Results 111 to 120 of about 222,361 (282)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Navigation by Dead Reckoning and Local Cues

, 2017
According to comprehensive theories of navigation, animals navigate by using two complementary strategies: (1) dead reckoning informs the subject in a continuous manner on its actual location with respect to an Earthbound or absolute coordinate system ...
Etienne, A. S., Séguinot, V.
core  

Perancangan Robot Localization Menggunakan Metode Dead Reckoning

Jurnal Ilmiah SINERGI, 2014
Robot adalah sebuah system yang menarik, fungsinya banyak serta menghibur. Oleh karena itu, penyelidikan di bidang teknologi robot menjadi topik yang memiliki daya tarik yang cukup tinggi bagi para peneliti.
Andi Adriansyah
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Context-Aware Smartphone-Based 3D Indoor Positioning Using Pedestrian Dead Reckoning. [PDF]

Sensors (Basel), 2022
Khalili B, Ali Abbaspour R, Chehreghan A, Vesali N.   +3 more
europepmc   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Smartphone-Based Pedestrian Dead Reckoning for 3D Indoor Positioning. [PDF]

Sensors (Basel), 2021
Geng J, Xia L, Xia J, Li Q, Zhu H, Cai Y.   +5 more
europepmc   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Using dead-reckoning to track movements and map burrows of fossorial species

Animal Biotelemetry
Background Researching the movement patterns of fossorial animals and mapping of burrow systems presents a significant challenge due to the difficulty of direct observation and the limitations of most tracking systems to collect location fixes ...
James Redcliffe, Jesse Boulerice, Itai Namir, Rory Wilson, William J. McShea, Hila Shamon   +5 more
doaj   +1 more source