Results 31 to 40 of about 20,132 (109)

The Evolution of the Neural Basic Helix‐Loop‐Helix Proteins

open access: yesThe Scientific World Journal, Volume 1, Issue 2, Page 396-426, 2001., 2001
Basic Helix‐Loop‐Helix (bHLH) transcription factors control various aspects of the formation of the nervous system in the metazoans. In Drosophila some bHLH (such as the achaete‐scuteatonal, and amos genes) act as proneural genes, directing ectodermal cells toward a neural fate.
Michel Vervoort, Valerie Ledent
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Transporters

open access: yesBritish Journal of Pharmacology, Volume 182, Issue S1, Page S404-S496, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander   +28 more
wiley   +1 more source

USP38, FREM3, SDC1, DDC, and LOC727982 Gene Polymorphisms and Differential Susceptibility to Severe Malaria in Tanzania

open access: yesJournal of Infectious Diseases, 2015
Populations exposed to Plasmodium falciparum infection develop genetic mechanisms of protection against severe malarial disease. Despite decades of genetic epidemiological research, the sickle cell trait (HbAS) sickle cell polymorphism, ABO blood group ...
A. Manjurano   +10 more
semanticscholar   +1 more source

Multiple genetic variants at the SLC30A8 locus affect local super‐enhancer activity and influence pancreatic β‐cell survival and function

open access: yesThe FASEB Journal, Volume 38, Issue 8, 30 April 2024.
GWAS‐identified SLC30A8 locus contains an islet super‐enhancer cluster. This super‐enhancer cluster regulates the expression of not only the SLC30A8 gene but also multiple other genes (UTP23, RAD21, MED30, and EXT1) which are involved in fundamental cellular machineries.
Ming Hu   +9 more
wiley   +1 more source

IL-10 mediated by herpes simplex virus vector reduces neuropathic pain induced by HIV gp120 combined with ddC in rats

open access: yesMolecular Pain, 2014
BackgroundHIV-associated sensory neuropathy affects over 50% of HIV patients and is a common peripheral nerve complication of HIV infection and highly active antiretroviral therapy (HAART). Evidence shows that painful HIV sensory neuropathy is influenced
Wenwen Zheng   +6 more
semanticscholar   +1 more source

Comparative Analysis and Modeling of the Severity of Steatohepatitis in DDC-Treated Mouse Strains

open access: yesPLoS ONE, 2014
Background Non-alcoholic fatty liver disease (NAFLD) has a broad spectrum of disease states ranging from mild steatosis characterized by an abnormal retention of lipids within liver cells to steatohepatitis (NASH) showing fat accumulation, inflammation ...
V. Pandey   +15 more
semanticscholar   +1 more source

Indigenous Peoples in the U.S., Sovereign Nations, and the DDC

open access: yes, 2015
Claims of bias within the Dewey Decimal Classification (DDC) system in its treatment of indigenous peoples in the U.S. focus on marginalization through ghettoization, historicization, diasporization, and missing topics, such as the status of indigenous ...
Rebecca Green
semanticscholar   +1 more source

The CYP2E1 inhibitor DDC up-regulates MMP-1 expression in hepatic stellate cells via an ERK1/2- and Akt-dependent mechanism

open access: yesBioscience Reports, 2013
DDC (diethyldithiocarbamate) could block collagen synthesis in HSC (hepatic stellate cells) through the inhibition of ROS (reactive oxygen species) derived from hepatocyte CYP2E1 (cytochrome P450 2E1).
Tianhui Liu   +5 more
semanticscholar   +1 more source

Androgen Receptor Phosphorylation at Serine 308 and Serine 791 Predicts Enhanced Survival in Castrate Resistant Prostate Cancer Patients

open access: yesInternational Journal of Molecular Sciences, 2013
We previously reported that AR phosphorylation at serine 213 was associated with poor outcome and may contribute to prostate cancer development and progression.
P. McCall   +7 more
semanticscholar   +1 more source

A pairwise distance distribution correction (DDC) algorithm to eliminate blinking-caused artifacts in SMLM

open access: yesNature Methods, 2021
C. Bohrer   +12 more
semanticscholar   +1 more source

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