Results 11 to 20 of about 370,006 (97)

An Efficient CO₂-Upcycling Platform Based on Engineered Halomonas TD with Enhanced Acetate-Utilizing Capacity via Adaptive Laboratory Evolution. [PDF]

Adv Sci (Weinh)
An electrochemical system is designed to convert CO2 into CO2‐derived electrolytes (CDE), mainly containing acetate and formate. The underlying mechanism of acetate metabolism in Halomonas TD80 is explored via ALE. Engineered TD80 produced high‐yield diversified products from CDE.
Wang C, Chen TT, Yang YJ, Li YX, Chang YX, Xiao YC, Guo WT, Zheng Y, Deng RZ, Tian YX, Situ W, Shen HW, Chen Y, Wang YB, Xing J, Wang H, Xia L, Lin YN, Ye JW.   +18 more
europepmc   +2 more sources

Ergothioneine Treatment Ameliorates the Pathological Phenotypes of Parkinson's Disease Models. [PDF]

J Neurochem
We demonstrate here that the dietary compound Ergothioneine (ET) ameliorates the pathological phenotypes of a range of Parkinson's disease models, from Drosophila to mouse and patient‐derived human dopaminergic neurons. Our observations suggest that ET likely acts through the preservation of mitochondrial function to mediate its neuroprotective ...
Tng TJW, Leow DMK, Goh G, Wang Z, Liu Y, Tang RMY, Lai KCL, Basil AH, Choong HC, Goh WWB, Cheah IK, Ong WY, Halliwell B, Lim KL.   +13 more
europepmc   +2 more sources

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

Chronic Low‐Dose Unsymmetrical Dimethylhydrazine Exposure in Rats: Multiorgan Mechanisms and Biomarker Identification

Journal of Applied Toxicology, EarlyView.
ABSTRACT Unsymmetrical dimethylhydrazine (UDMH), a highly toxic rocket propellant with known multiorgan effects, requires urgent characterization of its chronic low‐dose toxicity. Using an integrated approach including exploratory transcriptomics (n = 3/group) and metabolomic (n = 4/group) approaches in male Sprague–Dawley rats exposed to high‐dose ...
Fuzhou Liu, Bing Liu, Keli Wang, Xiaoyu Wang, Zhen Sun, Xiaojuan Pan, Zengming Zhao   +6 more
wiley   +1 more source

The L108I polymorphism in mouse prion protein drives spontaneous disease and enhances transmission of atypical and classical prion strains

Brain Pathology, EarlyView.
A single amino acid change (L108I) combined with PrP overexpression drives spontaneous atypical prion formation in mice, enabling also efficient propagation of diverse prion strains. This model allows studying how spontaneous prion diseases arise and provides powerful tools for investigating strain emergence, transmission barriers, and mechanisms ...
Hasier Eraña, Enric Vidal, Natalia Fernández‐Borges, Jorge M. Charco, Carlos M. Díaz‐Domínguez, Cristina Sampedro‐Torres‐Quevedo, Josu Galarza‐Ahumada, Eva Fernández‐Muñoz, Maitena San‐Juan‐Ansoleaga, Miguel Ángel Pérez‐Castro, Nuno Gonçalves‐Anjo, Patricia Piñeiro, Samanta Giler, Nora González‐Martín, Nuria L. Lorenzo, Africa Manero‐Azua, Guiomar Perez de Nanclares, Mariví Geijo, Manuel A. Sánchez‐Martín, Jesús R. Requena, Joaquín Castilla   +20 more
wiley   +1 more source

Moderate increase of MET in hepatocytes protects against cholestatic liver injury by promoting an effective antioxidant response

The FEBS Journal, EarlyView.
Moderate overexpression of wild‐type Met in hepatocytes (Alb‐R26Met mouse model) boosts a strong antioxidant response dependent on the glutathione system while impairing TGF‐β signaling in the liver. This leads to improved liver regeneration and protects against DDC‐induced injury, a model for cholestatic disease sharing features with primary ...
Carlos González‐Corralejo, Juan García‐Sáez, María Figueroa‐Fuentes, Annalisa Addante, Cesáreo Roncero, Nerea Lazcanoiturburu, Beatriz Pacheco, Julián Sanz, Cristina Gato, Eva Fernández‐Calderón, María de la O López, Águeda González‐Rodríguez, Almudena Porras, Flavio Maina, Isabel Fabregat, Blanca Herrera, Aránzazu Sánchez   +16 more
wiley   +1 more source

A Case Report of Promising Response to Combination Therapy With an Immune Checkpoint Inhibitor (Pembrolizumab) and Multi‐Targeted Tyrosine Kinase Inhibitor (Pazopanib) in Metastatic De‐Differentiated Chondrosarcoma

Cancer Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background We present the case of 72–year‐old male with metastatic de‐differentiated chondrosarcoma (“DDCS”). DDCS is a rare soft tissue cancer that carries a dismal prognosis in the metastatic stage, and is resistant to both traditional chemotherapy and radiotherapy. There is a distinct lack of proven systemic therapies. Case This case report
Matthew Youssef, Peter Grimison
wiley   +1 more source

Management Strategies and Agricultural Calendars for Forage Production in Semi‐Arid Brazil Using AquaCrop

Irrigation and Drainage, Volume 75, Issue 1, Page 411-424, February 2026.
ABSTRACT Forage production in semi‐arid regions of Brazil is limited by water deficit. This study aimed to identify the most adapted and efficient production systems and define their agricultural calendars for the semi‐arid region of Brazil. Twenty‐nine production arrangements that included different cropping conditions, plant density, plant cycles ...
Antonio Gebson Pinheiro, Cleber Pereira Alves, Carlos André Alves de Souza, George do Nascimento Araújo Júnior, Alexandre Maniçoba da Rosa Ferraz Jardim, Regina Crisóstomo Grangeiro Pereira, José Edson Florentino de Morais, Luciana Sandra Bastos de Souza, Daniela de Carvalho Lopes, Antonio José Steidle Neto, Adriano Nascimento Simões, Fleming Sena Campos, Kaique Renan da Silva Salvador, João Emanoel Ambrósio Gomes, Enio Farias de Franca e Silva, Thieres George Freire da Silva   +15 more
wiley   +1 more source

Towards a Sustainable Future: Addressing Climate Change and Promoting Sustainable Development

Sustainable Development, Volume 34, Issue S1, Page 226-247, January 2026.
ABSTRACT This study aims to analyze policy research and global agreements on the decarbonization of economic development. Climate change and economic development are separate and equal, and strategies should separate responsibility from action. This will be required beyond the Kyoto and Paris agreements.
Woo‐Sik Sohn
wiley   +1 more source

Effect of High‐Pressure Processing Operating Parameters on Microbial Inactivation and Bioactive Protein Preservation in Bovine Milk: A Systematic Review

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 1, January 2026.
ABSTRACT In the U.S., bovine milk is processed using thermal pasteurization to ensure microbial safety. However, this process alters the structure of heat‐sensitive bioactive proteins associated with the functional benefits of raw milk, including antimicrobial, immunomodulatory, and antioxidant proteins.
Rudy Sykora, Caleb Mark, Marie Biondi Ryan, Bishal Barman, Michael Pitino, David C. Dallas   +5 more
wiley   +1 more source