Results 11 to 20 of about 454 (64)

Development of In Vitro Parkinson's Disease Model Mediated by MPP+ and α-Synuclein Using Wharton's Jelly Mesenchymal Stem Cells. [PDF]

CNS Neurosci Ther
A cost‐effective and rapid in vitro model of Parkinson's disease was created using Wharton's Jelly‐derived mesenchymal stem cells by employing MPP+ iodide or A53T mutated α‐synuclein. ABSTRACT Main Problem The mechanism behind Parkinson's disease (PD) is still unclear, and a cure to stop its progression is yet to be found.
Gamit N, Patil M, Soumya BS, Dharmarajan A, Warrier S.   +4 more
europepmc   +2 more sources

Cost analysis of intrauterine balloon tamponade versus uterine artery embolization in the management of persistent postpartum hemorrhage. [PDF]

Int J Gynaecol Obstet
Abstract Objective The aim of this study was to compare the cost of a strategy initially resorting to intrauterine balloon tamponade versus a strategy initially resorting to uterine artery embolization in the management pathway of persistent postpartum hemorrhage.
Bonsen LR, van den Akker-van Marle ME, Caram-Deelder C, Ramler PI, de Groot CJM, Urlings T, van den Akker T, van der Bom JG, Henriquez DDCA, TeMpOH‐1 study group.   +9 more
europepmc   +2 more sources

Neurotransmitters and Immunity: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets. [PDF]

MedComm (2020)
Role of neurotransmitters in multiple pathological processes. Various neurotransmitters, including ACh, EPI, NE, 5‐HT, histamine, DA, glutamate, GABA, and neuropeptides participate in regulating key pathological events, including tumor proliferation, tumor migration, remodeling of the immune microenvironment, and the development of NDDs and ...
Li G, Li F, Tang Y, Guo S, Yao Y, Fang Y, Zhang B, Jiang Y, Wang J, Wu D, Cheng J, Huang Z, Xin Z, Zhang T.   +13 more
europepmc   +2 more sources

Guidelines for mouse and human DC functional assays

European Journal of Immunology, Volume 53, Issue 12, December 2023., 2023
Conventional DC (cDC) represent a heterogenous family of professional antigen‐presenting cells. Basic functions common to all tissue‐resident cDC include antigen uptake, lymph node migration, and naive T cell priming to induce appropriate effector and regulatory T cell responses.
Björn E. Clausen, Lukas Amon, Ronald A. Backer, Luciana Berod, Tobias Bopp, Anna Brand, Sven Burgdorf, Luxia Chen, Meihong Da, Ute Distler, Regine J. Dress, Diana Dudziak, Charles‐Antoine Dutertre, Christina Eich, Anna Gabele, Melanie Geiger, Florent Ginhoux, Lucila Giusiano, Gloria J. Godoy, Ahmed E.I. Hamouda, Lukas Hatscher, Lukas Heger, Gordon F. Heidkamp, Lola C. Hernandez, Lukas Jacobi, Tomasz Kaszubowski, Wan Ting Kong, Christian H. K. Lehmann, Tamara López‐López, Karsten Mahnke, Dominik Nitsche, Jörg Renkawitz, Rifat A. Reza, Pablo J. Sáez, Laura Schlautmann, Madeleine T. Schmitt, Anna Seichter, Malte Sielaff, Tim Sparwasser, Patrizia Stoitzner, Giorgi Tchitashvili, Stefan Tenzer, Nounagnon R. Tochoedo, Damir Vurnek, Fabian Zink, Thomas Hieronymus   +45 more
wiley   +1 more source

Prodromal Parkinson's disease and the catecholaldehyde hypothesis: Insight from olfactory bulb organotypic cultures

The FASEB Journal, Volume 37, Issue 12, December 2023., 2023
Olfactory dysfunction is one of the most prevalent symptoms of Parkinson's disease preceding clinical onset by up to a decade. However, PD models focus mainly on motor symptoms and nigrostriatal degeneration. Here, we characterize cultured olfactory bulb organotypic slices and cells and explore the effect of DOPAL, a metabolite of dopamine.
Enrico Bagnoli, Alexandre Trotier, Jill McMahon, Leo R. Quinlan, Manus Biggs, Abhay Pandit, Una FitzGerald   +6 more
wiley   +1 more source

Guidelines for mouse and human DC generation

European Journal of Immunology, Volume 53, Issue 11, November 2023., 2023
The article on DC generation is part of the DC Guidelines article collection providing methods for the isolation of mouse and human cellular sources that can be cultured with different growth factors to generate the known subsets of DC. Abstract This article is part of the Dendritic Cell Guidelines article series, which provides a collection of state ...
Manfred B. Lutz, Shafaqat Ali, Cindy Audiger, Stella E. Autenrieth, Luciana Berod, Venetia Bigley, Laura Cyran, Marc Dalod, Jan Dörrie, Diana Dudziak, Georgina Flórez‐Grau, Lucila Giusiano, Gloria J. Godoy, Marion Heuer, Anne B. Krug, Christian H. K. Lehmann, Christian T. Mayer, Shalin H. Naik, Stefanie Scheu, Gerty Schreibelt, Elodie Segura, Kristin Seré, Tim Sparwasser, Jurjen Tel, Huaming Xu, Martin Zenke   +25 more
wiley   +1 more source

Guidelines for preparation and flow cytometry analysis of human nonlymphoid tissue DC. [PDF]

Eur J Immunol
We here provide detailed protocols for isolating single cell suspension from human nonlymphoid tissues, such as gingiva, lung, intestine, skin, and different tumor tissues as well as tumor‐draining lymph nodes. Further, we provide gating strategies for flow cytometric analysis of human DC subpopulations in diverse nonlymphoid tissues.
Dudziak D, Heger L, Agace WW, Bakker J, de Gruijl TD, Dress RJ, Dutertre CA, Fenton TM, Fransen MF, Ginhoux F, Heyman O, Horev Y, Hornsteiner F, Kandiah V, Kles P, Lubin R, Mizraji G, Prokopi A, Saar O, Sopper S, Stoitzner P, Strandt H, Sykora MM, Toffoli EC, Tripp CH, van Pul K, van de Ven R, Wilensky A, Yona S, Zelle-Rieser C.   +29 more
europepmc   +2 more sources

Antitrust for the fintech era

American Business Law Journal, Volume 63, Issue 1, Page 57-78, Spring 2026.
Abstract The emerging relationship between fintechs and banks has revealed antitrust's antiquation. At one time, scholars predicted that fintechs could democratize banking while providing a critical source of competition. But then banks began to acquire their digital rivals: about 900 acquisitions of fintechs have taken place since 2021.
Gregory Day, Lindsay Sain Jones
wiley   +1 more source

Ribcage Morphology in Native South American Populations From Different Altitudes: Insights From a Global Comparative Framework

American Journal of Human Biology, Volume 38, Issue 2, February 2026.
ABSTRACT Objectives Altitude shapes human morphology as highland populations must cope with cold and hypoxic environments. Although Andean highlanders have been proposed to exhibit larger and deeper ribcages, this idea is mainly based on research using disarticulated skeletal elements or non‐South American controls. The objective of this research is to
J. M. López‐Rey, M. D. D’Angelo del Campo, G. Bettera Marcat, M. Arrieta, M. Fabra, S. Salega, P. Mercolli, V. Seldes, D. García‐Martínez, M. Bastir   +9 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source