Results 41 to 50 of about 5,535 (166)

An Investigation of Hyperostosis Frontalis Interna in a Modern Anatomical Body Donor Population

Clinical Anatomy, EarlyView.
ABSTRACT This research sought to examine the prevalence and severity of hyperostosis frontalis interna (HFI) in the Chicagoland anatomical body donor population. The study further aimed to elucidate potential demographic risk factors for HFI, including sex, age at death, and structural vulnerability index (SVI), as well as any common comorbidities, as ...
Amy C. Beresheim, Amanda Hall
wiley   +1 more source

A Streamline Strategy for Indication and Length of Telemetry Monitoring After TAVR

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Both indication and length of ECG telemetry monitoring (TM) after transcatheter aortic valve replacement (TAVR) are not well defined. Aims We hypothesize that a targeted strategy for monitoring conductive disorders (CD) post‐TAVR can reduce the need and duration of in‐hospital TM without compromising safety. Methods We prospectively
Antonin Fournier, Pierre Robert, Benoit Lattuca, Claire Duflos, Maël‐Morvan Duroyon, Jean‐Christophe Macia, Laurent Schmutz, Matthieu Steinecker, Jean‐Michel Berdeu, Thomas Gandet, Jean Luc Pasquie, François Roubille, Guillaume Cayla, Florence Leclercq   +13 more
wiley   +1 more source

Synthesis and In Vitro Activity of Hypofuran B and Analogs Against Plasmodium Falciparum and Trypanosoma Cruzi

ChemMedChem, EarlyView.
Hypofuran B, drynaran, and a series of analogs are obtined by crossed aldol condensation from furfural dereivatives. Compunds are tested for in vitro activity agaisnt Trypanosoma cruzi and Plasmodium falciparum. Best results are obtained Against P. falciparum, with IC50 values ranging from 5,35 to 10,35 µg mL−1.
Cristiane Aparecida Franco, Jodieh Oliveira Santana Varejão, Isabela Penna Ceravolo, Victória Miranda Machado, Antoniana Ursine Krettli, Daniela de Melo Resende, Silvane Maria Fonseca Murta, Felipe Terra Martins, Eduardo Jorge Pilau, Vinícius Ribeiro Montes, Markus Kohlhoff, Eduardo V. V. Varejão   +11 more
wiley   +1 more source

Mitochondrial DNA polymorphisms in individuals died from sudden cardiac death

Фундаментальная и клиническая медицина, 2019
Aim. To identify associations of mtDNA polymorphisms with sudden cardiac death.Materials and Methods. DNA was isolated from the cardiac tissue excised during the autopsy from individuals who died from sudden cardiac death (n = 260).
M. V. Golubenko, A. V. Tsepokina, R. R. Salakhov, V. N. Maksimov, A. A. Gurazheva, B. A. Tkhorenko, A. V. Ponasenko   +6 more
doaj   +1 more source

Natural History of Alternating Hemiplegia of Childhood: Vulnerabilities in Early Childhood and Predictive Factors for Long‐Term Outcomes

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Objective The natural history of the most common ATP1A3‐related disease, alternating hemiplegia of childhood (AHC), has not been determined. We investigated three hypotheses: (1) AHC worsens over time; (2) several novel factors correlate with long‐term outcomes; and (3) AHC manifests high mortality.
Shital H. Patel, Eleni Panagiotakaki, Beiyu Liu, Carmen Fons, Lyndsey Prange, Maria T. Papadopoulou, April Boggs, Elisa De Grandis, Aikaterini Vezyroglou, Francesco Fortunato, Simona Balestrini, Francesca Ragona, Eugenia Julia Tosi, Claudio Zucca, Giacomo Garone, Andrey Megvinov, Giosuè Lo Bosco, Michela Stagnaro, Julie Uchitel, Marion Comajuan, Matthildi Athina Papathanasiou Terzi, Jennifer Anticona, Joan M. Jasien, Jeffrey Wuchich, Sigurdur H. Johannesson, J. Narayan, J. Helen Cross, Sanjay M. Sisodiya, Hwanhee Hong, Alexis Arzimanoglou, Rosaria Vavassori, Mohamad A. Mikati   +31 more
wiley   +1 more source

Why We Do Not Recommend That People With High‐Risk Smoldering Myeloma Receive Treatment

American Journal of Hematology, EarlyView.
Ghulam Rehman Mohyuddin, Mackenzie Lemieux, Rajshekhar Chakraborty, Morie Gertz   +3 more
wiley   +1 more source

Concentration–QTc Modeling to Support Clinical Development of Fezolinetant

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Fezolinetant is a non‐hormonal, selective neurokinin‐3 receptor antagonist that blocks neurokinin B activation of kisspeptin/neurokinin B/dynorphin neurons to thereby modulate neuronal activity in the thermoregulatory center. Fezolinetant has been approved in many regions, including North America, Europe, Asia, and Australia for the treatment ...
Jace C. Nielsen, Masako Saito, Xuegong Wang, Megumi Iwai, Graeme L. Fraser, Steven Ramael, Jiayin Huang   +6 more
wiley   +1 more source

Drug‐Induced QT Prolongation: Associations Between Risk Classifications in a Swedish Clinical Decision Support System and Clinical Outcomes

Clinical Pharmacology &Therapeutics, EarlyView.
Potential adverse drug events can be signaled in Clinical Decision Support Systems (CDSSs). This study validated a Swedish CDSS (Janusmed Risk Profile) by investigating associations between calculated risk classifications of drugs with QT‐prolonging potential and registered related clinical outcomes.
Ola Nordqvist, Olof Björneld, Patrick Bergman, Björn Wettermark, Alisa Lincke, Marine L. Andersson, Tora Hammar   +6 more
wiley   +1 more source

Metabolic changes during cardiac regeneration in the axolotl

Developmental Dynamics, EarlyView.
Abstract Background The axolotl is a prominent model organism of heart regeneration due to its ability to anatomically and functionally repair the heart after an injury that mimics human myocardial infarction. In humans, such an injury leads to permanent scarring. Cardiac regeneration has been linked to metabolism and the oxygenation state, but so far,
Anita Dittrich, Sofie Amalie Andersson, Morten Busk, Kasper Hansen, Casper Bindzus Foldager, Johan Palmfeldt, Asger Andersen, Michael Pedersen, Mikkel Vendelbo, Kirstine Lykke Nielsen, Henrik Lauridsen   +10 more
wiley   +1 more source

Genetic Aspects of Hereditary Arrhythmogenic Syndromes in Children and Adults

Acta Clinica Croatica, 2017
Recent research has revealed the genetic etiology of a number of heart diseases that cause sudden cardiac death. Lethal channelopathies are of great importance among the genetically determined heart diseases. Their basic characteristics are unpredictable
Vesna Miranović, Snežana Crnogorac
doaj   +1 more source