Results 11 to 20 of about 124,650 (163)

Preclinical In Vitro Studies with 3D Spheroids to Evaluate Cu(DDC)₂ Containing Liposomes for the Treatment of Neuroblastoma. [PDF]

Pharmaceutics, 2021
Preclinical in vitro studies of drug candidates for anticancer therapy are generally conducted on well-established 2D cell models. Unfortunately, these models are unable to mimic the properties of in vivo tumors.
Hartwig F, Köll-Weber M, Süss R.
europepmc   +2 more sources

Development of In Vitro Parkinson's Disease Model Mediated by MPP+ and α-Synuclein Using Wharton's Jelly Mesenchymal Stem Cells. [PDF]

CNS Neurosci Ther
A cost‐effective and rapid in vitro model of Parkinson's disease was created using Wharton's Jelly‐derived mesenchymal stem cells by employing MPP+ iodide or A53T mutated α‐synuclein. ABSTRACT Main Problem The mechanism behind Parkinson's disease (PD) is still unclear, and a cure to stop its progression is yet to be found.
Gamit N, Patil M, Soumya BS, Dharmarajan A, Warrier S.   +4 more
europepmc   +2 more sources

Cost analysis of intrauterine balloon tamponade versus uterine artery embolization in the management of persistent postpartum hemorrhage. [PDF]

Int J Gynaecol Obstet
Abstract Objective The aim of this study was to compare the cost of a strategy initially resorting to intrauterine balloon tamponade versus a strategy initially resorting to uterine artery embolization in the management pathway of persistent postpartum hemorrhage.
Bonsen LR, van den Akker-van Marle ME, Caram-Deelder C, Ramler PI, de Groot CJM, Urlings T, van den Akker T, van der Bom JG, Henriquez DDCA, TeMpOH‐1 study group.   +9 more
europepmc   +2 more sources

Prevalence of DDC genotypes in patients with aromatic L-amino acid decarboxylase (AADC) deficiency and in silico prediction of structural protein changes.

Molecular Genetics and Metabolism, 2023
Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare autosomal recessive genetic disorder affecting the biosynthesis of dopamine, a precursor of both norepinephrine and epinephrine, and serotonin.
N. Himmelreich, M. Bertoldi, M. Alfadhel, M. Alghamdi, Y. Anikster, X. Bao, Fahad A. Bashiri, B. B. Zeev, Giovanni Bisello, A. Ceylan, Y. Chien, Y. Choy, S. Elsea, Lisa Flint, À. García-Cazorla, C. Gijavanekar, Emel Gümüş, M. Hamad, B. Hismi, T. Honzík, Oya Kuseyri Hübschmann, W. Hwu, Salvador Ibáñez-Micó, K. Jeltsch, N. Juliá-Palacios, C. Kasapkara, M. Kurian, K. Kuśmierska, Ning Liu, L. Ngu, John D. Odom, W. Ong, T. Opladen, Mari Oppebøen, Phillip L. Pearl, Belén Pérez, Roser Pons, A. Rygiel, Tan Ee Shien, R. Spaull, J. Sykut‐Cegielska, B. Tabarki, Trine Tangeraas, B. Thöny, T. Wassenberg, Y. Wen, Y. Yakob, J. G. Yin, J. Zeman, N. Blau   +49 more
semanticscholar   +1 more source

Tissue-specific Grb10/Ddc insulator drives allelic architecture for cardiac development

Molecules and Cells, 2022
Allele-specific expression of imprinted gene clusters is governed by gametic DNA methylation at master regulators called imprinting control regions (ICRs).
Aimee M. Juan, Yee Hoon Foong, J. L. Thorvaldsen, Y. Lan, N. Leu, J. Rurik, Li Li, Christopher J. Krapp, Casey L Rosier, J. Epstein, M. Bartolomei   +10 more
semanticscholar   +1 more source

Neurotransmitters and Immunity: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets. [PDF]

MedComm (2020)
Role of neurotransmitters in multiple pathological processes. Various neurotransmitters, including ACh, EPI, NE, 5‐HT, histamine, DA, glutamate, GABA, and neuropeptides participate in regulating key pathological events, including tumor proliferation, tumor migration, remodeling of the immune microenvironment, and the development of NDDs and ...
Li G, Li F, Tang Y, Guo S, Yao Y, Fang Y, Zhang B, Jiang Y, Wang J, Wu D, Cheng J, Huang Z, Xin Z, Zhang T.   +13 more
europepmc   +2 more sources

Spectrum of DDC variants causing aromatic l-amino acid decarboxylase (AADC) deficiency and pathogenicity interpretation using ACMG-AMP/ACGS recommendations.

Molecular Genetics and Metabolism, 2022
Pathogenic variants in dopa decarboxylase (DDC), the gene encoding the aromatic l-amino acid decarboxylase (AADC) enzyme, lead to a severe deficiency of neurotransmitters, resulting in neurological, neuromuscular, and behavioral manifestations clinically
N. Himmelreich, R. Montioli, S. Garbade, J. Kopesky, S. Elsea, C. Carducci, C. Voltattorni, N. Blau   +7 more
semanticscholar   +1 more source

Melanin Synthesis Pathway Interruption: CRISPR/Cas9-mediated Knockout of dopa decarboxylase (DDC) in Harmonia axyridis (Coleoptera: Coccinellidae)

Journal of Insect Science, 2022
CRISPR/Cas9 technology is a very powerful genome editing tool and has been used in many insect species for functional genomics studies through targeted gene mutagenesis.
Meng-meng Wu, Xu Chen, Qingbiao Xu, L. Zang, Su Wang, Ming Li, D. Xiao   +6 more
semanticscholar   +1 more source

A pairwise distance distribution correction (DDC) algorithm to eliminate blinking-caused artifacts in SMLM

Nature Methods, 2021
Single-molecule localization microscopy (SMLM) relies on the blinking behavior of a fluorophore, which is the stochastic switching between fluorescent and dark states. Blinking creates multiple localizations belonging to the same fluorophore, confounding
C. Bohrer, Xinxing Yang, Shreyasi Thakur, Xiaoli Weng, Brian Tenner, Ryan J. McQuillen, Brian L. Ross, Matthew Wooten, Xin Chen, Jin Zhang, Elijah Roberts, M. Lakadamyali, Jie Xiao   +12 more
semanticscholar   +1 more source

In Arabidopsis thaliana Cd differentially impacts on hormone genetic pathways in the methylation defective ddc mutant compared to wild type

Scientific Reports, 2021
DNA methylation plays an important role in modulating plant growth plasticity in response to stress, but mechanisms involved in such control need further investigation.
M. Pacenza, A. Muto, A. Chiappetta, L. Mariotti, E. Talarico, P. Picciarelli, E. Picardi, L. Bruno, M. B. Bitonti   +8 more
semanticscholar   +1 more source