Results 181 to 190 of about 4,160,890 (294)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Impact of hydatid cyst laminated layer antigens on cell death rate, apoptosis induction, and key genes in the cell proliferation pathway: Insights from A549 cell line studies. [PDF]

PLoS One
Hosseini E, Tavakoli-Yaraki M, Meamar AR, Ajam Z, Alipour M, Bagga R, Razmjou E, Rafiei-Sefiddashti R.   +7 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Age-adjusted death rate from and incidence of stroke and myocardial infarction over 24 years in O City, Ehime Prefecture, Japan: an observational cohort study. [PDF]

J Rural Med
Toda M, Maruyama K, Saito I, Tanaka S, Takeuchi Y, Okubo H, Kato T.   +6 more
europepmc   +1 more source

Investigation of Death Rate Due to Type 2 Traffic Accidents and Non-Traffic Accidents in Iran during 2013-2018. [PDF]

Iran J Public Health, 2022
Hasani J, Erfanpoor S, Nazari SSH.
europepmc   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

How to Reduce Maternal Death Rate [PDF]

, 1938
Catholic Physicians\u27 Guild
core   +1 more source

Functional genomic screens with death rate analyses reveal mechanisms of drug action. [PDF]

Nat Chem Biol
Honeywell ME, Isidor MS, Harper NW, Fontana RE, Birdsall GA, Cruz-Gordillo P, Porto SA, Jerome M, Fraser CS, Sarosiek KA, Guertin DA, Spinelli JB, Lee MJ.   +12 more
europepmc   +1 more source

Nationwide analysis of COVID-19 death rate throughout the pandemic in Italy

, 2022
Mattiuzzi C, Lippi G.
europepmc   +1 more source

A GABA-receptor agonist reduces pneumonitis severity, viral load, and death rate in SARS-CoV-2-infected mice. [PDF]

Front Immunol, 2022
Tian J, Dillion BJ, Henley J, Comai L, Kaufman DL.   +4 more
europepmc   +1 more source