Results 141 to 150 of about 1,987,954 (258)

Ecologic study of influenza vaccination uptake and COVID-19 death rate in New York City. [PDF]

BMC Public Health, 2022
Moreland A, Gillezeau C, Eugene A, Alpert N, Taioli E.   +4 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Reduction in finisher pig death rate on a farm in Japan following use of a commercial killed vaccine against porcine reproductive and respiratory syndrome virus. [PDF]

J Vet Med Sci
Yonezawa Y, Nakagami T, Tsutsumi N, Momma N, Taira O, Matsuyama R, Makita K.   +6 more
europepmc   +1 more source

The human life vs economic loss dilemma: Relation between death rate and the output rate in Europe during the Covid 19 pandemic. [PDF]

J Policy Model, 2023
Bollino CA.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Reduction in TB Death Rate in Dharmapuri, Karur, and Villupuram Following Tamil Nadu <i>Kasanoi Erappila Thittam</i> (TN-KET). [PDF]

Indian J Community Med
Rajkumar S, Saravanan R, Sudhakar R, Ravichandran P, Rajasekar TD, Pradeep SK, Balasubramaniam M, Umapathi S, Sagindar S, Pathinathan DP, Suma KV, Frederick A, Shewade HD.   +12 more
europepmc   +1 more source

COVID-19 Incidence and Death Rate in Epilepsy: Too Early to Tell? [PDF]

Epilepsy Curr, 2021
Vossler DG.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Impact of hydatid cyst laminated layer antigens on cell death rate, apoptosis induction, and key genes in the cell proliferation pathway: Insights from A549 cell line studies. [PDF]

PLoS One
Hosseini E, Tavakoli-Yaraki M, Meamar AR, Ajam Z, Alipour M, Bagga R, Razmjou E, Rafiei-Sefiddashti R.   +7 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source