Results 11 to 20 of about 40,231 (113)

Incidence of hypertension in people with HIV who are treated with integrase inhibitors versus other antiretroviral regimens in the RESPOND cohort consortium. [PDF]

HIV Med, 2022
Abstract Objective To compare the incidence of hypertension in people living with HIV receiving integrase strand transfer inhibitor (INSTI)‐based antiretroviral therapy (ART) versus non‐nucleoside reverse transcriptase inhibitors (NNRTIs) or boosted protease inhibitors (PIs) in the RESPOND consortium of HIV cohorts.
Byonanebye DM, Polizzotto MN, Neesgaard B, Sarcletti M, Matulionyte R, Braun DL, Castagna A, de Wit S, Wit F, Fontas E, Vehreschild JJ, Vesterbacka J, Greenberg L, Hatleberg C, Garges H, Gallant J, Volny Anne A, Öllinger A, Mozer-Lisewska I, Surial B, Spagnuolo V, Necsoi C, van der Valk M, Mocroft A, Law M, Ryom L, Petoumenos K, RESPOND study group.   +27 more
europepmc   +2 more sources

Melanin Synthesis Pathway Interruption: CRISPR/Cas9-mediated Knockout of dopa decarboxylase (DDC) in Harmonia axyridis (Coleoptera: Coccinellidae)

Journal of Insect Science, 2022
CRISPR/Cas9 technology is a very powerful genome editing tool and has been used in many insect species for functional genomics studies through targeted gene mutagenesis.
Meng-meng Wu, Xu Chen, Qingbiao Xu, L. Zang, Su Wang, Ming Li, D. Xiao   +6 more
semanticscholar   +1 more source

HAWC J2227+610 and Its Association with G106.3+2.7, a New Potential Galactic PeVatron [PDF]

Astrophysical Journal, 2020
We present the detection of very-high-energy gamma-ray emission above 100 TeV from HAWC J2227+610 with the High-Altitude Water Cherenov Gamma-Ray Observatory (HAWC) observatory.
A. Albert, R. Alfaro, C. Alvarez, J. Camacho, J. C. Arteaga-Vel'azquez, K. Arunbabu, D. Rojas, H. Solares, V. Baghmanyan, E. Belmont-Moreno, S. Benzvi, C. Brisbois, K. Caballero-Mora, T. Capistrán, A. Carramiñana, S. Casanova, U. Cotti, J. Cotzomi, S. León, E. D. L. Fuente, L. Díaz-Cruz, B. Dingus, M. DuVernois, J. C. Díaz-Vélez, R. Ellsworth, K. Engel, C. Espinoza, K. Fan, K. Fang, M. F. Alonso, H. Fleischhack, N. Fraija, A. Galv'an-G'amez, D. García, J. García-González, F. Garfias, G. Giacinti, M. Gonz'alez, J. Goodman, J. P. Harding, S. Hernández, J. Hinton, B. Hona, D. Huang, F. Hueyotl-Zahuantitla, P. Hüntemeyer, A. Iriarte, A. Jardin-Blicq, V. Joshi, William H. Lee, H. L. Vargas, J. Linnemann, A. Longinotti, G. Luis-Raya, J. Lundeen, K. Malone, S. Marinelli, O. Martinez, I. Martinez-Castellanos, J. Martínez-Castro, J. Matthews, P. Miranda-Romagnoli, J. Morales-Soto, E. Moreno, M. Mostafá, A. Nayerhoda, L. Nellen, M. Newbold, M. Nisa, R. Noriega-Papaqui, N. Omodei, A. Peisker, Y. Araujo, E. Pérez-Pérez, C. Rho, D. Rosa-González, E. Ruiz-Velasco, H. Salazar, F. Greus, A. Sandoval, Michael Schneider, H. Schoorlemmer, J. S. Franco, G. Sinnis, A. Smith, R. Springer, P. Surajbali, E. Tabachnick, M. Tanner, O. Tibolla, K. Tollefson, I. Torres, R. Torres-Escobedo, F. Ureña-Mena, L. Villaseñor, T. Weisgarber, A. Zepeda, Hong-lei Zhou, C. D. Le'on, J. Álvarez   +99 more
semanticscholar   +1 more source

Preclinical In Vitro Studies with 3D Spheroids to Evaluate Cu(DDC)2 Containing Liposomes for the Treatment of Neuroblastoma

