Results 51 to 60 of about 411,780 (304)
Advanced Science, EarlyView.A programmable 3D Neuron‐Injury‐on‐a‐Chip platform integrates multiaxial mechanical loading with ultrasensitive electrochemical biosensing to decode neuronal responses in real time. By mimicking physiologically relevant extension–torsion forces, the system reveals load‐specific biomarker trajectories (T‐Tau, NFL), gene regulation, and apoptosis.
Sultan Khetani +12 more
wiley +1 more source
Advanced Science, EarlyView.Utilizing a mitochondrial double‐targeted strategy, a novel near‐infrared fluorescent probe (FTZ‐2) is established for monitoring viscosity variations in ferroptosis‐mediated drug‐induced liver injury. In summary, this work provided a practical strategy for the early diagnosis and evaluation of liver injury.
Yongqing Zhou +5 more
wiley +1 more source
Advanced Science, EarlyView.Histone 3 lysine18 lactylation (H3K18la) drives heterogeneous nuclear ribonucleoprotein C (HNRNPC) overexpression, activating autophagy to mediate gemcitabine resistance by stabilizing TNF receptor‐associated factor 6 (TRAF6) mRNA. Concurrently, HNRNPC stabilizes aldehyde dehydrogenase 1 family member A3 (ALDH1A3) mRNA, which enhances glycolysis and ...
Xi‐Tai Huang +9 more
wiley +1 more source
Infant health and longevity: Evidence from a historical trial in Sweden [PDF]
, 2015 This paper investigates the potential of an infant intervention to improve life expectancy, contributing to emerging interest in the early life origins of chronic disease.
Bhalotra, Sonia R. +2 more
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Advanced Science, EarlyView.This study harnesses hydrodynamic flows to generate, confine and stimulate stem cell spheroids, enabling the large‐scale production of extracellular vesicles (EVs). This innovative method not only streamlines spheroid formation and subsequent EV release in a single, integrated process, but also ensures the generation of EVs with enhanced biological ...
Solène Lenoir +7 more
wiley +1 more source
Red Blood Cell‐Derived Exosomal miR‐93‐5p Promotes Lung Cancer Progression through PTEN Suppression
Advanced Science, EarlyView.Red blood cell (RBC)‐derived exosomal miR‐93‐5p is elevated in lung cancer patients and correlates with poor outcomes. Exosomal miR‐93‐5p suppresses PTEN in cancer cells, enhancing proliferation, migration, and invasion. In mouse models, therapeutic inhibition with ASO‐miR‐93 5p reduces tumor growth, highlighting a bidirectional tumor‐RBC‐tumor axis ...
Ning Li +4 more
wiley +1 more source
Diabetes-related deaths in Australia, 2001–2003 [PDF]
Highlights This report presents information on diabetes-related deaths in Australia between 2001 and 2003 using death certificate data. The term ‘diabetes-related deaths’ is used in this analysis to refer to deaths where diabetes was considered to have ...
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Barnes Hospital Record Special Edition [PDF]
, 1950 https://digitalcommons.wustl.edu/bjc_barnes_record/1044/thumbnail ...
core +1 more source