Results 241 to 250 of about 261,307 (299)

Cardiac remodelling in type 2 diabetes: Pathophysiological mechanisms and opportunities for multiscale computational modelling and simulation

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of multiscale cardiac remodelling in type 2 diabetes and how to model and simulate these changes using a human‐based, multiscale computational framework. Cardiac remodelling in type 2 diabetes occurs at ionic channel, protein, cellular, tissue and whole‐organ level, affecting the electrophysiological function, mechanical
Ambre Bertrand, Jakub Tomek, Blanca Rodriguez   +2 more
wiley   +1 more source

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

Leisure-time physical activity and risk of sudden cardiac death: a 28-year follow-up from the Copenhagen City Heart Study. [PDF]

EClinicalMedicine
Isozaki S, Skjelbred T, Warming PE, Casarini E, Prescott EIB, Jabbari R, Mujkanovic J, Tfelt-Hansen J.   +7 more
europepmc   +1 more source

In silico modelling of multi‐electrode arrays for enhancing cardiac drug testing on hiPSC‐CM heterogeneous tissues

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the experimental and computational framework for investigating hiPSC‐CM electrophysiology with MEA systems. The MEA‐based model integrates experimental data with phenotype‐specific ionic models and tissue‐level heterogeneity.
Sofia Botti, Rolf Krause, Luca F. Pavarino   +2 more
wiley   +1 more source

Post-Mortem Biomarkers in Sudden Cardiac Death: From Classical Biochemistry to Molecular Autopsy and Multi-Omics Forensic Approaches. [PDF]

Int J Mol Sci
Sacco MA, Mastrangelo H, Neri G, Aquila I.   +3 more
europepmc   +1 more source

Computational analysis to assess hemodynamic forces in descending thoracic aortic aneurysms

The Journal of Physiology, EarlyView.
Abstract figure legend Left: Pre‐processing. First, we perform the segmentation of the Computer Tomography angiorgraphy (angio‐CT) scans of a healthy patient, obtaining the surface of a healthy thoracic aorta with a Type III aortic arch. Then, we build nine ideal configurations with Descending Thoracic Aortic Aneurysm (DTAA), varying the aortic arch ...
Francesca Duca, Daniele Bissacco, Luca Crugnola, Chiara Faitini, Maurizio Domanin, Francesco Migliavacca, Santi Trimarchi, Christian Vergara   +7 more
wiley   +1 more source

25-Year Evolution of Apical Hypertrophic Cardiomyopathy in a Professional Athlete. [PDF]

JACC Case Rep
Papatheodorou E, Vlagkouli V, Anastasakis A.   +2 more
europepmc   +1 more source

Perioperative mortality in patients with acute aortic dissection and coronary artery problems: report of 3 cases and literature review. [PDF]

AME Case Rep
Ma S, Ren J.
europepmc   +1 more source