Phosphodiesterase Inhibition Increases Striatal GDNF and Protects Against Preclinical Parkinsonism
Journal of Neurochemistry, Volume 169, Issue 12, December 2025.Parkinson's disease (PD) involves the progressive death of dopamine‐secreting neurons. This research investigates the neuroprotective role of the pharmacological inhibition of phosphodiesterases (PDE) by Ibudilast. This drug elevates levels of the signaling molecule cAMP, which boosts the production of GDNF, a potent neuroprotective factor naturally ...
Xavier d’Anglemont de Tassigny +3 more
wiley +1 more source
Determination of Aflatoxin M<sub>1</sub>, Organochlorine Pesticides, and Heavy Metals in Raw Milk of Iran. [PDF]
Food Sci NutrAnsari F +5 more
europepmc +1 more source
Mixed Outcomes in Recombination Rates After Domestication: Revisiting Theory and Data
Molecular Ecology, Volume 34, Issue 24, December 2025.ABSTRACT The process of domestication has altered many phenotypes. Selection on these phenotypes has long been hypothesised to indirectly select for increases in the genome‐wide recombination rate. This hypothesis is potentially consistent with theory on the evolution of the recombination rate, but empirical support has been unclear. We review relevant
Madeline Bursell +6 more
wiley +1 more source
Magnetic dispersive solid-phase extraction of organochlorine pesticides from honey samples in a narrow-bore tube prior to HPLC analysis. [PDF]
RSC AdvRasoulizadeh MA +2 more
europepmc +1 more source
A Classification System for Competing Narratives in a Risk Context
Risk Analysis, Volume 45, Issue 12, Page 5008-5022, December 2025.ABSTRACT Recent literature has examined the role of misinformation, biases, and other factors in contributing to the integrity of a risk study. These types of social and cognitive dynamics—referred to as narratives—comprise concern and value in a risk study. These narratives may appear to undermine aspects of objectivity in a scientific sense, but they
Shital Thekdi, Terje Aven
wiley +1 more source
Dual-Strategy Direct Photocatalytic Patterning for Efficient Perovskite Nanocrystal LED Displays. [PDF]
Adv MaterMaeng S +9 more
europepmc +1 more source
Veterinary Dermatology, Volume 36, Issue 6, Page 723-787, December 2025.Hyperkeratosis of (a) the footpads and (b) the nasal planum. ABSTRACT Background Canine leishmaniosis (CanL) due to Leishmania infantum remains common, and veterinarians do not always follow scientifically sound approaches for diagnosis, treatment and prevention. Objectives To provide consensus guidelines for diagnosis and evidence‐based guidelines for
Manolis N. Saridomichelakis +9 more
wiley +1 more source
Risk assessment of replacing synthetic preservatives with natural ingredients
EFSA Journal, Volume 23, Issue S1, December 2025.Abstract The present work, developed within the EU‐FORA fellowship programme, assessed the risk assessment of vegetable by‐product extracts as natural alternatives to synthetic preservatives in food formulations. Extracts were obtained from onion peel (Allium cepa L.), zucchini (Cucurbita pepo L.) and kale (Brassica oleracea L. var.
Tatiane C. G. Oliveira +8 more
wiley +1 more source
A Systematic Review of Aircraft Disinsection Efficacy. [PDF]
InsectsHawley G +7 more
europepmc +1 more source
c‐Abl Kinase Targets Tight Junction Protein ZO‐2 in Regulation of Cell Migration and Morphology
The FASEB Journal, Volume 39, Issue 22, 30 November 2025.c‐Abl binds and phosphorylates ZO‐2 directly at its C‐terminus and indirectly at the N‐terminus via JAK1. These phosphorylation events weaken cytoskeletal contractility, lower traction forces, and reduce cell migration, establishing ZO‐2 as a central mediator linking c‐Abl activity to changes in cell morphology and motility.
Doo Eun Choi +5 more
wiley +1 more source