Results 1 to 10 of about 54,918 (114)

Melanin Synthesis Pathway Interruption: CRISPR/Cas9-mediated Knockout of dopa decarboxylase (DDC) in Harmonia axyridis (Coleoptera: Coccinellidae). [PDF]

J Insect Sci, 2022
CRISPR/Cas9 technology is a very powerful genome editing tool and has been used in many insect species for functional genomics studies through targeted gene mutagenesis.
Wu MM, Chen X, Xu QX, Zang LS, Wang S, Li M, Xiao D.   +6 more
europepmc   +2 more sources

Accuracy and interpretability of smartwatch electrocardiogram for early detection of atrial fibrillation: A systematic review and meta-analysis. [PDF]

J Arrhythm
The smartwatch ECG algorithm achieved 86% sensitivity and 94% specificity with an sAUC of 96%, while manual readings by trained personnel reached 96% sensitivity, 95% specificity, and an sAUC of 98% in a brand‐specific subgroup analysis. These findings demonstrate that the smartwatch ECG detects AFib, although 3% of results are unreadable.
Iqhrammullah M, Abdullah A, Hermansyah, Ichwansyah F, Rani HA, Alina M, Simanjuntak AMT, Rampengan DDCH, Al-Gunaid ST, Gusti N, Damarkusuma A, Wikurendra EA.   +11 more
europepmc   +2 more sources

Prevalence of DDC genotypes in patients with aromatic L-amino acid decarboxylase (AADC) deficiency and in silico prediction of structural protein changes.

Molecular Genetics and Metabolism, 2023
Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare autosomal recessive genetic disorder affecting the biosynthesis of dopamine, a precursor of both norepinephrine and epinephrine, and serotonin.
N. Himmelreich, M. Bertoldi, M. Alfadhel, M. Alghamdi, Y. Anikster, X. Bao, Fahad A. Bashiri, B. B. Zeev, Giovanni Bisello, A. Ceylan, Y. Chien, Y. Choy, S. Elsea, Lisa Flint, À. García-Cazorla, C. Gijavanekar, Emel Gümüş, M. Hamad, B. Hismi, T. Honzík, Oya Kuseyri Hübschmann, W. Hwu, Salvador Ibáñez-Micó, K. Jeltsch, N. Juliá-Palacios, C. Kasapkara, M. Kurian, K. Kuśmierska, Ning Liu, L. Ngu, John D. Odom, W. Ong, T. Opladen, Mari Oppebøen, P. Pearl, Belén Pérez, Roser Pons, A. Rygiel, Tan Ee Shien, R. Spaull, J. Sykut-Cegielska, B. Tabarki, Trine Tangeraas, B. Thöny, T. Wassenberg, Y. Wen, Y. Yakob, J. G. Yin, J. Zeman, N. Blau   +49 more
semanticscholar   +1 more source

Comparative analysis of genome-scale, base-resolution DNA methylation profiles across 580 animal species

bioRxiv, 2022
Methylation of cytosines is a prototypic epigenetic modification of the DNA. It has been implicated in various regulatory mechanisms across the animal kingdom and particularly in vertebrates.
J. Klughammer, Daria Romanovskaia, A. Nemc, A. Posautz, C. Seid, L. Schuster, Melissa C. Keinath, J. S. Lugo Ramos, Lindsay Kosack, Ann Evankow, D. Printz, Stefanie Kirchberger, B. Ergüner, Paul Datlinger, N. Fortelny, Christian Schmidl, M. Farlik, K. Skjærven, A. Bergthaler, Miriam Liedvogel, Denise Thaller, P. Burger, Marcela Hermann, M. Distel, D. Distel, A. Kübber-Heiss, Christoph Bock   +26 more
semanticscholar   +1 more source

Tissue-specific Grb10/Ddc insulator drives allelic architecture for cardiac development.

Molecules and Cells, 2022
Allele-specific expression of imprinted gene clusters is governed by gametic DNA methylation at master regulators called imprinting control regions (ICRs).
Aimee M. Juan, Yee Hoon Foong, J. L. Thorvaldsen, Y. Lan, N. Leu, Joel G. Rurik, Li Li, Christopher J. Krapp, Casey L Rosier, J. Epstein, M. Bartolomei   +10 more
semanticscholar   +1 more source

Spectrum of DDC variants causing aromatic l-amino acid decarboxylase (AADC) deficiency and pathogenicity interpretation using ACMG-AMP/ACGS recommendations.

Molecular Genetics and Metabolism, 2022
Pathogenic variants in dopa decarboxylase (DDC), the gene encoding the aromatic l-amino acid decarboxylase (AADC) enzyme, lead to a severe deficiency of neurotransmitters, resulting in neurological, neuromuscular, and behavioral manifestations clinically
N. Himmelreich, R. Montioli, S. Garbade, Jeffrey W. Kopesky, S. Elsea, C. Carducci, C. Voltattorni, N. Blau   +7 more
semanticscholar   +1 more source

Carcinoma-associated fibroblasts derived exosomes modulate breast cancer cell stemness through exonic circHIF1A by miR-580-5p in hypoxic stress

Cell Death Discovery, 2021
Hypoxia is a common phenomenon in solid tumors. The roles of exosomes from hypoxic breast cancer stroma are less studied. So, the study was aimed to investigate the role of exosomes from hypoxic cancer-associated fibroblasts (CAFs) cells in breast cancer.
Yan-xia Zhan, Jun-Ze Du, Z. Min, Li Ma, Wei Zhang, Wei Zhu, Yonglei Liu   +6 more
semanticscholar   +1 more source

In Arabidopsis thaliana Cd differentially impacts on hormone genetic pathways in the methylation defective ddc mutant compared to wild type

Scientific Reports, 2021
DNA methylation plays an important role in modulating plant growth plasticity in response to stress, but mechanisms involved in such control need further investigation.
M. Pacenza, A. Muto, A. Chiappetta, L. Mariotti, E. Talarico, P. Picciarelli, E. Picardi, L. Bruno, M. B. Bitonti   +8 more
semanticscholar   +1 more source

Preclinical In Vitro Studies with 3D Spheroids to Evaluate Cu(DDC)2 Containing Liposomes for the Treatment of Neuroblastoma

Pharmaceutics, 2021
Preclinical in vitro studies of drug candidates for anticancer therapy are generally conducted on well-established 2D cell models. Unfortunately, these models are unable to mimic the properties of in vivo tumors.
F. Hartwig, M. Köll-Weber, R. Süss
semanticscholar   +1 more source

CircRNA hsa_circ_0110102 inhibited macrophage activation and hepatocellular carcinoma progression via miR-580-5p/PPARα/CCL2 pathway

Aging, 2021
Circular RNAs (circRNAs) have critical regulatory roles in tumor biology. However, their contributions in hepatocellular carcinoma (HCC) still remain enigmatic. The present study aimed to investigate the molecular mechanisms underlying the involvement of
Xinxing Wang, W. Sheng, Tao Xu, Jiawen Xu, Ru-Xin Gao, Zhenhai Zhang   +5 more
semanticscholar   +1 more source