Results 11 to 20 of about 506 (68)

Neurotransmitters and Immunity: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets. [PDF]

open access: yesMedComm (2020)
Role of neurotransmitters in multiple pathological processes. Various neurotransmitters, including ACh, EPI, NE, 5‐HT, histamine, DA, glutamate, GABA, and neuropeptides participate in regulating key pathological events, including tumor proliferation, tumor migration, remodeling of the immune microenvironment, and the development of NDDs and ...
Li G   +13 more
europepmc   +2 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

open access: yesBritish Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander   +31 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

open access: yesBritish Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander   +28 more
wiley   +1 more source

Characterization of a Bioprinted Anticancer Cell Therapy System Generated with Continuous Liquid Interface Production

open access: yesAdvanced NanoBiomed Research, Volume 5, Issue 10, October 2025.
Cell therapies often fail in the clinic due to poor in vivo persistence. In this study, we developed a 3D bioprinting strategy using continuous liquid interface production (CLIP) to generate cell therapy delivery systems. We provide a robust characterization of this new technique, demonstrating the positive effect of CLIP bioprinting on the efficacy of
Lauren Kass   +6 more
wiley   +1 more source

Metformin and insulin exacerbate one‐carbon metabolism deficits in pregnant growth restricted rats and impacts the placenta, fetal liver and pancreas

open access: yesThe Journal of Physiology, Volume 603, Issue 19, Page 5751-5775, October 1, 2025.
Abstract figure legend Uteroplacental insufficiency (growth restricted) or sham (Control) surgery was performed on embryonic day (E)18 in Wistar–Kyoto rats. Female F1 offspring were mated and restricted dams received daily metformin, insulin or vehicle from E13.
Dayna A. Zimmerman   +11 more
wiley   +1 more source

Ferroptosis in Cancer and Inflammatory Diseases: Mechanisms and Therapeutic Implications

open access: yesMedComm, Volume 6, Issue 9, September 2025.
Ferroptosis, a form of cell death driven by iron and lipid peroxidation, serves as a bridge between cancer and inflammatory diseases. Microenvironmental factors such as oxidative stress collectively regulate this process. In cancer, ferroptosis exhibits dual roles: while it eliminates drug‐resistant cells, it may also promote tumor metastasis.
Guangyi Shen   +4 more
wiley   +1 more source

Plastoquinone redox status influences carboxysome integrity via a RpaA‐ and reactive oxygen species‐dependent regulatory network

open access: yesThe Plant Journal, Volume 123, Issue 6, September 2025.
SUMMARY Carboxysomes are bacterial microcompartments that encapsulate Rubisco and are a core component of the cyanobacterial carbon concentration mechanism (CCM). While carboxysome number, size, and spatial organization vary in different environmental conditions (CO2, light availability, redox state, temperature, and light quality), the molecular ...
María Santos‐Merino   +4 more
wiley   +1 more source

Thermal extraction and characterization of pectin from semi‐solid by‐products of the olive oil industry

open access: yesJournal of the Science of Food and Agriculture, Volume 105, Issue 11, Page 5863-5873, 30 August 2025.
Abstract BACKGROUND The valorization of agro‐industrial by‐products is crucial for promoting sustainability and circular economy. Olive mill semi‐solid by‐products (OMSbP), also known as alperujo, contain valuable bioactive compounds, including pectin, which can be extracted and used in food applications.
Africa Fernandez‐Prior   +6 more
wiley   +1 more source

Evaluating the Therapeutic Potential of Superoxide Dismutase in a Rat Model of Wet Age‐Related Macular Degeneration

open access: yesFASEB BioAdvances, Volume 7, Issue 6, June 2025.
Oral Superoxide Dismutase Therapy Mitigates Choroidal Neovascularization in a Laser‐Induced Rat Model of Wet Age‐Related Macular Degeneration. Oral Administration of GF103, a Superoxide Dismutase From Bacillus amyloliquefaciens, Reduces Choroidal Neovascularization (CNV) in a Laser‐Induced CNV Rat Model.
Hyun Chul Jeong   +4 more
wiley   +1 more source

Deep Learning‐Enhanced Chemiluminescence Vertical Flow Assay for High‐Sensitivity Cardiac Troponin I Testing

open access: yesSmall, Volume 21, Issue 11, March 19, 2025.
This study presents a chemiluminescence vertical flow assay (CL‐VFA) for high‐sensitivity detection of cardiac troponin I (cTnI), a critical biomarker for assessing myocardial infarction. By integrating innovations in CL‐based sensing, portable reader‐based imaging, and deep learning analysis, the CL‐VFA achieves rapid, cost‐effective, and precise ...
Gyeo‐Re Han   +13 more
wiley   +1 more source

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