Results 51 to 60 of about 462,679 (319)

"Re-evaluation of variants of uncertain significance in patients with hereditary arrhythmogenic disorders"

BMC Cardiovascular Disorders
Background Genetic diagnostics support the diagnosis of hereditary arrhythmogenic diseases, but variants of uncertain significance (VUS) complicate matters, emphasising the need for regular reassessment.
Sarah Martin, Tina Jenewein, Christof Geisen, Stefanie Scheiper-Welling, Silke Kauferstein   +4 more
doaj   +1 more source

Actionable Variants of Unknown Significance in Inherited Arrhythmogenic Syndromes: A Further Step Forward in Genetic Diagnosis

Biomedicines
Background/Objectives: Inherited arrhythmogenic syndromes comprise a heterogenic group of genetic entities that lead to malignant arrhythmias and sudden cardiac death.
Estefanía Martínez-Barrios, Andrea Greco, José Cruzalegui, Sergi Cesar, Nuria Díez-Escuté, Patricia Cerralbo, Fredy Chipa, Irene Zschaeck, Miguel Fogaça-da-Mata, Carles Díez-López, Elena Arbelo, Simone Grassi, Antonio Oliva, Rocío Toro, Georgia Sarquella-Brugada, Oscar Campuzano   +15 more
doaj   +1 more source

Aborted sudden cardiac death due to ventricular fibrillation in a female patient with mitral valve prolapse

Cardiovascular Ultrasound, 2021
Background Mitral valve prolapse is the most frequent valvular defect associated with a wide range of electro-hemodynamic abnormalities, leading to heart failure, arrhythmias and sudden cardiac death. Mitral valve prolapse, first described from Barlow in
Sofien Ayed, Rainer Hoffmann
doaj   +1 more source

Risk Stratification for Sudden Cardiac Death In Patients With Non-ischemic Dilated Cardiomyopathy [PDF]

, 2005
Non ischemic dilated cardiomyopathy (NIDCM) is a disorder of myocardium. It has varying etiologies. Albeit the varying etiologies of this heart muscle disorder, it presents with symptoms of heart failure, and rarely as sudden cardiac death (SCD ...
Ghosh, Joydeep, Greenberg, Yisachar, Shekha, Karthik, Thekkoott, Deepak   +3 more
core   +1 more source

Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies [PDF]

, 2009
To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation associated with risk of ventricular arrhythmias and sudden cardiac death, we conducted a meta-analysis of three genome-wide association studies (GWAS ...
Andrew D. Paterson, Anna Dominiczak, Arne Pfeufer, Chris Wallace, Christopher Newton-Cheh, Chrysoula Dalageorgou, Dan E. Arking, Daryl Waggott, Dongling Zheng, Eleftheria Zeggini, Folkert W. Asselbergs, Harold Snieder, Ilja M. Nolte, Irina Savelieva, Jingyuan Fu, John Connell, Kenneth Rice, Louise V. Wain, Mark Caulfield, Mark Eijgelsheim, Mark Lathrop, Martin Farrall, Martin Tobin, Morris Brown, Nicholas D. Carter, Nicole Soranzo, Nilesh J. Samani, null null, null null, null null, null null, Panos Deloukas, Patricia B. Munroe, Paul I. W. de Bakker, Rhian Gwilliam, Serena Sanna, Stephen J. Newhouse, Steve Jeffery, Tim D. Spector, Yalda Jamshidi   +39 more
core   +10 more sources

A Novel Theoretical Hypothesis on Comorbidity in the Elderly—The Disease of Sympathetic Overdrive (DSO)

AGING MEDICINE, EarlyView.
A novel hypothesis: The disease of sympathetic overdrive (DSO) as a unifying mechanism for comorbidity in the elderly. ABSTRACT The coexistence of multimorbidity and geriatric syndromes is a big character and role target to manage for the clinic works in older age, but related theories still require innovation and exploration.
Li Jie, Kong Jian, Yu Boxin, Li Hongyang
wiley   +1 more source

Deporte y síndromes arritmogénicos hereditarios (Sport and inherited arrhythmogenic syndromes)

Retos: Nuevas Tendencias en Educación Física, Deportes y Recreación
Los síndromes arritmogénicos hereditarios son un grupo de patologías cardiacas asociadas a arritmias malignas y un mayor riesgo de muerte súbita cardiaca, en ocasiones la primera manifestación de la patología.
Georgia Sarquella-Brugada, Estefanía Martínez-Barrios, Sergio Cesar, Elena Arbelo, Carles Diez, Oscar Campuzano Larrea   +5 more
doaj   +1 more source

Myocardial lipofuscin accumulation in ageing and sudden cardiac death

Scientific Reports, 2019
Lipofuscin is an intracellular aggregate of highly oxidized proteins that cannot be digested in the ubiquitin-proteasome system and accumulate mainly in lysosomes, especially in aged cells and pathological conditions.
Y. Kakimoto, Chisa Okada, N. Kawabe, Ayumi Sasaki, H. Tsukamoto, Ryoko Nagao, M. Osawa   +6 more
semanticscholar   +1 more source

How Sudden Is Sudden Cardiac Death? [PDF]

Circulation, 2006
Background— Out-of-hospital sudden cardiac death (SCD) is a frequent cause of death. Survival rates remain low despite increasing efforts in medical care. Better understanding of the circumstances of SCD could be helpful in developing preventive measures and facilitating proper reactions to such a ...
Rahul Agrawal, Dirk Müller, Hans-Richard Arntz   +2 more
openaire   +2 more sources

Sudden cardiac death [PDF]

, 2008
Sudden cardiac death (SCD) continues to be a major health issue in many countries including Malaysia due to its large magnitude in all-cause mortality as well as the emotional and socioeconomic impact of the deceased leaving the love ones behind in an ...
Abd. Rahim, Firdaus, Guan, Yap Yee
core