Results 1 to 10 of about 38,865 (96)

Melanin Synthesis Pathway Interruption: CRISPR/Cas9-mediated Knockout of dopa decarboxylase (DDC) in Harmonia axyridis (Coleoptera: Coccinellidae)

Journal of Insect Science, 2022
CRISPR/Cas9 technology is a very powerful genome editing tool and has been used in many insect species for functional genomics studies through targeted gene mutagenesis.
Meng-meng Wu, Xu Chen, Qingbiao Xu, L. Zang, Su Wang, Ming Li, D. Xiao   +6 more
semanticscholar   +1 more source

590 nm LED Irradiation Improved Erythema through Inhibiting Angiogenesis of Human Microvascular Endothelial Cells and Ameliorated Pigmentation in Melasma

Cells, 2022
Melasma is a common refractory acquired pigmentary skin disease that mainly affects middle-aged women. The pathogenesis of melasma is still uncertain, while abnormal vascular endothelial cells may play a role.
Xiaoxi Dai, Shanglin Jin, Y. Xuan, Yiwen Yang, Xiaoli Lu, Chen Wang, Li Chen, L. Xiang, Chengfeng Zhang   +8 more
semanticscholar   +1 more source

First-line pembrolizumab + chemotherapy in Japanese patients with advanced/metastatic esophageal cancer from KEYNOTE-590

Esophagus, 2022
The phase 3 KEYNOTE-590 (NCT03189719) study showed first-line pembrolizumab plus chemotherapy significantly prolonged overall survival and progression-free survival versus placebo plus chemotherapy in patients with advanced unresectable or metastatic ...
T. Kojima, H. Hara, A. Tsuji, H. Yasui, K. Muro, T. Satoh, T. Ogata, R. Ishihara, M. Goto, Hideo Baba, T. Nishina, S. Han, Tomoko Sakata, Naoyoshi Yatsuzuka, T. Doi, Ken Kato   +15 more
semanticscholar   +1 more source

In Arabidopsis thaliana Cd differentially impacts on hormone genetic pathways in the methylation defective ddc mutant compared to wild type

Scientific Reports, 2021
DNA methylation plays an important role in modulating plant growth plasticity in response to stress, but mechanisms involved in such control need further investigation.
M. Pacenza, A. Muto, A. Chiappetta, L. Mariotti, E. Talarico, P. Picciarelli, E. Picardi, L. Bruno, M. B. Bitonti   +8 more
semanticscholar   +1 more source

Exosomal miR-590-5p in Serum as a Biomarker for the Diagnosis and Prognosis of Gastric Cancer

Frontiers in Molecular Biosciences, 2021
The purpose of this study is to explore the expression of miRNA-590-5p, an exosome of gastric cancer (GC), and to evaluate the suitability of miR-590-5p, an exosome with its own clinical characteristics. Serum samples from 168 gastric cancer patients and
Guodian Zheng, Zhiyuan Xu, Can Hu, Hang Lv, Hua-Xia Xie, Ting Huang, Yanqiang Zhang, Gui-Ping Chen, Yu Fu, Xiang-dong Cheng   +9 more
semanticscholar   +1 more source

Preclinical In Vitro Studies with 3D Spheroids to Evaluate Cu(DDC)2 Containing Liposomes for the Treatment of Neuroblastoma

Pharmaceutics, 2021
Preclinical in vitro studies of drug candidates for anticancer therapy are generally conducted on well-established 2D cell models. Unfortunately, these models are unable to mimic the properties of in vivo tumors.
F. Hartwig, Monika Köll-Weber, R. Süss
semanticscholar   +1 more source

lncRNA SNHG4 modulates colorectal cancer cell cycle and cell proliferation through regulating miR-590-3p/CDK1 axis

Aging, 2021
Colorectal cancer (CRC) is a prevalent malignancy worldwide. The development of genome sequencing technology has allowed the discovery that epigenetic regulation might play a critical role in CRC tumorigenesis.
Zhongyi Zhou, Fengbo Tan, Q. Pei, Chenglong Li, Yuanquan Zhou, Yuqiang Li, Haiping Pei   +6 more
semanticscholar   +1 more source

Exosomal transfer of microRNA-590-3p between renal tubular epithelial cells after renal ischemia-reperfusion injury regulates autophagy by targeting TRAF6

Chinese Medical Journal, 2022
Background: Acute kidney injury (AKI) is a common complication in patients, especially elderly patients, who undergo cardiac surgery with cardiopulmonary bypass. Studies have indicated a protective role of autophagy in AKI.
Yimeng Chen, Congya Zhang, Yingjie Du, Xiying Yang, Min Liu, W. Yang, G. Lei, Guyan Wang   +7 more
semanticscholar   +1 more source

CircPUM1 promotes cell growth and glycolysis in NSCLC via up-regulating METTL3 expression through miR-590-5p

Cell Cycle, 2021
RNA pumilio RNA binding family member 1 (circPUM1) has been reported to play important roles in the tumorigenesis of several cancers. However, the underlying molecular role of circPUM1 in non-small cell lung cancer (NSCLC) progression remains unknown ...
Mingjun Li, Qian-Qian Wang, Xiaofei Zhang, N. Yan, Xingya Li   +4 more
semanticscholar   +1 more source

MicroRNA‐590‐3p inhibits T helper 17 cells and ameliorates inflammation in lupus mice

Immunology, 2021
T helper 17 (Th17) cells have a pathogenic effect in many autoimmune diseases. Inhibition of Th17 cells can alleviate the inflammatory damage in autoimmune diseases.
Jun-jun Huang, Xinzhi Xu, Xiuyuan Wang, Jie Yang, Meijuan Xue, Yiming Yang, Ruomei Zhang, Xue Yang, Ji Yang   +8 more
semanticscholar   +1 more source