Results 101 to 110 of about 3,017,544 (276)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Image Similarity Metrics in Image Registration [PDF]

open access: yes, 2010
Measures of image similarity that inspect the intensity probability distribution of the images have proved extremely popular in image registration applications. The joint entropy of the intensity distributions and the marginal entropies of the individual
Melbourne, A, Ridgway, G, Hawkes, DJ
core  

Plane-based Coarse Registration of 3D Point Clouds with 4D Models [PDF]

open access: yes, 2011
The accurate registration of 3D point clouds with project 3D/4D models is becoming more and more important with the development of BIM and 3D laser scanning, for which the registration in a common coordinate system is critical to project control.
Bosché, Frédéric, Frederic Bosche
core   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

The death of good faith in registration

open access: yesThēmis, 2015
The article 2014 of the Civil Code has been recently modified.  In  order  to  make this decision, the legislator took in consideration two reasons: theaffirmation that the record entry doesn’t countswith its own substantivity, and that the necessityof ...
Freddy Escobar Rozas
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

DEATH CERTIFICATION AND REGISTRATION. [PDF]

open access: yesThe Lancet, 1899
IN the first place, I have to thank you done me in electing me your President to ask you to accept my assurance that to further the interest of this Society. usual custom, it i~ my duty to deliver a for the honour you have for the ensuing year, and I will do all in my power In accordance with the short address on this our first meeting.
openaire   +2 more sources

Mortality and cause-of-death reporting and analysis systems in seven pacific island countries

open access: yesBMC Public Health, 2012
Background Mortality statistics are essential for population health assessment. Despite limitations in data availability, Pacific Island Countries are considered to be in epidemiological transition, with non-communicable diseases increasingly ...
Carter Karen L   +3 more
doaj   +1 more source

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