Results 41 to 50 of about 995,709 (250)
FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
Numerical Simulation of Non-Homogeneous Viscous Debris-Flows Based on the Smoothed Particle Hydrodynamics (SPH) Method [PDF]
, 2019 Non-homogeneous viscous debris flows are characterized by high density, impact force and destructiveness, and the complexity of the materials they are made of.
Anping Shu +12 more
core +2 more sources
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
RRS Charles Darwin Cruise 126, 11 Mar-20 Mar 2001. Piston coring of debris flows and turbidites west and south of the Canary Islands [PDF]
, 2002 The major cruise objective was to obtain sediment cores at various locations to the west and southwest of the Canary Islands with the aims of :· Sampling debris flow sediments in the Canary and Saharan debris flows· Obtaining dateable sediments ...
Masson, D.G.
core
Feasibility of transit photometry of nearby debris discs [PDF]
, 2014 Dust in debris discs is constantly replenished by collisions between larger objects. In this paper, we investigate a method to detect these collisions.
Kalas, P. +2 more
core +3 more sources
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Propagation and deposition of stony debris flows at channel confluences [PDF]
, 2015 The fluid dynamics of stony debris flows generated in two small tributaries adjacent to each other and flowing into a main receiving channel was analyzed experimentally at a laboratory scale.
Foti, E. +2 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu +10 more
wiley +1 more source
CoSMO, 2023 Thinking about modernist urbanism as a period in architecture with potential for the future of cities has been outside the canon for several decades. But from a critical viewpoint, the postmodern stance on modernist mass housing continuously failed to dissociate high modernist urbanism as a unified architectural project from its socio-political ...
openaire +2 more sources