Results 121 to 130 of about 42,432 (292)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Arbitrary Dimensional Schwarzschild-FRW Black Holes

, 2004
The metric of arbitrary dimensional Schwarzschild black hole in the background of Friedman-Robertson-Walker universe is presented in the cosmic coordinates system.
Chang Jun Gao, Gu J-A, Kramer D, Liang C B, McVittie G C, Myers R C, Tangheilini F R   +6 more
core   +1 more source

Quantum stabilization of dilatonic Anti-de Sitter Universe

, 2002
The possibility of quantum creation of a dilatonic AdS Universe is discussed.Without dilaton it is known that quantum effects lead to the annihilation of AdS Universe. We consider the role of the form for the dilatonic potential in the quantum creation of a dilatonic AdS Universe.
Hurtado, John Quiroga, Shaido, Yulia A.
openaire   +3 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Friedmann-like universes with torsion

European Physical Journal C: Particles and Fields, 2019
We consider spatially homogeneous and isotropic cosmologies with non-vanishing torsion, which assumes a specific form due to the high symmetry of these universes.
Dimitrios Kranas, Christos G. Tsagas, John D. Barrow, Damianos Iosifidis   +3 more
doaj   +1 more source

Lectures on Holographic Space Time [PDF]

, 2013
Summary of three talks on the Holographic Space Time models of early universe cosmology, particle physics, and the asymptotically de Sitter final state of our universe.Comment: LaTex2e.
Banks, T.
core  

A parton picture of de Sitter space during slow-roll inflation

, 2009
It is well-known that expectation values in de Sitter space are afflicted by infra-red divergences. Long ago, Starobinsky proposed that infra-red effects in de Sitter space could be accommodated by evolving the long-wavelength part of the field according
A. Riotto, A.-C. Davis, B. Losic, C. Armendariz-Picon, C. Cheung, C. Cheung, C.T. Byrnes, D. Seery, D. Seery, D. Seery, D. Seery, D. Seery, D. Seery, D. Seery, D. Seery, D. Seery, D. Seery, D.H. Lyth, D.H. Lyth, D.I. Podolsky, David Seery, E. Dimastrogiovanni, E. Leader, E.A. Kuraev, E.A. Kuraev, E.J. Copeland, F. Larsen, F. Larsen, F. Vernizzi, G. Dissertori, G.I. Rigopoulos, I. Zaballa, I.I. Balitsky, I.I. Balitsky, J. Zinn-Justin, J.M. Maldacena, J.P. van der Schaar, K. Enqvist, K.E. Kunze, L. Amendola, L. Leblond, L. McLerran, L. McLerran, M. Sasaki, M. van der Meulen, M.E. Peskin, N. Bartolo, N.C. Tsamis, P. Creminelli, P. Creminelli, P.M. Saffin, P.R. Jarnhus, R.P. Feynman, S. Dubovsky, S. Shandera, T. Battefeld, T. Hattori, V.N. Gribov, V.N. Gribov, V.N. Gribov, V.N. Gribov, W. Unruh, W.G. Unruh, WMAP collaboration, Y. Urakawa, Y.L. Dokshitzer, Y.L. Dokshitzer   +66 more
core   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source