Results 11 to 20 of about 1,748 (65)

A Plug-and-Play Platform for Customizing Multivalent Degraders and Degrader-Drug Conjugates. [PDF]

Adv Sci (Weinh)
Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Zhao M, Deng Y, Han J, Xie Y, Bao K, Ma L, Liu L, Mao W.   +7 more
europepmc   +2 more sources

Maximizing the Quality of Non-Invasive Samples for Conservation Genetics Using Targeted Next-Generation Sequencing: A Comparison of Fecal DNA Preservation Methodologies. [PDF]

Ecol Evol
Obtaining high quality and quantity fecal DNA is notoriously problematic. We compared seven different fecal DNA preservation methodologies for their performance with a targeted genotyping approach to better inform sampling of feces in the field. Optimal recovery of DNA was obtained via a lysis shaken (i.e., washed) methodology, which provided a yield ...
Levengood AL, Hohwieler K, Powell D, Cristescu RH.   +3 more
europepmc   +2 more sources

Prophage Activation Triggers Extracellular Synthesis of DNA in Bacterial Biofilms via Rolling Circle Replication

Angewandte Chemie, Volume 138, Issue 41, 5 October 2026.
Shewanella oneidensis and Bacillus subtilis, both harboring prophages, reveal a novel biosynthetic route to scalable and programmable DNA superstructures in flower‐ and wire‐like shapes, respectively. Activation of prophages is achieved via 3‐hour starvation and monitored using reporter strains.
Gabriel Antonio S. Minero, Line Mørkholt Lund, Lasse Hyldgaard Klausen, Obinna Markraphael Ajunwa, Mingdong Dong, Rikke Louise Meyer, Victoria Birkedal, Kai Thormann   +7 more
wiley   +2 more sources

Responsive nanoheterojunctions for built‐in electric field‐promoted cascade tumor targeting and cuproptosis‐based therapy

Responsive Materials, EarlyView.
Nanoheterojunctions have been synthesized as responsive biomaterials for cascade targeting of tumor cells and mitochondria, ROS‐mediated apoptosis and Cu‐promoted cuproptosis. And drug‐device‐field integration as an advanced paradigm of tumor treatment was employed for photo‐triggered tumor cell elimination in vitro and lesion eradication in vivo ...
Zhe Liu, Yandai Lin, Xuehui Li, Fengqi Xuan   +3 more
wiley   +1 more source

Anisotropic NMR as a Crucial Tool for Differentiation of Epimers With High Conformational Flexibility

Angewandte Chemie, Volume 138, Issue 30, 20 July 2026.
Epimer discrimination remains challenging due to subtle NMR differences. Here, we propose a methodology based on 13C‐RCSA and RDC anisotropic parameters, enabling the assignment of two flexible tetraprenyltoluquinol epimers (1a and 1b) with remote stereoclusters.
Juan Carlos C. Fuentes‐Monteverde, Abel M. Forero, Nilamoni Nath, Antonio Hernández Daranas, Carlos Jiménez, Jaime Rodríguez, Christian Griesinger   +6 more
wiley   +2 more sources

Mechanical stiffness orchestrates distinct regulation of MRTFs and YAP/TAZ transcriptional cofactors in hepatocytes

The FEBS Journal, EarlyView.
MRTFs and YAP/TAZ proteins, or mechanosensitive transcriptional cofactors (MRTcoF), regulate common genes associated with cellular contractility and immune cell infiltration. Their differential regulation in response to stiffness is linked to changes in hepatocyte's aspect ratio. MRTFB does not undergo nuclear translocation under these conditions. This
Brenda Selene Torres‐Ortiz, Daniel Pérez‐Calixto, Jorge Carretero‐Ortega, Aida Gabriela Guzman‐López, Diana Cristina Pinto‐Dueñas, Mariana Hernández‐Juárez, Alejandra Jiménez‐Escobar, Adriana Rodríguez‐Hernández, Beatriz Díaz‐Bello, Nathalia Serna‐Márquez, Miguel Ángel Peña‐Rico, Laura Gómez‐Romero, Francisco Gabriel Vázquez‐Cuevas, Genaro Vázquez‐Victorio   +13 more
wiley   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, Volume 58, Issue 5, Page 1413-1444, September 2026.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Molecular Mechanisms of Age‐Related Taste Dysfunction Deciphered by Spatiotemporal Transcriptomics

Aging Cell, Volume 25, Issue 9, September 2026.
Multi‐omics profiling reveals that aging impairs stem/progenitor cell differentiation and taste bud regeneration in the posterior tongue. Age‐related macrophage polarization remodeling, marked by the accumulation of pro‐inflammatory M1 macrophages, contributes to a Thbs1‐enriched inhibitory niche that limits taste cell growth and differentiation ...
Wandong Zhao, Xudong Cha, Yingqi Xie, Enhao Wang, Wenlu Xing, Zengyi Xu, Langchao Liang, Changhai Xiong, Morong Zhou, Penghui Fu, Zhe Wang, Xin Liu, Yiqun Yu, Huanhai Liu, Hanbo Li, Wenwen Ren   +15 more
wiley   +1 more source

Quantifying Daily Vertical Heat Flux in the Loop Current System: A Quasi‐Lagrangian Assessment of Frontal Hotspots

Geophysical Research Letters, Volume 53, Issue 15, 16 August 2026.
Abstract Vertical heat exchange within the upper ocean critically influences regional climate but remains difficult to observe directly. In the Gulf of Mexico, the Loop Current and its associated eddies significantly enhance this exchange. High‐resolution glider observations reveal that this transport is dominated by sub‐daily variability an order of ...
Sakib Mahmud, Xiao Ge, Uchenna Nwankwo, Anthony Knap, Steven F. DiMarco   +4 more
wiley   +1 more source

Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils

Advanced Science, Volume 13, Issue 47, 24 August 2026.
We show that immune cells (neutrophils) synthesize, uptake, and store catecholamine neurotransmitters such as dopamine or adrenaline. They also release them in response to specific stimuli (serotonin), which we directly visualize using fluorescent nanosensors. We further demonstrate that catecholamines affect neutrophil functions (NETosis) and platelet
Jennifer Mohr, Anne Schmitz, Meshkat Dinarvand, Franziska Wulfert, Sangeetha Shankar, Bjoern F. Hill, Michael Wojak, Juliana Gretz, Marie Britz, Elsa Neubert, Magdalena Shumanska, Sofia Kaushik, Linda Kartaschew, Ivan Bogeski, James Daniel, Sebastian Jung, Johannes Eble, Guido Wabnitz, Luise Erpenbeck, Sebastian Kruss   +19 more
wiley   +1 more source