plants and secondary metabolites in Oleaceae

open access: yesJournal of Systematics and Evolution, Volume 63, Issue 2, Page 208-228, March 2025.
In this study, we revealed the frequent allopolyploidization events and immense paleogenome reshuffling during the diversification of plants in Oleaceae. At the same time, we explored the effects of these ancient evolutionary events on the synthesis of specific secondary metabolites and environmental adaptability of extant plants from Oleaceae ...
Jiaqi Wang   +13 more
wiley   +1 more source

Home - About - Disclaimer - Privacy