Results 11 to 20 of about 40,375 (65)

Melanin Synthesis Pathway Interruption: CRISPR/Cas9-mediated Knockout of dopa decarboxylase (DDC) in Harmonia axyridis (Coleoptera: Coccinellidae)

open access: yesJournal of Insect Science, 2022
CRISPR/Cas9 technology is a very powerful genome editing tool and has been used in many insect species for functional genomics studies through targeted gene mutagenesis.
Meng-meng Wu   +6 more
semanticscholar   +1 more source

HAWC J2227+610 and Its Association with G106.3+2.7, a New Potential Galactic PeVatron [PDF]

open access: yesAstrophysical Journal, 2020
We present the detection of very-high-energy gamma-ray emission above 100 TeV from HAWC J2227+610 with the High-Altitude Water Cherenov Gamma-Ray Observatory (HAWC) observatory.
A. Albert   +99 more
semanticscholar   +1 more source

Preclinical In Vitro Studies with 3D Spheroids to Evaluate Cu(DDC)2 Containing Liposomes for the Treatment of Neuroblastoma

open access: yesPharmaceutics, 2021
Preclinical in vitro studies of drug candidates for anticancer therapy are generally conducted on well-established 2D cell models. Unfortunately, these models are unable to mimic the properties of in vivo tumors.
F. Hartwig, Monika Köll-Weber, R. Süss
semanticscholar   +1 more source

Exosomal lncRNA CHL1-AS1 Derived from Peritoneal Macrophages Promotes the Progression of Endometriosis via the miR-610/MDM2 Axis

open access: yesInternational Journal of Nanomedicine, 2021
Background Exosomes secreted by peritoneal macrophages (pMφ) are deeply involved in the development of endometriosis (EMs). Exosomes can mediate cell-to-cell communication by transferring biological molecules.
Ting Liu   +5 more
semanticscholar   +1 more source

A wide-area GMRT 610-MHz survey of ELAIS N1 field [PDF]

open access: yes, 2020
In this paper we present a wide-area 610 MHz survey of the ELAIS\,N1 field with the GMRT, covering an area of 12.8 deg$^2$ at a resolution of 6 arcsec and with an rms noise of $\sim 40$ $\mu$Jy beam$^{-1}$. This is equivalent to $\sim 20$ $\mu$Jy beam$^{-
C. Ishwara-Chandra   +8 more
semanticscholar   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes

open access: yesBritish Journal of Pharmacology, Volume 178, Issue S1, Page S313-S411, October 2021., 2021
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander   +32 more
wiley   +1 more source

Revised Exon Structure of l-DOPA Decarboxylase (DDC) Reveals Novel Splice Variants Associated with Colorectal Cancer Progression

open access: yesInternational Journal of Molecular Sciences, 2020
Colorectal cancer (CRC) is a highly heterogenous malignancy with an increased mortality rate. Aberrant splicing is a typical characteristic of CRC, and several studies support the prognostic value of particular transcripts in this malignancy.
P. Artemaki   +7 more
semanticscholar   +1 more source

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Transporters

open access: yesBritish Journal of Pharmacology, Volume 178, Issue S1, Page S412-S513, October 2021., 2021
The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets ...
Stephen P H Alexander   +24 more
wiley   +1 more source

Deconstructing Fallacies in Products Liability Law to Provide a Remedy for Economic Loss

open access: yesAmerican Business Law Journal, Volume 58, Issue 2, Page 387-447, Summer 2021., 2021
For years, products liability law has failed to provide a remedy for consumers who suffer financial injury as a result of purchasing defective products manufacturers place and keep in the marketplace. The economic loss rule and defect manifestation requirements have, to date, foreclosed products liability claims when consumers suffer only economic ...
Alissa del Riego
wiley   +1 more source

L-Dopa-Decarboxylase (DDC) Is a Positive Prognosticator for Breast Cancer Patients and Epinephrine Regulates Breast Cancer Cell (MCF7 and T47D) Growth In Vitro According to Their Different Expression of Gi- Protein- Coupled Receptors

open access: yesInternational Journal of Molecular Sciences, 2020
A coherence between thyroid dysfunction and breast cancer incidence exists. Thyroid hormone metabolites bind to TAAR1 (trace amine-associated receptor 1) and through that modulate the serotonergic and dopaminergic system.
E. Tremmel   +8 more
semanticscholar   +1 more source

Home - About - Disclaimer - Privacy