Results 111 to 120 of about 42,432 (292)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The Third Quantization: To Tunnel or Not to Tunnel?

open access: yesGalaxies, 2018
Within the framework of the third quantization, we consider the possibility that an initially recollapsing baby universe can enter a stage of near de Sitter inflation by tunnelling through a Euclidean wormhole that connects the recollapsing and ...
Mariam Bouhmadi-López   +3 more
doaj   +1 more source

Comment on the new AdS universe

open access: yes, 2008
We show that Bonnor's new Anti-de Sitter (AdS) universe and its D-dimensional generalization is the previously studied AdS soliton.Comment: 2 pages; version 2: major changes including the ...
Bayram Tekin   +3 more
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Avoiding Boltzmann Brain domination in holographic dark energy models

open access: yesPhysics Letters B, 2015
In a spatially infinite and eternal universe approaching ultimately a de Sitter (or quasi-de Sitter) regime, structure can form by thermal fluctuations as such a space is thermal.
R. Horvat
doaj   +1 more source

Conformal symmetry and accelerating cosmology in teleparallel gravity

open access: yes, 2013
We discuss conformal issues of pure and extended teleparallel gravity. In particular, we present formulations of conformal transformation in teleparallel gravity.
Bamba, Kazuharu   +2 more
core   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Anisotropic Cosmological Models with Two Fluids

open access: yesAdvances in High Energy Physics, 2018
Anisotropic dark energy cosmological models have been constructed in a Bianchi V space-time, with the energy momentum tensor consisting of two noninteracting fluids, namely, bulk viscous fluid and dark energy fluid.
B. Mishra, Pratik P. Ray, S. K. J. Pacif
doaj   +1 more source

Bounce Universe and Black Holes from Critical Einsteinian Cubic Gravity

open access: yes, 2017
We show that there exists a critical point for the coupling constants in Einsteinian cubic gravity where the linearized equations on the maximally-symmetric vacuum vanish identically. We construct an exact isotropic bounce universe in the critical theory
Feng, Xing-Hui   +3 more
core   +1 more source

Home - About - Disclaimer - Privacy