Results 51 to 60 of about 36,954 (221)

Turning DDT into ‘Didimac’: Making insecticide products and consumers in British farming after 1945 [PDF]

, 2022
Sabine Clarke, Thomas Lean
openalex   +1 more source

Consensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...
Roland Froetschl, J. Christopher Corton, Henghong Li, Jiri Aubrecht, Scott S. Auerbach, Florian Caiment, Tatyana Y. Doktorova, Yurika Fujita, Danyel Jennen, Naoki Koyama, Matthew J. Meier, Roman Mezencev, Leslie Recio, Takayoshi Suzuki, Carole L. Yauk   +14 more
wiley   +1 more source

Residues of organochlorine pesticides in irrigated sierozem-meadow soils around buried chemicals stock

Soil and Water Research, 2018
The concentration and distribution of organochlorine pesticides (OCPs) were studied in sierozem-meadow soils around a buried obsolete chemicals stock in Mirzaabad district of Syrdarya region of Uzbekistan. 23 soil samples were collected from the topsoil (
Haytbay ARTIKOV, Martin KOČÁREK, Adéla FRAŇKOVÁ, Tokhtasin ABDRAKHMANOV, Luboš BORŮVKA, Umrbek SHARIPOV   +5 more
doaj   +1 more source

Review of Transcriptomic Biomarkers That Predict In Vitro Genotoxicity in Human Cell Lines

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The current genotoxicity testing paradigm provides little mechanistic information, has poor specificity in predicting carcinogenicity in humans, and is not suited to assessing a large number of chemicals. Genomic technologies enable the characterization of genome‐wide transcriptional changes in response to chemical treatments that can inform ...
Heng‐Hong Li, Jiri Aubrecht, Tatyana Y. Doktorova, Danyel Jennen, J. Christopher Corton, Roland Froetschl, Roman Mezencev, Carole L. Yauk   +7 more
wiley   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

Exercise‐specific plasma proteomic signatures in racehorses: Candidates for training adaptation and peak load monitoring

Equine Veterinary Journal, EarlyView.
Abstract Background Racehorses undergo profound physiological changes with training and competition, but current biomarkers inadequately capture the complex molecular dynamics of exercise. This study aimed to identify novel plasma biomarkers of training adaptation and peak load using high‐throughput proteomics.
Jowita Grzędzicka, Bianka Świderska, Ewa Sitkiewicz, Izabela Dąbrowska, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

A predictive analysis of insecticide resistance trend on Culex quinquefasciatus (Diptera: Culicidae) mosquito larvae over generations upon sublethal treatment with DDT, malathion and deltamethrin

Journal of Vector Borne Diseases
Background & objectives: Prior studies showed that repeated exposure of insecticides during the larval stage led to increase in vector resistance. However, gap of knowledge persisted in analysing the trend of insecticide resistance and cross resistance ...
Aditya Shankar Kataki
doaj   +1 more source

Occurrence and Human Health Implications of Legacy Organochlorine Pesticides and Their Metabolites in Fruits and Vegetables of Bangladesh

Food Safety and Health, EarlyView.
Multiple OCP isomers and/or metabolites along with their parent compounds were detected in commonly consumed fruits and vegetables of Bangladesh, possibly attributed to both recently and historically applied OCPs. However, all the detected values were below 0.01 mg/kg, indicating no potential human health risks through dietary intake. ABSTRACT Globally,
Kazi Sanjana Adnen, Shamima Jahan Sweety, Sadia Shahana Tisha, Md. Mahbubul Hoque, Tanmoy Roy Tusher   +4 more
wiley   +1 more source

Targeting papez circuit for cognitive dysfunction- insights into deep brain stimulation for Alzheimer's disease

Heliyon
Hippocampus is the most widely studied brain area coupled with impairment of memory in a variety of neurological diseases and Alzheimer's disease (AD).
Deepthi Rapaka, Motshegwana O. Tebogo, Elizabeth M. Mathew, Paul C. Adiukwu, Veera Raghavulu Bitra   +4 more
doaj   +1 more source

Evaluating the Endocrine‐Disrupting and Oxidative Stress Potential of a 50‐Component Human‐Relevant Complex Chemical Mixture Using In Vitro Tests

Journal of Applied Toxicology, EarlyView.
ABSTRACT Humans are chronically exposed to mixtures of environmental contaminants. Exposure to endocrine‐disrupting chemicals (EDCs) contributes to increased health impairment observed globally. This study aimed to evaluate the endocrine‐disruptive and oxidative stress potential of a human‐relevant, complex chemical mixture in vitro.
Josefin Engelhardt, Nathalie Struwe, Annika Jansson, Vesna Munic Kos, Maria Larsson, Jana M. Weiss   +5 more
wiley   +1 more source