Results 241 to 250 of about 238,134 (266)

Global and Temporal Trends in Utilization and Outcomes of Implantable Cardioverter Defibrillators in Hypertrophic Cardiomyopathy. [PDF]

open access: yesCirc Arrhythm Electrophysiol
Abdelfattah OM   +7 more
europepmc   +1 more source

Rescue of loss‐of‐function long QT syndrome‐associated mutations in KV7.1/KCNE1 by the endocannabinoid N‐arachidonoyl‐L‐serine (ARA‐S)

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Congenital long QT syndrome (LQTS) involves genetic mutations affecting ion channels, leading to a prolonged QT interval and increased risk of potentially lethal ventricular arrhythmias. Mutations in the genes encoding KV7.1/KCNE1 are the most frequent, with channel loss‐of‐function contributing to LQTS.
Irene Hiniesto‐Iñigo   +11 more
wiley   +1 more source

Organoid Models to Study Human Infectious Diseases

open access: yesCell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu   +4 more
wiley   +1 more source

The Uncommon Phenomenon of Short QT Syndrome: A Scoping Review of the Literature. [PDF]

open access: yesJ Pers Med
Boulmpou A   +8 more
europepmc   +1 more source

Sudden unexpected infant death, sudden unexplained death in childhood, and sudden unexpected death in epilepsy

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
Abstract Sudden deaths in infants and children represent a profound and tragic event that continues to challenge researchers despite extensive investigation over several decades. The predominant phenotype, sudden infant death syndrome (SIDS), has evolved into the broader category of sudden unexpected infant death (SUID).
Suvasini Sharma   +3 more
wiley   +1 more source

Electrocardiograpic responses during spontaneous hypoglycaemia in people with type 1 diabetes and impaired awareness of hypoglycaemia

open access: yesDiabetic Medicine, EarlyView.
Abstract Aims Hypoglycaemia causes abnormal cardiac repolarisation, which has been related to sympathoadrenal activation. We examined whether individuals with type 1 diabetes (T1D) and impaired awareness of hypoglycaemia (IAH) were protected against proarrhythmogenic alterations on their electrocardiogram during clinical episodes of hypoglycaemia ...
Peter Novodvorsky   +9 more
wiley   +1 more source

Global, regional and country‐specific burden of chronic kidney disease due to type 1 diabetes mellitus: A systematic analysis of the 2021 global disease burden study

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Chronic kidney disease (CKD) affects individual welfare, healthcare systems and societal progress. Of the multifaceted etiological factors, type 1 diabetes mellitus (T1DM) is a prominent contributor to CKD. Materials and Methods We analysed the global incidence, prevalence, deaths and disability‐adjusted life‐years (DALYs) with age ...
Jianran Sun   +5 more
wiley   +1 more source

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