Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Indoor Trajectory Reconstruction of Walking, Jogging, and Running Activities Based on a Foot-Mounted Inertial Pedestrian Dead-Reckoning System. [PDF]
Sensors (Basel), 2020 Ceron JD +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
On rate gyros for improved navigation by reducing dead-reckoning errors
, 1998 Consider a vehicle using a number of landmarks for navigation. Between the observation of the landmarks, the motion of the vehicle is estimated using internal sensors like odometers and rate gyros.
Larsson, Ulf, +2 more
core
Research of Synchronization Algorithms in the Multi-channel Tiled Display System
工程科学与技术, 2012 :In order to solve the problem of frame images’ non-synchronization due to the imbalance overload of different rendering nodes, two synchronization algorithms were proposed which were the feedback verification and dead reckoning algorithm (FVDR) and ...
doaj
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Stereo perception and dead reckoning for a prototype lunar rover
, 1995 This paper describes practical, effective approaches to stereo perception and dead reckoning, and presents results from systems implemented for a prototype lunar rover operating in natural, outdoor environments.
Martial Hebert +2 more
core
SHAKF-PU: Sage-Husa Adaptive Kalman Filtering-Based Pedestrian Characteristic Parameter Update Mechanism for Enhancing Step Length Estimation in Pedestrian Dead Reckoning. [PDF]
Appl Bionics BiomechTseng CH, Wu JY.
europepmc +1 more source
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Pedestrian Dead Reckoning-Assisted Visual Inertial Odometry Integrity Monitoring. [PDF]
Sensors (Basel), 2019 Wang Y, Peng A, Lin Z, Zheng L, Zheng H.
europepmc +1 more source