Results 201 to 210 of about 337,480 (272)

Matrix metalloproteinase inhibition protects against junctophilin‐2 proteolysis during doxorubicin‐induced cardiotoxicity

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Treatment of cancer patients with anthracyclines is known to cause dose‐dependent cardiotoxicity through several mechanisms including enhanced oxidative stress, ultimately resulting in defective excitation–contraction coupling.
Wesam Bassiouni   +9 more
wiley   +1 more source

Organoid Models to Study Human Infectious Diseases

open access: yesCell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu   +4 more
wiley   +1 more source

Sudden unexpected infant death, sudden unexplained death in childhood, and sudden unexpected death in epilepsy

open access: yesDevelopmental Medicine &Child Neurology, Volume 67, Issue 6, Page 734-739, June 2025.
Abstract Sudden deaths in infants and children represent a profound and tragic event that continues to challenge researchers despite extensive investigation over several decades. The predominant phenotype, sudden infant death syndrome (SIDS), has evolved into the broader category of sudden unexpected infant death (SUID).
Suvasini Sharma   +3 more
wiley   +1 more source

Electrocardiograpic responses during spontaneous hypoglycaemia in people with type 1 diabetes and impaired awareness of hypoglycaemia

open access: yesDiabetic Medicine, EarlyView.
Abstract Aims Hypoglycaemia causes abnormal cardiac repolarisation, which has been related to sympathoadrenal activation. We examined whether individuals with type 1 diabetes (T1D) and impaired awareness of hypoglycaemia (IAH) were protected against proarrhythmogenic alterations on their electrocardiogram during clinical episodes of hypoglycaemia ...
Peter Novodvorsky   +9 more
wiley   +1 more source

A review of the safety of sodium‐glucose co‐transporter‐2 inhibitors

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract The development of sodium‐glucose co‐transporter‐2 (SGLT2) inhibitors represents a major turning point in the effort to preserve kidney function and prevent cardiovascular events and heart failure hospitalisations in those at high risk. These agents have now transcended their original glucose‐lowering indication and provide a range of clinical
Daniel Vincent O'Hara, Meg J. Jardine
wiley   +1 more source

The Unspoken Danger of the Mount Fuji Sign Leading to Sudden Death. [PDF]

open access: yesInt J Appl Basic Med Res
Singh S, Gupta V, Harish D, Singh A.
europepmc   +1 more source

Imaging predictors of adverse prognosis in Fabry disease cardiomyopathy: A systematic review and meta‐analysis

open access: yesEuropean Journal of Clinical Investigation, Volume 55, Issue 5, May 2025.
In this systematic review and meta‐analysis assessing the prognostic relevance of cardiac imaging parameters on adverse outcomes in patients with Fabry disease, we found that late gadolinium enhancement, left atrium volume indexed, E/e′ ratio, left ventricular (LV) mass indexed, maximum LV wall thickness and LV‐global longitudinal strain were ...
Kamil Stankowski   +13 more
wiley   +1 more source

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