Results 11 to 20 of about 74,147 (114)

Development of In Vitro Parkinson's Disease Model Mediated by MPP+ and α-Synuclein Using Wharton's Jelly Mesenchymal Stem Cells. [PDF]

CNS Neurosci Ther
A cost‐effective and rapid in vitro model of Parkinson's disease was created using Wharton's Jelly‐derived mesenchymal stem cells by employing MPP+ iodide or A53T mutated α‐synuclein. ABSTRACT Main Problem The mechanism behind Parkinson's disease (PD) is still unclear, and a cure to stop its progression is yet to be found.
Gamit N, Patil M, Soumya BS, Dharmarajan A, Warrier S.   +4 more
europepmc   +2 more sources

Neurotransmitters and Immunity: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets. [PDF]

MedComm (2020)
Role of neurotransmitters in multiple pathological processes. Various neurotransmitters, including ACh, EPI, NE, 5‐HT, histamine, DA, glutamate, GABA, and neuropeptides participate in regulating key pathological events, including tumor proliferation, tumor migration, remodeling of the immune microenvironment, and the development of NDDs and ...
Li G, Li F, Tang Y, Guo S, Yao Y, Fang Y, Zhang B, Jiang Y, Wang J, Wu D, Cheng J, Huang Z, Xin Z, Zhang T.   +13 more
europepmc   +2 more sources

Improved telangiectasia and reduced recurrence rate of rosacea after treatment with 540 nm-wavelength intense pulsed light: A prospective randomized controlled trial with a 2-year follow-up

Experimental and Therapeutic Medicine, 2020
The aim of the present study was to evaluate the clinical efficacy and safety of 540 nm-wavelength intense pulsed light (IPL) for the treatment of telangiectasia in late-stage rosacea.
Yang Luo, X. Luan, Jianhong Zhang, Lan-Xi Wu, Nan Zhou   +4 more
semanticscholar   +1 more source

L-Dopa-Decarboxylase (DDC) Is a Positive Prognosticator for Breast Cancer Patients and Epinephrine Regulates Breast Cancer Cell (MCF7 and T47D) Growth In Vitro According to Their Different Expression of Gi- Protein- Coupled Receptors

International Journal of Molecular Sciences, 2020
A coherence between thyroid dysfunction and breast cancer incidence exists. Thyroid hormone metabolites bind to TAAR1 (trace amine-associated receptor 1) and through that modulate the serotonergic and dopaminergic system.
E. Tremmel, C. Kuhn, T. Kaltofen, T. Vilsmaier, D. Mayr, S. Mahner, N. Ditsch, U. Jeschke, A. Vattai   +8 more
semanticscholar   +1 more source

Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson’s disease

Acta Neuropathologica
Parkinson’s disease (PD) starts at the molecular and cellular level long before motor symptoms appear, yet there are no early-stage molecular biomarkers for diagnosis, prognosis prediction, or monitoring therapeutic response.
J. Rutledge, B. Lehallier, Pardis Zarifkar, P. M. Losada, M. Shahid-Besanti, D. Western, P. Gorijala, S. Ryman, M. Yutsis, Gayle K. Deutsch, Elizabeth C. Mormino, A. Trelle, Anthony D. Wagner, G. Kerchner, Lu Tian, C. Cruchaga, V. Henderson, T. Montine, P. Borghammer, Tony Wyss-Coray, K. Poston   +20 more
semanticscholar   +1 more source

Red (660 nm) or near-infrared (810 nm) photobiomodulation stimulates, while blue (415 nm), green (540 nm) light inhibits proliferation in human adipose-derived stem cells

Scientific Reports, 2017
We previously showed that blue (415 nm) and green (540 nm) wavelengths were more effective in stimulating osteoblast differentiation of human adipose-derived stem cells (hASC), compared to red (660 nm) and near-infrared (NIR, 810 nm).
Yuguang Wang, Ying-ying Huang, Yong Wang, P. Lyu, Michael R Hamblin   +4 more
semanticscholar   +1 more source

Nrf2 Ameliorates DDC-Induced Sclerosing Cholangitis and Biliary Fibrosis and Improves the Regenerative Capacity of the Liver.

Toxicological Sciences, 2019
The Nrf2 pathway protects against oxidative stress and induces regeneration of various tissues. Here, we investigated whether Nrf2 protects from sclerosing cholangitis and biliary fibrosis and simultaneously induces liver regeneration.
A. Fragoulis, J. Schenkel, M. Herzog, Tim Schellenberg, H. Jahr, T. Pufe, C. Trautwein, T. Kensler, K. Streetz, C. Wruck   +9 more
semanticscholar   +1 more source

Diving Deeper Into Mechanisms of Acrylamide‐Induced Toxicity: RNA Sequencing Reveals Transcriptomic Alteration and Retrotransposon Expression in Drosophila melanogaster

Environmental Toxicology, EarlyView.
ABSTRACT Given the inevitability of human and animal exposure to acrylamide, there is increasing concern regarding its potential health risks. While a number of molecular mechanisms have been proposed, the complexity of acrylamide toxicological pathways and interactions remains incompletely characterized.
Oluwabukola Mary Farodoye, Titilayomi Ayomide Otenaike, Daniela Moreira Mombach, Monica Medeiros Silva, Amos Olalekan Abolaji, Elgion Lucio Da Silva Loreto   +5 more
wiley   +1 more source

Antitrust for the fintech era

American Business Law Journal, Volume 63, Issue 1, Page 57-78, Spring 2026.
Abstract The emerging relationship between fintechs and banks has revealed antitrust's antiquation. At one time, scholars predicted that fintechs could democratize banking while providing a critical source of competition. But then banks began to acquire their digital rivals: about 900 acquisitions of fintechs have taken place since 2021.
Gregory Day, Lindsay Sain Jones
wiley   +1 more source

Analysis of Expression and Functional Activity of Aromatic L-Amino Acid Decarboxylase (DDC) and Serotonin Transporter (SERT) as Potential Sources of Serotonin in Mouse Ovary

International Journal of Molecular Sciences, 2019
The origin of serotonin in the ovary is the key question for understanding mechanisms of serotonergic regulation of reproductive function. We performed a study of the expression and functional activity of the serotonin transporter (SERT) and the enzyme ...
D. A. Nikishin, N. M. Alyoshina, M. Semenova, Y. B. Shmukler   +3 more
semanticscholar   +1 more source