Results 1 to 10 of about 330 (68)

Calcineurin Activation by Prion Protein Induces Neurotoxicity via Mitochondrial Reactive Oxygen Species. [PDF]

Oxid Med Cell Longev, 2021
Prion diseases are caused by PrPsc accumulation in the brain, which triggers dysfunctional mitochondrial injury and reactive oxygen species (ROS) generation in neurons. Recent studies on prion diseases suggest that endoplasmic reticulum (ER) stress induced by misfolding proteins such as misfolded prion protein results in activation of calcineurin ...
Moon JH, Hong JM, Park SY.
europepmc   +2 more sources

The Concise Guide to PHARMACOLOGY 2023/24: Enzymes

British Journal of Pharmacology, Volume 180, Issue S2, Page S289-S373, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jurg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +28 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2023/24: Transporters

British Journal of Pharmacology, Volume 180, Issue S2, Page S374-S469, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +27 more
wiley   +1 more source

Tryptophan Metabolism Acts as a New Anti‐Ferroptotic Pathway to Mediate Tumor Growth

Advanced Science, Volume 10, Issue 6, February 24, 2023., 2023
Tryptophan metabolites 5‐HT and 3‐HA act as potent radical trapping antioxidants to inhibit ferroptosis both in vitro and in vivo. Tryptophan metabolites‐mediated ferroptosis suppression is a new anti‐ferroptosis pathway distinct from cysteine‐mediated ferroptosis inhibition or any other classical anti‐ferroptotic pathways to facilitate tumor ...
Dong Liu, Chun‐hui Liang, Bin Huang, Xiao Zhuang, Weiwei Cui, Li Yang, Yinghong Yang, Yudan Zhang, Xiaolong Fu, Xiaoju Zhang, Lutao Du, Wei Gu, Xiangdong Wang, Chengqian Yin, Renjie Chai, Bo Chu   +15 more
wiley   +1 more source

Therapeutic Nanocarriers Inhibit Chemotherapy‐Induced Breast Cancer Metastasis

Advanced Science, Volume 9, Issue 33, November 24, 2022., 2022
Polymeric nanoparticles are developed, that deliver chemotherapeutics and scavenge damage‐associated molecular patterns simultaneously to inhibit chemotherapy‐induced breast cancer metastasis. The cationic nanoparticles can adsorb cell‐free nucleic acids based on charge–charge interaction, which downregulates the expression of Toll‐like receptors and ...
Tianyu Li, Tolulope Akinade, Jie Zhou, Hongxia Wang, Qisong Tong, Siyu He, Emily Rinebold, Luis E. Valencia Salazar, Divya Bhansali, Yiling Zhong, Jing Ruan, Jinzhi Du, Piero Dalerba, Kam W. Leong   +13 more
wiley   +1 more source

Incidence of hypertension in people with HIV who are treated with integrase inhibitors versus other antiretroviral regimens in the RESPOND cohort consortium

HIV Medicine, Volume 23, Issue 8, Page 895-910, September 2022., 2022
Abstract Objective To compare the incidence of hypertension in people living with HIV receiving integrase strand transfer inhibitor (INSTI)‐based antiretroviral therapy (ART) versus non‐nucleoside reverse transcriptase inhibitors (NNRTIs) or boosted protease inhibitors (PIs) in the RESPOND consortium of HIV cohorts.
Dathan M. Byonanebye, Mark N. Polizzotto, Bastian Neesgaard, Mario Sarcletti, Raimonda Matulionyte, Dominique L. Braun, Antonella Castagna, Stéphane de Wit, Ferdinand Wit, Eric Fontas, Jörg Janne Vehreschild, Jan Vesterbacka, Lauren Greenberg, Camilla Hatleberg, Harmony Garges, Joel Gallant, Alain Volny Anne, Angela Öllinger, Iwona Mozer‐Lisewska, Bernard Surial, Vincenzo Spagnuolo, Coca Necsoi, Marc van der Valk, Amanda Mocroft, Matthew Law, Lene Ryom, Kathy Petoumenos, the RESPOND study group, M Hillebregt, N Rose, J Hutchinson, R Zangerle, H Appoyer, M Delforge, C Stephan, M Bucht, N Chkhartishvili, O Chokoshvili, C Mussini, V Borghi, C Pradier, K Dollet, C Caissotti, J Casabona, JM Miro, C Smith, F Lampe, M Johnson, F Burns, C Chaloner, A Lazzarin, A Poli, A Sönnerborg, K Falconer, V Svedhem, H Günthard, B Ledergerber, H Bucher, A Scherrer, JC Wasmuth, J Rockstroh, G Fätkenheuer, M Stecher, N Schulze, B Franke, Lene Ryom, J Rooney, I McNicholl, V Vannappagari, G Wandeler, J Lundgren, J Kowalska, D Raben, A Mocroft, L Peters, ED Williams, C Necsoi, A D’Arminio Monforte, A Bruguera, Nikos Dedes, Luis Mendao, JF Larsen, N Jaschinski, ML Jakobsen, T Bruun, A Bojesen, EV Hansen, AK Traytel, TW Elsing, D Kristensen, T Weide, L Bansi‐Matharu, A Pelchen‐Matthews   +92 more
wiley   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes

British Journal of Pharmacology, Volume 178, Issue S1, Page S313-S411, October 2021., 2021
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander, Doriano Fabbro, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, Jamie A Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Doris Koesling, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Michael Russwurm, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +32 more
wiley   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters

British Journal of Pharmacology, Volume 178, Issue S1, Page S412-S513, October 2021., 2021
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander, Eamonn Kelly, Alistair Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Adam J Pawson, Christopher Southan, Jamie A Davies, Laura Amarosi, Catriona M. H. Anderson, Philip Mark Beart, Stefan Broer, Paul A. Dawson, Bruno Hagenbuch, James R. Hammond, Jules C Hancox, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Gavin Stewart, David T. Thwaites, Tiziano Verri   +24 more
wiley   +1 more source

The genomics of phenotypically differentiated Asellus aquaticus cave, surface stream and lake ecotypes

Molecular Ecology, Volume 30, Issue 14, Page 3530-3547, July 2021., 2021
Abstract Organisms well suited for the study of ecotype formation have wide distribution ranges, where they adapt to multiple drastically different habitats repeatedly over space and time. Here we study such ecotypes in a Crustacean model, Asellus aquaticus, a commonly occurring isopod found in freshwater habitats as diverse as streams, caves and lakes.
Vid Bakovic, Maria Luisa Martin Cerezo, Andrey Höglund, Jesper Fogelholm, Rie Henriksen, Anders Hargeby, Dominic Wright   +6 more
wiley   +1 more source

Burden of arrhythmia in hospitalized HIV patients

Clinical Cardiology, Volume 44, Issue 1, Page 66-77, January 2021., 2021
Abstract Background The improved life expectancy observed in patients living with human immunodeficiency virus (HIV) infection has made age‐related cardiovascular complications, including arrhythmias, a growing health concern. Hypothesis We describe the temporal trends in frequency of various arrhythmias and assess impact of arrhythmias on hospitalized
Anas A. Abudan, Vaibhav R. Vaidya, Byomesh Tripathi, Peter A. Noseworthy, Daniel C. DeSimone, Alexander Egbe, Shilpkumar Arora, Haarini Sridhar, Christopher V. DeSimone, Siva Mulpuru, Abhishek J. Deshmukh   +10 more
wiley   +1 more source