Results 11 to 20 of about 38,884 (111)

The CRISPR-Cas9 knockout DDC SH-SY5Y in vitro model for AADC deficiency provides insight into the pathogenicity of R347Q and L353P variants: a cross-sectional structural and functional analysis. [PDF]

FEBS J
Here, we generated a DDC‐KO cellular model for studying aromatic amino acid decarboxylase (AADC) deficiency. This model was created using CRISPR‐Cas9 in the SH‐SY5Y neuroblastoma cell line and was validated through the absence of the dopamine product and an altered l‐dopa metabolite profile.
Carmona-Carmona CA, Bisello G, Franchini R, Lunardi G, Galavotti R, Perduca M, Ribeiro RP, Belviso BD, Giorgetti A, Caliandro R, Lievens PM, Bertoldi M.   +11 more
europepmc   +2 more sources

Neurotransmitters and Immunity: Molecular Mechanisms, Biological Functions, Diseases, and Potential Therapeutic Targets. [PDF]

MedComm (2020)
Role of neurotransmitters in multiple pathological processes. Various neurotransmitters, including ACh, EPI, NE, 5‐HT, histamine, DA, glutamate, GABA, and neuropeptides participate in regulating key pathological events, including tumor proliferation, tumor migration, remodeling of the immune microenvironment, and the development of NDDs and ...
Li G, Li F, Tang Y, Guo S, Yao Y, Fang Y, Zhang B, Jiang Y, Wang J, Wu D, Cheng J, Huang Z, Xin Z, Zhang T.   +13 more
europepmc   +2 more sources

Lauric acid with or without levodopa ameliorates Parkinsonism in genetically modified model of Drosophila melanogaster via the oxidative-inflammatory-apoptotic pathway. [PDF]

Brain Behav
Lauric acid exhibits therapeutic potential in alpha‐synuclein‐mediated Parkinsonism by mitigating behavioral impairment, reducing oxidative stress, and curbing neuroinflammation. It also appears to counteract apoptosis and enhance neuronal longevity. These effects collectively suggest lauric acid could be a promising adjunctive treatment for Parkinson ...
Idowu OK, Dosumu OO, Boboye AS, Oremosu AA, Mohammed AA.   +4 more
europepmc   +2 more sources

Liquid Crystalline Hydroxyapatite Nanorods Orchestrate Hierarchical Bone-Like Mineralization. [PDF]

Small
Unidirectional liquid crystalline hydroxyapatite nanorods guide the growth and osteogenesis of stem cells and the formation of ordered extracellular matrix and calcium deposits at multi‐scales. The PI3k‐Akt signaling pathway mediated by two key genes COL1A1 and COL4A6 is activated in this process.
Chen J, Birchall M, MacRobert AJ, Song W.   +3 more
europepmc   +2 more sources

Prodromal Parkinson's disease and the catecholaldehyde hypothesis: Insight from olfactory bulb organotypic cultures

The FASEB Journal, Volume 37, Issue 12, December 2023., 2023
Olfactory dysfunction is one of the most prevalent symptoms of Parkinson's disease preceding clinical onset by up to a decade. However, PD models focus mainly on motor symptoms and nigrostriatal degeneration. Here, we characterize cultured olfactory bulb organotypic slices and cells and explore the effect of DOPAL, a metabolite of dopamine.
Enrico Bagnoli, Alexandre Trotier, Jill McMahon, Leo R. Quinlan, Manus Biggs, Abhay Pandit, Una FitzGerald   +6 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2023/24: Enzymes

British Journal of Pharmacology, Volume 180, Issue S2, Page S289-S373, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jurg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +28 more
wiley   +1 more source

Rutin attenuates Sorafenib-induced Chemoresistance and Autophagy in Hepatocellular Carcinoma by regulating BANCR/miRNA-590-5P/OLR1 Axis

International Journal on Biological Sciences, 2021
Rutin, the main component of Potentilla discolor Bunge, was proven to exhibit anti-tumor properties. Sorafenib (SO) is conventionally used in chemotherapy against hepatocellular carcinoma (HCC), but acquired resistance developed during long-term therapy ...
Meng Zhou, Gan Zhang, Jun Hu, Yanzhi Zhu, Hao-Chang Lan, Xian-Feng Shen, Yi Lv, Linsheng Huang   +7 more
semanticscholar   +1 more source

Long non-coding RNA FAM225A promotes nasopharyngeal carcinoma tumorigenesis and metastasis by acting as ceRNA to sponge miR-590-3p/miR-1275 and upregulate ITGB3.

Cancer Research, 2019
Long non-coding RNAs (lncRNAs) play important roles in the tumorigenesis and progression of cancers. However, the clinical significance of lncRNAs and their regulatory mechanisms in nasopharyngeal carcinogenesis (NPC) are largely unknown.
Zi-Qi Zheng, Zhi-Xuan Li, G. Zhou, Li Lin, Lulu Zhang, J. Lv, Xiao-Dan Huang, Rui-Qi Liu, Fo-Ping Chen, Xiao-Jun He, J. Kou, J. Zhang, Xin Wen, Yingqin Li, Jun Ma, Na Liu, Ying Sun   +16 more
semanticscholar   +1 more source

Circ_0124644 Serves as a ceRNA for miR-590-3p to Promote Hypoxia-Induced Cardiomyocytes Injury via Regulating SOX4

Frontiers in Genetics, 2021
Circular RNA (circRNA) is an important factor for regulating the progression of many cardiovascular diseases, including acute myocardial infarction (AMI). However, the role of circ_0124644 in AMI progression remains unclear.
Juan Tan, Weinan Pan, Huilin Chen, Yafang Du, P. Jiang, Dianmei Zeng, Jie Wu, Kuang Peng   +7 more
semanticscholar   +1 more source

Circulating microRNA‐590‐5p functions as a liquid biopsy marker in non‐small cell lung cancer

Cancer Science, 2020
Despite the availability of various diagnostic procedures, a tissue biopsy is still indispensable for the routine diagnosis of lung cancer. However, inaccurate diagnoses can occur, leading to inefficient cancer management.
Akanksha Khandelwal, R. Seam, M. Gupta, M. Rana, H. Prakash, K. Vasquez, Aklank Jain   +6 more
semanticscholar   +1 more source