Results 121 to 130 of about 563,940 (260)

De novo-engineered guide RNA-directed transposition with TnpB-family proteins. [PDF]

Mol Cell
Schargel RD, Chacon Machado L, Kumaran S, Thesier JE, Krishnan SS, Guarné A, Peters JE.   +6 more
europepmc   +1 more source

Self‐Assembling Copolymers Encapsulating Single Endothelial Cells Induce Endogenous ECM Deposition and Vascular Regeneration

Advanced Materials, EarlyView.
This study presents the first demonstration of stable sub‐50‐micron single‐cell GPM vesicles fabricated through the intrinsic self‐assembly of an amphiphilic copolymer. Hierarchical assembly of cell containing GPM vesicles into microspheres enable tunable, sustained cell delivery with immune protection.
Viola B. Morris, Sangho Lee, Kalp Soni, Simon He, Matthew Huang, Dandan Chen, Dae Hoon Lee, Kyung Hee Kim, Seonggeon Cho, Laura Pencea, Divit Jain, Young‐Sup Yoon   +11 more
wiley   +1 more source

Histopathological Differences Between De Novo and Nevus-Associated Melanoma. [PDF]

J Clin Med
Vasilovici AF, Zaiț MG, Ungureanu L, Grad AI, Cherecheș RM, Georgiu C, Șenilă SC.   +6 more
europepmc   +1 more source

Muscle Control of an Extra Robotic Digit

Advanced Robotics Research, EarlyView.
This study compares muscle‐ and movement‐based control for operating a supernumerary robotic thumb. While movement control performs better in the proposed tasks, muscle‐based (EMG) control promotes broader motor learning. The results highlight the promise and challenges of using biosignals for human augmentation, offering new insights into intuitive ...
Julien Russ, Lucy Dowdall, Francesco Cenciarelli, Kitty Goodridge, Mabel Ziman, Hristo Dimitrov, Danielle Clode, Tamar R. Makin   +7 more
wiley   +1 more source

De Novo Autogenic Engineered Living Functional Materials. [PDF]

Adv Mater
Hammad HM, Swarnadeep S, Jackson EC, Burns N, Wang H, Priode H, Moore RB, Deshmukh S, Manjula-Basavanna A, Duraj-Thatte AM.   +9 more
europepmc   +1 more source

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

Human acrocentric chromosome short-arm de novo mutation and recombination. [PDF]

Cell
Lin J, Mastrorosa FK, Noyes MD, Yoo D, Rhie A, Porubsky D, Hoekzema K, Munson KM, Koundinya N, Watkins WS, Jorde LB, Quinlan AR, Neklason DW, Phillippy AM, Eichler EE.   +14 more
europepmc   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

De Novo Synthesis in Cancer Immunotherapy: Applications and Prospects. [PDF]

MedComm (2020)
Jin Y, Wu Y, Luo J.
europepmc   +1 more source

De novo gene birth

PLOS Genetics, 2019
Stephen Branden Van Oss, Anne-Ruxandra Carvunis   +1 more
openaire   +3 more sources