Results 131 to 140 of about 258,379 (262)

Responsive stimulation of the thalamus for idiopathic generalized epilepsy: Results of the randomized controlled NAUTILUS trial through 18 months

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to evaluate the safety and effectiveness of responsive thalamic stimulation as adjunctive therapy for drug‐resistant idiopathic generalized epilepsy (IGE) with generalized tonic–clonic seizures (GTCSs). Methods NAUTILUS is a prospective, multicenter, single‐blind, randomized sham‐controlled pivotal trial ...
Utku Uysal, Patrick Landazuri, David E. Burdette, Sanjay Patra, Angela N. Crudele, Dario J Englot, Jay R. Gavvala, Sandipan Pati, Lesley C. Kaye, Steven Ojemann, Daniel Barnett, Joseph Neimat, Adriana E. Palade, Shervin Rahimpour, Amir A. Arain, Robert Mark Richardson, Sydney S. Cash, Vicenta Salanova, Alexandra Urban, William P. Welch, Jamie Joseph Van Gompel, Keith Starnes, David Spencer, Lia D. Ernst, Ushtar Amin, Angelica Rivera‐Cruz, Patricia Dugan, Marytery Fajardo, Matt Lallas, Barbara C. Jobst, Nicole Odom, Jarod L. Roland, Jon T. Willie, Sameer A. Sheth, Alica M. Goldman, Christopher T. Skidmore, Chengyuan Wu, Cornelia Drees, Jonathon Parker, Taneeta Mindy Ganguly, Jerzy Szaflarski, Saadi Ghatan, Lise Johnson, Jacob Norman, Brett Wingeier, Cairn G. Seale, Martha J. Morrell, Nautilus Study Group   +47 more
wiley   +1 more source

Tonic–clonic seizures captured during ambulatory video‐EEG are frequently unreported

Epilepsia, EarlyView.
Abstract Objective Tonic–clonic seizures (TCSs) are widely regarded as clinically obvious, yet seizure counts used for treatment decisions and risk counseling often rely on patient or caregiver diaries. We sought to quantify the frequency of unreported TCSs during prolonged ambulatory video‐EEG (vEEG) monitoring and examined associations with ...
Ewan S. Nurse, Jacqueline French, Victoria Wong, Mark Cook   +3 more
wiley   +1 more source

Pathology of sudden death in racehorses: a review. [PDF]

J Vet Diagn Invest
Uzal FA, Asin J, Diab S, Henderson E, Engiles JB, Kennedy L, Schild C.   +6 more
europepmc   +1 more source

Compensatory rearrangement of parvalbumin interneuron voltage‐gated sodium channel subunits in a mouse model of Dravet syndrome

Epilepsia, EarlyView.
Abstract Heterozygous loss‐of‐function variants in the gene SCN1A, which encodes the voltage‐gated sodium channel (VGSC) pore‐forming (α) subunit NaV1.1, lead to a spectrum of neurological disease, including Dravet syndrome. NaV1.1 is prominently expressed at the proximal portion of the axon initial segment (AIS) of fast‐spiking γ‐aminobutyric ...
Ania K. Dabrowski, Ala Somarowthu, Sophie R. Liebergall, Damaris N. Lorenzo, Ethan M. Goldberg   +4 more
wiley   +1 more source

Trends in sudden death-attributed mortality across Europe, 2010-2020: a retrospective population-based analysis. [PDF]

Lancet Reg Health Eur
Zuin M, Marijon E, Narayanan K, Vitali F, Bilato C, Temporelli PL, De Caterina R, Themistoclakis S, Oliva F, De Luca L, Colombo C, Balla C, Malagù M, Canovi L, Boriani G, Bertini M.   +15 more
europepmc   +1 more source

Sudden Unexplained Nocturnal Death Syndrome: The Hundred Years' Enigma

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
Jingjing Zheng, Da Zheng, Terry Su, Jianding Cheng   +3 more
doaj   +1 more source

Biomarker, Functional Status, and Quality-of-Life Trajectories Before Modes of Death in Heart Failure: Post Hoc Analysis of the FINEARTS-HF Randomized Clinical Trial.

JAMA Cardiol
Lu H, Kosztin A, Claggett BL, Foà A, Pabón MA, Desai AS, Jhund PS, Henderson AD, Merkely B, Lam CSP, Senni M, Shah SJ, Voors AA, Zannad F, Pitt B, Amarante F, Saarinen R, De Sanctis Y, Glasauer A, McMurray JJV, Vaduganathan M, Solomon SD.   +21 more
europepmc   +1 more source

Gamma suppression correlates with thalamic stimulation therapeutic response in intractable epilepsy

Epilepsia, EarlyView.
Abstract Objective In patients with drug‐resistant epilepsy who undergo anterior nucleus of the thalamus (ANT) deep brain stimulation (DBS), efficacy is assessed months after therapy initiation and clinicians have no guidance when choosing stimulation parameters due to the lack of real‐time biomarkers.
Zachary T. Sanger, Xinbing Zhang, Thomas Lisko, Hafsa Farooqi, Steffen Ventz, Sandipan Pati, Thomas R. Henry, David P. Darrow, Michael C. Park, Theoden I. Netoff, Robert A. McGovern   +10 more
wiley   +1 more source

Signal-averaged electrocardiography in horses: characteristics of ventricular late potentials in healthy Thoroughbreds and horses with cardiac abnormalities. [PDF]

J Equine Sci
Seki N, Tochinai R, Sekizawa SI, Ohmura H, Ueno T, Fukuda K, Kuwahara M.   +6 more
europepmc   +1 more source

Effectiveness and tolerability of fenfluramine in pediatric and adult patients with developmental and epileptic encephalopathies: A multicenter, retrospective, real‐world clinical‐practice study

Epilepsia, EarlyView.
Abstract Objective Developmental and epileptic encephalopathies (DEEs) are characterized by drug‐resistant seizures and developmental slowing/regression. We examined the efficacy and tolerability of fenfluramine (FFA) in pediatric and adult patients with Lennox–Gastaut syndrome (LGS), Dravet syndrome (DS), and other DEEs.
Vicente Villanueva, Elena González‐Alguacil, Patricia Smeyers, Sara Hernández, Victor Soto‐Insuga, Alejandro Fernández‐Cabrera, Laura Olivié, Teresa de Santos, Beatriz Parejo, Lucas Iacampo, Belén Ortuño, Javier Aparicio, Montserrat Fuentes, Juan Rodriguez‐Uranga, Paula Martínez‐Agredano, José Carlos Estévez, Angel Aledo‐Serrano, Rocio Martin‐Alvarez, David Conejo, Belen Baena, Blanca Mercedes‐Álvarez, Yolanda López, Alba Sierra‐Marcos, Rocio Trincado‐Lamuño, Mouna Ennazeh, Jesús González de la Aleja, Julia Renau, Maria Dolores Castro‐Vilanova, Fátima Romero‐Aguilera, José M. Serratosa   +29 more
wiley   +1 more source