Results 41 to 50 of about 575,458 (256)

An axiomatic system engineering design method based on NSGA-II algorithm applied to complex systems

Scientific Reports
This study proposes an integrated framework that combines Axiomatic Design with Model-Based Systems Engineering, incorporating NSGA-II as an intelligent optimization engine. The framework constructs a multi-level traceability matrix linking requirements,
Xiaoqian Zhang, Qinghai Zhang, Qingjian Zhao, Shuang Zhao, Yanan Zhao, Yang Guo, Zhengxu Zhao, Liqiang Song   +7 more
doaj   +1 more source

Remotely sensed debris thickness mapping of Bara Shigri Glacier, Indian Himalaya [PDF]

, 2015
Despite the important role of supraglacial debris in ablation, knowledge of debris thickness on Himalayan glaciers is sparse. A recently developed method based on reanalysis data and thermal band satellite imagery has proved to be potentially suitable ...
Kulkarni, Anil, Schauwecker, Simone, Rohrer, Mario, Ramanathan, Al, Huggel, Christian, Kulkarni, Anil V, Stoffel, Markus, Schauwecker, Simone Marianna, Ramanathan, A L, Rohrer, Mario Bruno, Ramanathan, Al., Brock, Ben, Brock, Benjamin, Salzmann, Nadine   +13 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

An ecosystem-scale litter and microplastics monitoring plan under the Arctic Monitoring and Assessment Programme (AMAP)

Arctic Science, 2022
Lack of knowledge on levels and trends of litter and microplastics in the Arctic, is limiting our understanding of the sources, transport, fate, and effects is hampering global activities aimed at reducing litter and microplastics in the environment.
Jennifer Provencher, Tanja Kögel, Amy Lusher, Katrin Vorkamp, Alessio Gomiero, Ilka Peeken, Maria Granberg, Sjúrður Hammer, Julia Baak, Jan Rene Larsen, Eivind Farmen   +10 more
doaj   +1 more source

A comparison of glacier melt on debris-covered glaciers in the northern and southern Caucasus [PDF]

, 2011
The glacier coverage in the Caucasus Mountains underwent considerable changes during the last decades. In some regions, the observed reduction in glacier area is comparable to those in the European Alps and the extent of supra-glacial debris increased on
W. Hagg, A. Lambrecht, Popovnin, V., Lambrecht, A., A. Rezepkin, Hagg, Wilfried, Svanadze, D., C. Mayer, Rezepkin, A., N. Lomidze, D. Svanadze, Lomidze, N., V. Popovnin, Mayer, C.   +13 more
core   +2 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Engineering-geological study of debris slide-debris flow triggering mechanism in the peri-vesuvian area [PDF]

, 2009
Nella tesi dal titolo “Engineering-geological study of debris slide-debris flow triggering mechanism in the peri-vesuvian area” il dottorando ha affrontato la complessa problematica dell’instabilità delle coltri piroclastiche che rappresenta una delle ...
Rolandi, Massimiliano
core   +1 more source

Cost estimate for clean up and debris removal

, 2020
Title from PDF caption (viewed on March 3, 2022)."The Labor Day Fires constitute the biggest and most expensive disaster in Oregon history. The current total cost estimate for debris clean up is $622 million (hazard tress and ash and debris on private ...

core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Rise velocity of small polyolefin plastics in a seawater tank exposed to natural conditions in Hawai’i

Environmental Research Communications
Floating plastic is ubiquitous at the ocean surface, but the transport mechanisms associated with the type of particle and the effect of environmental parameters, including the presence of a biofilm on the polymers, are very limited.
Sarah-Jeanne Royer, Kayla C Brignac, Ferenc Ronkay, Kellie Teague, Granya Morris, Jennifer Lynch, Laurent Lebreton   +6 more
doaj   +1 more source