Pharmaceutics, 2021
Preclinical in vitro studies of drug candidates for anticancer therapy are generally conducted on well-established 2D cell models. Unfortunately, these models are unable to mimic the properties of in vivo tumors.
F. Hartwig, Monika Köll-Weber, R. Süss
semanticscholar   +1 more source

Exosomal lncRNA CHL1-AS1 Derived from Peritoneal Macrophages Promotes the Progression of Endometriosis via the miR-610/MDM2 Axis

International Journal of Nanomedicine, 2021
Background Exosomes secreted by peritoneal macrophages (pMφ) are deeply involved in the development of endometriosis (EMs). Exosomes can mediate cell-to-cell communication by transferring biological molecules.
Ting Liu, Mei Liu, Caihua Zheng, Daoyan Zhang, Mingbao Li, Lu Zhang   +5 more
semanticscholar   +1 more source

Guidelines for mouse and human DC functional assays

European Journal of Immunology, Volume 53, Issue 12, December 2023., 2023
Conventional DC (cDC) represent a heterogenous family of professional antigen‐presenting cells. Basic functions common to all tissue‐resident cDC include antigen uptake, lymph node migration, and naive T cell priming to induce appropriate effector and regulatory T cell responses.
Björn E. Clausen, Lukas Amon, Ronald A. Backer, Luciana Berod, Tobias Bopp, Anna Brand, Sven Burgdorf, Luxia Chen, Meihong Da, Ute Distler, Regine J. Dress, Diana Dudziak, Charles‐Antoine Dutertre, Christina Eich, Anna Gabele, Melanie Geiger, Florent Ginhoux, Lucila Giusiano, Gloria J. Godoy, Ahmed E.I. Hamouda, Lukas Hatscher, Lukas Heger, Gordon F. Heidkamp, Lola C. Hernandez, Lukas Jacobi, Tomasz Kaszubowski, Wan Ting Kong, Christian H. K. Lehmann, Tamara López‐López, Karsten Mahnke, Dominik Nitsche, Jörg Renkawitz, Rifat A. Reza, Pablo J. Sáez, Laura Schlautmann, Madeleine T. Schmitt, Anna Seichter, Malte Sielaff, Tim Sparwasser, Patrizia Stoitzner, Giorgi Tchitashvili, Stefan Tenzer, Nounagnon R. Tochoedo, Damir Vurnek, Fabian Zink, Thomas Hieronymus   +45 more
wiley   +1 more source

Deep Learning‐Enabled Multiplexed Point‐of‐Care Sensor using a Paper‐Based Fluorescence Vertical Flow Assay

Small, Volume 19, Issue 51, December 20, 2023., 2023
A multiplexed point‐of‐care serodiagnosis assay is reported to simultaneously quantify three biomarkers of acute cardiac injury. This point‐of‐care sensor includes a paper‐based fluorescence vertical‐flow‐assay processed by a low‐cost mobile reader, which quantifies the target biomarkers using neural networks within <15 min per test using 50 µL of ...
Artem Goncharov, Hyou‐Arm Joung, Rajesh Ghosh, Gyeo‐Re Han, Zachary S. Ballard, Quinn Maloney, Alexandra Bell, Chew Tin Zar Aung, Omai B. Garner, Dino Di Carlo, Aydogan Ozcan   +10 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2023/24: Enzymes

British Journal of Pharmacology, Volume 180, Issue S2, Page S289-S373, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands.
Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jurg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +28 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2023/24: Transporters

British Journal of Pharmacology, Volume 180, Issue S2, Page S374-S469, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Laura Amarosi, Catriona M. H. Anderson, Philip M. Beart, Stefan Broer, Paul A. Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R. Hammond, Jules C. Hancox, Michal Hershfinkel, Ken‐ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R. S. Kunji, Gavin Stewart, Sotiria Tavoulari, David T. Thwaites, Tiziano Verri   +27 more
wiley   +1 more source

Variability in nutrient composition of the edible long‐horned grasshopper (Ruspolia differens) in Uganda and its potential in alleviating food insecurity

Food Science &Nutrition, Volume 11, Issue 6, Page 3558-3574, June 2023., 2023
Long‐horned grasshoppers are consumed in over 21 African countries. Crude protein (28%–45%), crude fat (41%–54%), and energy (582–644 Kj/100 g) of grasshoppers are comparable to that of plant and animal origins. Grasshopper meal could be considered as functional food ingredients capable of supplying adequate essential macro‐ and micronutrients ...
Margaret Kababu, Collins K. Mweresa, Sevgan Subramanian, James P. Egonyu, Chrysantus M. Tanga   +4 more
wiley   +1 more source