Results 11 to 20 of about 61,620 (96)

A molecular phylogeny of Noctuini (Lepidoptera: Noctuidae: Noctuinae)

Insect Systematics and Diversity, 2023
The tribe Noctuini is comprised over 520 species; many are economically important species that impact human agriculture. Despite their diversity and relevance, relationships of Noctuini have been difficult to resolve.
Melissa S Sisson, Matthew J Flom, Janna L Crossley, Rebecca Simmons   +3 more
semanticscholar   +1 more source

Melanin Synthesis Pathway Interruption: CRISPR/Cas9-mediated Knockout of dopa decarboxylase (DDC) in Harmonia axyridis (Coleoptera: Coccinellidae)

Journal of Insect Science, 2022
CRISPR/Cas9 technology is a very powerful genome editing tool and has been used in many insect species for functional genomics studies through targeted gene mutagenesis.
Meng-meng Wu, Xu Chen, Qingbiao Xu, L. Zang, Su Wang, Ming Li, D. Xiao   +6 more
semanticscholar   +1 more source

NVL-520 Is a Selective, TRK-Sparing, and Brain-Penetrant Inhibitor of ROS1 Fusions and Secondary Resistance Mutations

Cancer Discovery, 2022
NVL-520, a selective macrocyclic inhibitor of ROS1, demonstrated antitumor activity in patient case studies of ROS1 inhibitor–refractory lung cancers without observed neurologic toxicities attributed to TRK inhibition.
A. Drilon, J. Horan, A. Tangpeerachaikul, B. Besse, S. Ou, S. Gadgeel, D. Camidge, A. van der Wekken, Linh Nguyen-Phuong, Adam Acker, Clare Keddy, K. Nicholson, S. Yoda, S. Mente, Yuting Sun, J. Soglia, N. Kohl, J. Porter, M. Shair, V. Zhu, M. Davare, A. Hata, H. Pelish, Jessica J. Lin   +23 more
semanticscholar   +1 more source

Preclinical In Vitro Studies with 3D Spheroids to Evaluate Cu(DDC)2 Containing Liposomes for the Treatment of Neuroblastoma

Pharmaceutics, 2021
Preclinical in vitro studies of drug candidates for anticancer therapy are generally conducted on well-established 2D cell models. Unfortunately, these models are unable to mimic the properties of in vivo tumors.
F. Hartwig, Monika Köll-Weber, R. Süss
semanticscholar   +1 more source

RNA Interference Therapy With ARC‐520 Results in Prolonged Hepatitis B Surface Antigen Response in Patients With Chronic Hepatitis B Infection

Hepatology, 2020
ARC‐520, the first an RNA interference (RNAi) therapeutic, was designed to reduce all RNA transcripts derived from covalently closed circular DNA, leading to a reduction in viral antigens and hepatitis B virus (HBV) DNA.
M. Yuen, I. Schiefke, Jung‐Hwan Yoon, S. Ahn, J. Heo, Ju ng-Hyun Kim, H. Chan, K. Yoon, H. Klinker, M. Manns, J. Petersen, T. Schluep, J. Hamilton, B. Given, C. Ferrari, Ching‐lung Lai, S. Locarnini, R. Gish   +17 more
semanticscholar   +1 more source

Revised Exon Structure of l-DOPA Decarboxylase (DDC) Reveals Novel Splice Variants Associated with Colorectal Cancer Progression

International Journal of Molecular Sciences, 2020
Colorectal cancer (CRC) is a highly heterogenous malignancy with an increased mortality rate. Aberrant splicing is a typical characteristic of CRC, and several studies support the prognostic value of particular transcripts in this malignancy.
P. Artemaki, Maria Papatsirou, Michaela A. Boti, P. Adamopoulos, S. Christodoulou, D. Vassilacopoulou, A. Scorilas, C. Kontos   +7 more
semanticscholar   +1 more source

L-Dopa-Decarboxylase (DDC) Is a Positive Prognosticator for Breast Cancer Patients and Epinephrine Regulates Breast Cancer Cell (MCF7 and T47D) Growth In Vitro According to Their Different Expression of Gi- Protein- Coupled Receptors

International Journal of Molecular Sciences, 2020
A coherence between thyroid dysfunction and breast cancer incidence exists. Thyroid hormone metabolites bind to TAAR1 (trace amine-associated receptor 1) and through that modulate the serotonergic and dopaminergic system.
E. Tremmel, C. Kuhn, T. Kaltofen, T. Vilsmaier, D. Mayr, S. Mahner, N. Ditsch, U. Jeschke, A. Vattai   +8 more
semanticscholar   +1 more source

A Study on the Bibliographic Records and the Expansion of Library Catalog Using Open API

, 2009
In this study, the present condition of 8 Open APIs for books, such as Naver, Daum, Aladdin, Amazon, Google, KERIS, LibraryThing, and OCLC, were compared an d analyzed. In addition, the bibliographic records of 167 samples of visible ‘light & pa raphotic’
J. Gu, Eung-Bong Lee
semanticscholar   +1 more source

100 m/500 Mbps underwater optical wireless communication using an NRZ-OOK modulated 520 nm laser diode.

Optics Express, 2019
In this paper, we proposed and experimentally demonstrated a long-distance high-speed underwater optical wireless communication (UOWC) system in a laboratory environment by using a low-cost green laser diode (LD) and power-efficient non-return-to-zero on-
Jiemei Wang, Chunhui Lu, Shangbin Li, Zhengyuan Xu   +3 more
semanticscholar   +1 more source

Nrf2 Ameliorates DDC-Induced Sclerosing Cholangitis and Biliary Fibrosis and Improves the Regenerative Capacity of the Liver.

Toxicological Sciences, 2019
The Nrf2 pathway protects against oxidative stress and induces regeneration of various tissues. Here, we investigated whether Nrf2 protects from sclerosing cholangitis and biliary fibrosis and simultaneously induces liver regeneration.
A. Fragoulis, J. Schenkel, M. Herzog, Tim Schellenberg, H. Jahr, T. Pufe, C. Trautwein, T. Kensler, K. Streetz, C. Wruck   +9 more
semanticscholar   +1 more source