Results 101 to 110 of about 4,046,052 (299)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Composing Songs for Dead Sailors

Toby Wren discusses his latest creative work, the Songs for Dead Sailors song cycle, a psychological exploration of love and loss in the time of tall ships. This project was conceived as creative practice scholarship.
Wren, Toby
core   +1 more source

Li2CO3-incorporated PVDF nanofiber network as lithium host enabling low N/P ratio lithium metal batteries

Nano Research
Lithium metal batteries are regarded as a solution for maximizing the energy density of Li-ion batteries. Ideally, the Li metal anode should be thin enough with a low negative to positive capacity ratio (N/P ratio ≤ 2), thus conserving the high-energy ...
Hilmy Nur Hidayat, Naufal Hanif Hawari, Aldan Hadziq Haidar, Qiang Zhu, Ning Ding, Qingyu Yan, Afriyanti Sumboja   +6 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Zhou yi lüe li

王弼, 韓康伯注 ; 孔穎達正義.綫裝, 1函.框19.7x13.1公分, 9行21字, 小字雙行同. 白口, 無魚尾, 四周單邊. 版心中鐫"易疏"及卷次, 下記刻工.分上,下經 ; 卷一至三為上經, 卷四至九為下經.出版項據《明代版本圖錄初編》推定.卷一至六由王弼注, 卷七至九由韓康伯注.With: 經典釋文 : 周易音義 / 陸德明撰 -- 周易略例 / 王弼撰.鈐有"呂氏樂房藏書", "得良館藏書記"印.Xian zhuang, 1 han.Kuang 19.7 x 13.1 gong ...

core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Manipulating the diffusion energy barrier at the lithium metal electrolyte interface for dendrite-free long-life batteries

Nature Communications
Constructing an artificial solid electrolyte interphase (SEI) on lithium metal electrodes is a promising approach to address the rampant growth of dangerous lithium morphologies (dendritic and dead Li0) and low Coulombic efficiency that plague ...
Jyotshna Pokharel, Arthur Cresce, Bharat Pant, Moon Young Yang, Ashim Gurung, Wei He, Abiral Baniya, Buddhi Sagar Lamsal, Zhongjiu Yang, Stephen Gent, Xiaojun Xian, Ye Cao, William A. Goddard, Kang Xu, Yue Zhou   +14 more
doaj   +1 more source

Response of pheochromocytoma neuronal cells to varying intensity of continuous wave terahertz radiation

Journal of Synchrotron Radiation
The effects of varying intensities of Australian Synchrotron source terahertz (THz) radiation on pheochromocytoma (PC 12) neuronal cells were investigated.
Denver P. Linklater, Palalle G. Tharushi Perera, Zoltan Vilagosh, Alexis Perez-Gonzalez, Phuc H. Le, Tanavi Sharma, Michael G. Leeming, Nicholas A. Williamson, Dominique Appadoo, Rodney Croft, Elena P. Ivanova   +10 more
doaj   +1 more source