Results 61 to 70 of about 10,098 (247)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Water Electrolysis Facing the Gigawatt Challenge—Comprehensive De‐Risking of Proton Exchange Membrane and Anion Exchange Membrane Electrolyser Technology

Electrochemical Science Advances
Green Hydrogen (H2) is generally considered to play a key role in enabling sustainable energy storage, as well as a renewable feedstock to various industrial sectors. Accordingly, the production of H2 by water electrolysis at an industrial scale is a key
André Karl, Eva Jodat, Hans Kungl, Ladislaus Dobrenizki, Günter Schmid, Peter Geskes, Rüdiger‐A. Eichel   +6 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Governing the de-risking agenda: policy instrument mixes in Scandinavian research collaboration with China

Education Inquiry
This article examines how de-risking policy instruments interact to shape implementation conditions for Sino-research collaboration in Danish, Norwegian and Swedish higher education institutions (HEIs).
Hans Lundin, Tommy Shih
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Os caminhos da reforma na Argentina e no Brasil The roads of reform in Argentina and Brazil

Lua Nova: Revista de Cultura e Política, 1998
As dinâmicas políticas das reformas orientadas para o mercado, no Brasil e na Argentina, são caracterizadas por um dilema, evidenciado em ambos os países pelas emendas de reeleição, entre manter a estabilidade das regras institucionais (e colocar em ...
Vicente Palermo
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Fiction et histoire dans Les Onze de Pierre Michon

Itinéraires, 2013
Pierre Michon’s Les Onze offers itself to be read as both an imaginary life and a meditation on art and history. In this text, the story of a painter, François-Élie Corentin, is intertwined with that of the French Revolution.
Souad Yacoub Khlif
doaj   +1 more source