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Nature Reviews Chemistry, 2021
Natural metalloproteins perform many functions - ranging from sensing to electron transfer and catalysis - in which the position and property of each ligand and metal, is dictated by protein structure. De novo protein design aims to define an amino acid sequence that encodes a specific structure and function, providing a critical test of the ...
Matthew J. Chalkley +2 more
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Natural metalloproteins perform many functions - ranging from sensing to electron transfer and catalysis - in which the position and property of each ligand and metal, is dictated by protein structure. De novo protein design aims to define an amino acid sequence that encodes a specific structure and function, providing a critical test of the ...
Matthew J. Chalkley +2 more
openaire +4 more sources
Neurosurgery, 1988
ABSTRACT The authors report two patients with aneurysmal subarachnoid hemorrhage in whom carotid arteriography revealed aneurysms that had developed at previously normal locations and from infundibula during the years since initial angiography. Neither of these patients had congenital anomalies of the cerebral circulation and, apart from
B K, Misra +3 more
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ABSTRACT The authors report two patients with aneurysmal subarachnoid hemorrhage in whom carotid arteriography revealed aneurysms that had developed at previously normal locations and from infundibula during the years since initial angiography. Neither of these patients had congenital anomalies of the cerebral circulation and, apart from
B K, Misra +3 more
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Human Genetics, 1975
A male infant is described with unusual facial appearance, clubfeet, and moderate hydrocephalus internus without obvious deficiency in mental and physical development. Cytogenetic studies revealed a karyotype of 45,XY,--C,--D,+t(C;D). A chromosome 11 and a 13 are involved in the formation of the translocation chromosome.
Christa Fonatsch +2 more
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A male infant is described with unusual facial appearance, clubfeet, and moderate hydrocephalus internus without obvious deficiency in mental and physical development. Cytogenetic studies revealed a karyotype of 45,XY,--C,--D,+t(C;D). A chromosome 11 and a 13 are involved in the formation of the translocation chromosome.
Christa Fonatsch +2 more
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American Journal of Medical Genetics, 1997
We report on a patient with psychomotor retardation and a pattern of malformations comprising single umbilical artery, craniofacial anomalies, severe truncal hypotonia, and lower-limb hyporreflexia. G-banding cytogenetics demonstrated a 16p+ chromosome. Parental chromosomes were normal.
J L, Carrasco Juan +4 more
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We report on a patient with psychomotor retardation and a pattern of malformations comprising single umbilical artery, craniofacial anomalies, severe truncal hypotonia, and lower-limb hyporreflexia. G-banding cytogenetics demonstrated a 16p+ chromosome. Parental chromosomes were normal.
J L, Carrasco Juan +4 more
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Voprosy neirokhirurgii imeni N.N. Burdenko, 2015
To substantiate the reasonability and duration of angiographic follow-up of patients operated on for cerebral aneurysms to rule out de novo aneurysm formation.The results of angiographic examination (cerebral angiography and SCT angiography) of 43 patients with cerebral aneurysms operated on at the Burdenko Neurosurgical Institute in 1995-2012 are ...
A S, Kheireddin +6 more
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To substantiate the reasonability and duration of angiographic follow-up of patients operated on for cerebral aneurysms to rule out de novo aneurysm formation.The results of angiographic examination (cerebral angiography and SCT angiography) of 43 patients with cerebral aneurysms operated on at the Burdenko Neurosurgical Institute in 1995-2012 are ...
A S, Kheireddin +6 more
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Novos modos de vigiar, novos modos de punir
2020As autoras fazem reflexões conceituais, a partir da história real de algumas crianças, sobre as raízes dos processos de patologização e medicalização da vida e os modos pelos quais tais processos se articulam com preconceitos e intolerância com as diferenças, com o silenciamento de questionamentos e de utopias.
Moysés, Maria Aparecida Affonso +1 more
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Genética na Escola, 2023
A domesticação de plantas permitiu que o homem realizasse seleção de espécies vegetais, passando a cultivá-las conforme suas necessidades, ao passo que elas se adaptaram ao cultivo em novos ambientes, o que deu origem à agricultura que conhecemos.
Rewysson Alves Ribeiro da Silva +5 more
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A domesticação de plantas permitiu que o homem realizasse seleção de espécies vegetais, passando a cultivá-las conforme suas necessidades, ao passo que elas se adaptaram ao cultivo em novos ambientes, o que deu origem à agricultura que conhecemos.
Rewysson Alves Ribeiro da Silva +5 more
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Science, 1999
One way in which the cell silences genes is to add methyl groups to cytosine (C) bases that are located next to guanine (G) bases in the DNA. The enzymes responsible for this are called the DNA methyltransferases (Dnmts). In a Perspective, Bird discusses several recent reports that identify two new Dnmts (Dnmt3a and 3b) and demonstrate that ...
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One way in which the cell silences genes is to add methyl groups to cytosine (C) bases that are located next to guanine (G) bases in the DNA. The enzymes responsible for this are called the DNA methyltransferases (Dnmts). In a Perspective, Bird discusses several recent reports that identify two new Dnmts (Dnmt3a and 3b) and demonstrate that ...
openaire +2 more sources
2003
The design of novel, pharmaceutically relevant compounds complementary to a given target binding site has long been considered as the “holy grail” in drug design.
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The design of novel, pharmaceutically relevant compounds complementary to a given target binding site has long been considered as the “holy grail” in drug design.
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2010
Computer-assisted molecular design supports drug discovery by suggesting novel chemotypes and compound modifications for lead structure optimization. While the aspect of synthetic feasibility of the automatically designed compounds has been neglected for a long time, we are currently witnessing an increased interest in this topic. Here, we review state-
Markus, Hartenfeller, Gisbert, Schneider
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Computer-assisted molecular design supports drug discovery by suggesting novel chemotypes and compound modifications for lead structure optimization. While the aspect of synthetic feasibility of the automatically designed compounds has been neglected for a long time, we are currently witnessing an increased interest in this topic. Here, we review state-
Markus, Hartenfeller, Gisbert, Schneider
openaire +2 more sources