Results 91 to 100 of about 48,357 (114)

Automatically pre-screening patients for the rare disease aromatic l-amino acid decarboxylase deficiency using knowledge engineering, natural language processing, and machine learning on a large EHR population. [PDF]

J Am Med Inform Assoc
Cohen AM, Kaner J, Miller R, Kopesky JW, Hersh W.   +4 more
europepmc   +1 more source

Protecting the confidentiality of interim data: addressing current challenges. [PDF]

Clin Trials, 2015
Fleming TR.
europepmc   +1 more source

Leveraging increased cytoplasmic nucleoside kinase activity to target mtDNA and oxidative phosphorylation in AML.

Blood, 2017
Liyanage SU, Hurren R, Voisin V, Bridon G, Wang X, Xu C, MacLean N, Siriwardena TP, Gronda M, Yehudai D, Sriskanthadevan S, Avizonis D, Shamas-Din A, Minden MD, Bader GD, Laposa R, Schimmer AD.   +16 more
europepmc   +1 more source

Sex-based differences in short- and longer-term diet-induced metabolic heart disease.

Am J Physiol Heart Circ Physiol
Croft AJ, Kelly C, Chen D, Haw TJ, Balachandran L, Murtha LA, Boyle AJ, Sverdlov AL, Ngo DTM.   +8 more
europepmc   +1 more source

Chronic lysosome damage boosts interferon responses to Palbociclib dependent upon the mitochondrion

Bozic M, Lim TE, Salomó-Coll C, Karageorgiou A, Kemp AJ, Winnington-Ingram K, Murphy L, Dhir A, Wheeler A, Jimenez-Moreno N, Wilkinson S.   +10 more
europepmc   +1 more source

Multimodal decoding of human liver regeneration. [PDF]

Nature
Matchett KP, Wilson-Kanamori JR, Portman JR, Kapourani CA, Fercoq F, May S, Zajdel E, Beltran M, Sutherland EF, Mackey JBG, Brice M, Wilson GC, Wallace SJ, Kitto L, Younger NT, Dobie R, Mole DJ, Oniscu GC, Wigmore SJ, Ramachandran P, Vallejos CA, Carragher NO, Saeidinejad MM, Quaglia A, Jalan R, Simpson KJ, Kendall TJ, Rule JA, Lee WM, Hoare M, Weston CJ, Marioni JC, Teichmann SA, Bird TG, Carlin LM, Henderson NC.   +35 more
europepmc   +1 more source

A Novel POR G88S Mutation Causes Severe PORD and Establishes a Critical Pharmacogenomic Risk Profile.

J Clin Endocrinol Metab
Rojas Velazquez MN, Lopez Dacal J, Jørgensen FS, Sanguineti N, Sharma K, Marino R, Pérez Garrido N, Vaiani E, Ramírez P, Scaglia P, Izquierdo A, Sansó G, Ropelato MG, Bergadá I, Rey RA, Grinspon RP, Pandey AV.   +16 more
europepmc   +1 more source

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Sphingomyelin-based PEGylation Cu(DDC)2 Liposomes Prepared via the Dual Function of Cu2+ for Cancer Therapy: Facilitating DDC Loading and Exerting Synergistic Antitumor Effects.

International journal of pharmaceutics, 2022
The old alcohol-aversion drug disulfiram (DSF) has aroused wide attention as a drug repurposing strategy in terms of cancer therapy because of the high antitumor efficacy in combination with copper ion.
Hao Liu, Yihan Kong, Zixu Liu, Xue-Ting Guo, Binghua Yang, Tian Yin, Hai-Bing He, Jing-Xin Gou, Yu Zhang, Xing Tang   +9 more
semanticscholar   +1 more source

Epigenetic mechanisms affect the curled leaf phenotype in the hypomethylated ddc mutant of Arabidopsis thaliana.

Plant Science, 2022
The ddc mutant of Arabidopsis thaliana is characterized by pleiotropic phenotypic alterations including a curl-shaped leaf, previously explained by disturbed auxin metabolism and transport.
Ivano Forgione, A. Muto, M. Wołoszyńska, A. Chiappetta, M. Ferrari, M. Van Lijsebettens, M. B. Bitonti, L. Bruno   +7 more
semanticscholar   +1 more source

Geniposide suppresses liver injury in a mouse model of DDC‐induced sclerosing cholangitis

Phytotherapy Research, 2021
Sclerosing cholangitis, characterized by biliary inflammation, fibrosis, and stricturing, remains one of the most challenging conditions of clinical hepatology. Geniposide (GE) has anti‐inflammatory, hepatoprotective, and cholagogic effects.
Min Wen, Yubei Liu, Ruiying Chen, P. He, Fei-Hua Wu, Rui Li, Yining Lin   +6 more
semanticscholar   +1 more source