Results 71 to 80 of about 4,559 (313)
, 2007 An exact solution of the vacuum Einstein equations with a cosmological constant is exhibited which can perhaps be used to describe the interior of compact rotating objects. The physical part of this solution has the topology of a torus, which may shed light on the origin of highly collimated jets from compact objects.
Chapline, G. F., Marecki, P.
openaire +2 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Magnetic charged particles of optical spherical antiferromagnetic model with fractional system
Open Physics, 2021 In this article, we first consider approach of optical spherical magnetic antiferromagnetic model for spherical magnetic flows of ϒ\Upsilon -magnetic particle with spherical de-Sitter frame in the de-Sitter space S12{{\mathbb{S}}}_{1}^{2}.
Yao Shao-Wen +5 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Bubbles in anti-de Sitter space
Physics Letters B, 2002 8 pages ...
Birmingham, D., Rinaldi, Massimiliano
openaire +6 more sources
Higher spin de Sitter Hilbert space [PDF]
Journal of High Energy Physics, 2019 Abstract We propose a complete microscopic definition of the Hilbert space of minimal higher spin de Sitter quantum gravity and its Hartle-Hawking vacuum state. The funda- mental degrees of freedom are 2N bosonic fields living on the future conformal boundary, where N is proportional to the de Sitter horizon entropy.
Anninos, Dionysios +3 more
openaire +8 more sources
Infinitesimal generators and quantum operators in de Sitter space
European Physical Journal C: Particles and FieldsThe 1 + 3-de Sitter space, as a solution of Einstein’s equations, provides a framework for investigating various physical concepts, including quantum mechanics.
A. Rabeie
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source