Results 141 to 150 of about 232,677 (345)
CHARGE Syndrome: What an Otolaryngologist Should Know—A Systematic Review and Meta‐Analysis
Otolaryngology–Head and Neck Surgery, EarlyView.Abstract Objective To synthesize the prevalence of otolaryngologic manifestations in CHARGE syndrome (CS) to support otolaryngologists in delivering comprehensive management. Data Sources PubMed/MEDLINE, Embase, and Google Scholar were searched for English‐ and French‐language studies published from January 1980 through January 2025.
Camille Caron +5 more
wiley +1 more source
Studies of intercellular Ca2+ signaling and gap-junction coupling in the developing cochlea of mouse models affected by congenital hearing loss [PDF]
, 2013 Connexin 26 (Cx26) and connexin 30 (Cx30) form gap junction channels that allow the intercellular diffusion of the Ca2+ mobilizing second messenger IP3.
Rodriguez Hernandez, Laura
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Restoration, Not Bypass: Otoferlin Gene Therapy and a New Era in Hearing Loss Treatment
Otolaryngology–Head and Neck Surgery, EarlyView.Abstract The FDA approval of Otarmeni, an AAV‐based gene therapy for biallelic OTOF‐associated sensorineural hearing loss, represents a conceptual shift in otology: from bypassing defective auditory physiology to restoring it. Unlike cochlear implantation, which circumvents damaged sensory structures, OTOF gene replacement targets a synaptic deficit in
Jazlyn A. Selvasingh, Justin R. Shinn
wiley +1 more source
The Audiologic and Otolaryngologic Phenotype in WHIM Syndrome
Otolaryngology–Head and Neck Surgery, EarlyView.Abstract Objective WHIM syndrome (warts, hypogammaglobulinemia, infections, and myelokathexis syndrome) is an ultra‐rare primary immunodeficiency disease caused by autosomal dominant hyperfunctional mutations in the chemokine receptor CXCR4. Otolaryngologists are frequently consulted to evaluate WHIM patients because of recurrent acute ear and sinus ...
Christopher K. Zalewski +7 more
wiley +1 more source
Otolaryngology–Head and Neck Surgery, EarlyView.Abstract Objective Injection laryngoplasty is a standard‐of‐care intervention for unilateral vocal fold paralysis (UVFP), offering minimally invasive medialization with limited durability. We evaluated a regenerative injectable approach integrating an immunotolerant scaffold‐forming collagen (Oligomer) with autologous motor‐endplate expressing (MEE ...
Gabriel G. Sobczak +9 more
wiley +1 more source
Silent prison, Los Angeles, 1984
, 1984 Silent prison, 1984, 8th St. on-ramp to Harbor Fwy. (110) North. A deaf girl signing the word "hope." Done in honor of the World Games for the Deaf. by Margaret Garcia, assisted by five deaf youth. Acrylic, 24' x 14'. Sponsored by Greater L.A. Council on
Garcia, Margaret, Dunitz, Robin J.
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Effects of Minority Status on Sensory Outcomes, Cognition, and Depression
Otolaryngology–Head and Neck Surgery, EarlyView.Abstract Objective To evaluate the association between minority status and sensory function, sleep quality, depressive symptoms, and cognitive performance in an aging population. Study Design Prospective, cross‐sectional study. Setting Participants were recruited from the Department of Otolaryngology and the Center for Cognitive Neuroscience and Aging ...
Ivette Cejas +9 more
wiley +1 more source
Pediatric Anesthesia, EarlyView.ABSTRACT Background Language barriers continue to limit participation in international medical communication, and recent advances in artificial intelligence now enable real‐time voice translation to support multilingual scientific exchange. Approach: We describe a demonstration of a bidirectional AI‐mediated voice translation configuration at a ...
Clyde Matava +3 more
wiley +1 more source
TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia
CNS Neuroscience &Therapeutics, EarlyView., 2023 Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi +19 more
wiley +1 more source