Results 31 to 40 of about 48,026 (115)

Revised Exon Structure of l-DOPA Decarboxylase (DDC) Reveals Novel Splice Variants Associated with Colorectal Cancer Progression

open access: yesInternational Journal of Molecular Sciences, 2020
Colorectal cancer (CRC) is a highly heterogenous malignancy with an increased mortality rate. Aberrant splicing is a typical characteristic of CRC, and several studies support the prognostic value of particular transcripts in this malignancy.
P. Artemaki   +7 more
semanticscholar   +1 more source

Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson’s disease

open access: yesActa Neuropathologica
Parkinson’s disease (PD) starts at the molecular and cellular level long before motor symptoms appear, yet there are no early-stage molecular biomarkers for diagnosis, prognosis prediction, or monitoring therapeutic response.
J. Rutledge   +20 more
semanticscholar   +1 more source

Circular RNA MAT2B Induces Colorectal Cancer Proliferation via Sponging miR-610, Resulting in an Increased E2F1 Expression

open access: yesCancer Management and Research, 2020
Purpose Recently, studies have demonstrated that a novel circular RNA (circRNA), circMAT2B, can promote cell proliferation and can thus contribute to the growth and development of hepatocellular carcinoma.
Jian Zhao, Li Chen
semanticscholar   +1 more source

Nrf2 Ameliorates DDC-Induced Sclerosing Cholangitis and Biliary Fibrosis and Improves the Regenerative Capacity of the Liver.

open access: yesToxicological Sciences, 2019
The Nrf2 pathway protects against oxidative stress and induces regeneration of various tissues. Here, we investigated whether Nrf2 protects from sclerosing cholangitis and biliary fibrosis and simultaneously induces liver regeneration.
A. Fragoulis   +9 more
semanticscholar   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

open access: yesBritish Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander   +31 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

open access: yesBritish Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander   +28 more
wiley   +1 more source

UEG Week 2023 Moderated Posters

open access: yes, 2023
United European Gastroenterology Journal, Volume 11, Issue S8, Page 201-534, October 2023.
wiley   +1 more source

Analysis of Expression and Functional Activity of Aromatic L-Amino Acid Decarboxylase (DDC) and Serotonin Transporter (SERT) as Potential Sources of Serotonin in Mouse Ovary

open access: yesInternational Journal of Molecular Sciences, 2019
The origin of serotonin in the ovary is the key question for understanding mechanisms of serotonergic regulation of reproductive function. We performed a study of the expression and functional activity of the serotonin transporter (SERT) and the enzyme ...
D. A. Nikishin   +3 more
semanticscholar   +1 more source

Ferroptosis in Cancer and Inflammatory Diseases: Mechanisms and Therapeutic Implications

open access: yesMedComm, Volume 6, Issue 9, September 2025.
Ferroptosis, a form of cell death driven by iron and lipid peroxidation, serves as a bridge between cancer and inflammatory diseases. Microenvironmental factors such as oxidative stress collectively regulate this process. In cancer, ferroptosis exhibits dual roles: while it eliminates drug‐resistant cells, it may also promote tumor metastasis.
Guangyi Shen   +4 more
wiley   +1 more source

Heart failure in Europe: Guideline‐directed medical therapy use and decision making in chronic and acute, pre‐existing and de novo, heart failure with reduced, mildly reduced, and preserved ejection fraction – the ESC EORP Heart Failure III Registry

open access: yesEuropean Journal of Heart Failure, Volume 26, Issue 12, Page 2487-2501, December 2024.
The ESC Heart Failure III Registry enrolled 10 162 patients between 2018 and 2020, with acute heart failure (HF) and in the outpatient setting, with pre‐existing and de novo HF, in cardiology and non‐cardiology settings, including patients with HF with reduced (HFrEF), mildly reduced (HFmrEF) and preserved ejection fraction (HFpEF).
Lars H. Lund   +1226 more
wiley   +1 more source

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