Results 261 to 270 of about 1,047,819 (346)

Microglia Mitochondria Support Neuronal Maturation via Metabolic and Transcriptional Reprogramming in Human 3D In Vitro Brain Model

Advanced Science, EarlyView.
xx xx. ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contributors to ASD‐associated biology, yet the mechanisms linking these processes to neuronal development remain poorly defined ...
Sydney P. Sterben, Charitha C. Anamala, Sahan B. S. Kansakar, Vaishnavi Koduri, Volha Liaudanskaya   +4 more
wiley   +1 more source

AXL Promotes Ischemic Myelin Repair Through Alleviating Myelin Debris Deposition and Lipid Droplets Accumulation. [PDF]

Adv Sci (Weinh)
Jia J, Gan Y, Li J, Li L, Meng H, Sun M, Ye L, Mao R, Cao X, Xia S, Bao X, Liu R, Zhang M, Xu Y.   +13 more
europepmc   +1 more source

Protein Language Model‐Guided Engineering of a 2,3‐Butanediol Dehydrogenase for the Enantioselective Synthesis of Cyclic α‐Hydroxy Ketones

Advanced Science, EarlyView.
A (2R,3R)‐butanediol dehydrogenase from Bacillus subtilis (BsBDH) is engineered for the enantioselective synthesis of 2‐hydroxycyclohexanone. A PASS computational design strategy is proposed to enhance the thermostability of BsBDH. Moreover, ESM‐1v combined with ISM is utilized for enhancing and inverting its stereoselectivity.
Haote Ding, Ling Jiang, Yijia Song, Zhongji Pu, Lirong Yang, Haoran Yu   +5 more
wiley   +1 more source

Cytological Clues to Pharyngoesophageal Diverticula Mimicking Thyroid Nodules. [PDF]

Diagn Cytopathol
Lin YW, Kao TH, Lee TL, Hang JF.
europepmc   +1 more source

Utilizing Various Geospatial Data for Debris Flow Geological Hazard Characterization and Mapping at Jerai Geopark, Malaysia

Mohamad Rashidi Md.Razli, Mohamad Faruq Syahmi Md Aripin, Muhammad Afiq Ariff Mohd Hellmy, Muhammad Faris Qusyairi Hamat, Zakaria Mohamad, Abd Rasid Jaapar, Awais Ali, Mohamed Syahrizal Zakaria   +7 more
openalex   +1 more source

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

Reuse of single-use Kahook dual blade: Safety and ethics. [PDF]

Indian J Ophthalmol
Mansoori T.
europepmc   +1 more source

Measuring the Transport of Floating Plastic Debris Using Vessel-Based Optical Data and Artificial Intelligence

Mattia Romero, Yannick Pham, Laura Gómez‐Navarro, Robin de Vries, Bruno Sainte-Rose   +4 more
openalex   +1 more source

Biodegradable Carbonate Nanogels Loaded with Anti MFAP‐5 siRNA for Anti‐stromal Therapy of Hepatocellular Carcinoma

Advanced Science, EarlyView.
Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider, Alexander Fuchs, Michael Fichter, Vanessa Bolduan, Jenny Schunke, Özlem Akilli, Nádia C. Correia, Yannick Ehlers, Christian Czysch, Pia Winterwerber, Eliana Stanganello, Barbara Schrörs, Mustafa Diken, Christoph Eckert, Shusruto Rishik, Andreas Keller, Jörn M. Schattenberg, Stephan Grabbe, Matthias Bros, Lutz Nuhn, Leonard Kaps   +20 more
wiley   +1 more source

Deep learning enabled rapid detection of live bacteria in the presence of food debris. [PDF]

NPJ Sci Food
Park HW, Li Z, Ma L, Nitin N.
europepmc   +1 more source